<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Biological factors that characterize extrinsic plaque vulnerability include various pro- and anti-inflammatory cytokines that contribute to the development and progression of atherosclerosis. Adhesion molecules are among the initiators of the atherosclerotic process, by mediation of endothelial inflammation. The soluble forms of these adhesion molecules have been identified in the circulatory blood, with an increased level in case of subjects with atherosclerotic lesions and higher levels in patients with acute coronary syndromes or vulnerable plaques. In addition, several authors have found a significant predictive capacity of these molecules in case of patients presenting with acute coronary and cerebrovascular events. The aim of this manuscript is to provide a short description of the role of adhesion molecules in the development and progression of atherosclerotic lesions towards acute coronary syndromes, as well as their capacity for predicting major adverse cardiovascular events in vulnerable cardiovascular patients.</p>
</abstract>

Biological factors that characterize extrinsic plaque vulnerability include various pro- and anti-inflammatory cytokines that contribute to the development and progression of atherosclerosis. Adhesion molecules are among the initiators of the atherosclerotic process, by mediation of endothelial inflammation. The soluble forms of these adhesion molecules have been identified in the circulatory blood, with an increased level in case of subjects with atherosclerotic lesions and higher levels in patients with acute coronary syndromes or vulnerable plaques. In addition, several authors have found a significant predictive capacity of these molecules in case of patients presenting with acute coronary and cerebrovascular events. The aim of this manuscript is to provide a short description of the role of adhesion molecules in the development and progression of atherosclerotic lesions towards acute coronary syndromes, as well as their capacity for predicting major adverse cardiovascular events in vulnerable cardiovascular patients.

Adhesion Molecules and Vulnerable Plaques – Promoters of Acute Coronary Syndromes

“George Emil Palade” University of Medicine

Journal of Cardiovascular Emergencies

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Biological factors that characterize extrinsic plaque vulnerability include various pro- and anti-inflammatory cytokines that contribute to the development and...

Adhesion Molecules and Vulnerable Plaques – Promoters of Acute Coronary Syndromes

Publié en ligne: 27 janv. 2023

Pages: 59 - 63

Reçu: 17 juil. 2022

Accepté: 01 août 2022

DOI: https://doi.org/10.2478/jce-2022-0009

Mots clés
adhesion molecules, endothelial inflammation, vulnerable plaques, major adverse cardiovascular events

© 2022 Diana Opincariu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Adhesion Molecules and Vulnerable Plaques – Promoters of Acute Coronary Syndromes

Publié en ligne: 27 janv. 2023

Pages: 59 - 63

Reçu: 17 juil. 2022

Accepté: 01 août 2022

DOI: https://doi.org/10.2478/jce-2022-0009

Mots clésadhesion molecules, endothelial inflammation, vulnerable plaques, major adverse cardiovascular events

© 2022 Diana Opincariu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
adhesion molecules, endothelial inflammation, vulnerable plaques, major adverse cardiovascular events