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The Use of Diuretic in Mechanically Ventilated Children with Viral Bronchiolitis: A Cohort Study

Nisha Agasthya
Nisha Agasthya
, 
Kimberlee Chromey
Kimberlee Chromey
, 
James H. Hertzog
James H. Hertzog
 et 
Jigar C. Chauhan
Jigar C. Chauhan
   | 12 mai 2021
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Article Category: Research Article
Publié en ligne: 12 mai 2021
Pages: 97 - 103
Reçu: 28 nov. 2020
Accepté: 31 janv. 2021
DOI: https://doi.org/10.2478/jccm-2021-0008
Mots clés
© 2021 Nisha Agasthya, Kimberlee Chromey, James H. Hertzog, Jigar C. Chauhan, published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Fig. 1

Correlation plot of percent fluid overload after 24 hours of mechanical ventilation (FO1) and duration of mechanical ventilation
Correlation plot of percent fluid overload after 24 hours of mechanical ventilation (FO1) and duration of mechanical ventilation

Fig. 2

Box plot showing comparison of percent fluid overload after 24 hours of mechanical ventilation (FO1) and pneumonia status in patients
Box plot showing comparison of percent fluid overload after 24 hours of mechanical ventilation (FO1) and pneumonia status in patients

Pre and post 24 hour clinical and laboratory variables among patients who received intravenous furosemide

N = 179 Pre diuretic Post diuretic p-value
CFB in ml [median IQR] 891 [588.50-1263] 807 [565-1368] 0.47
FO per cent [median IQR] 14 [9.30-19.02] 13.87 [10.55-19.06] 0.59
Weight in kg [median IQR] 6.10 [4.4-9.20] 6.55 [4.4-9.40] 0.73
FiO2 [median IQR] 0.45 [0.3-0.45] 0.35 [0.3-0.4] 0.007
PEEP [median IQR] 7 [5-8] 6 [5-8] 0.47
SpO2:FiO2 [median IQR] 270 [214-321] 280 [242-330] 0.034
Serum creatinine [median IQR] 0.2 [0.2-0.3] 0.2 [0.2-0.3] 1.0
Serum blood urea nitrogen [median IQR] 5 [2-7] 5 [3-9] 1.0
Serum bicarbonate [median IQR] 26 [23-29] 32 [28-36] < 0.001

Viral and bacterial isolate profile

Virus, n = 224 (%)
RSV 65
Non-RSV 25
2 non-RSV 7
3 or more 3

Demographic and epidemiologic characteristics of the two cohort groups

Group N Group F p-value
Sample size (n) 224 45 179
Males (%) 27 (60) 106 (59.2) 1.0
Age in months [median IQR] 5 [2-12] 4 [2-9] 0.42
PICU LOS in days [median IQR] 6 [4-8] 10 [7-13] < 0.001
#HD MV [median IQR] 1 [1] 1 [1-2] 1
Duration of MV [median IQR] 4 [3-5] 6 [5-9] < 0.001
Admission weight in kg [median IQR] 7.7 [4-10] 6.2 [4.2-9.15] 0.48
Discharge weight in kg [median IQR] 7.6 [4-10] 6.10 [4.4-9.2] 0.58
CFB1 in ml [median IQR] 376 [200-700] 573 [298.50-797.25] 0.03
FO1 [median IQR] 6.16 [3.12-8.24] 9.03 [5.29-12.87] 0.003
Initial FiO2 [median IQR] 0.40 [0.35-0.50] 0.45 [0.40-0.55] 0.014
Initial PEEP [median IQR] 5 [5-8] 7 [5-8] 0.195
PRISM IV [median IQR] 1 [1-2] 1 [1-2] 1.0
Bronchodilator (%) 23 (51.1) 123 (68.7) 0.04
Corticosteroids (%) 12 (26.7) 82 (45.8) 0.03
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Langue:
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Medicine, Clinical Medicine, Internal Medicine, other, Surgery, Anaesthesiology, Emergency Medicine and Intensive-Care Medicine
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