This work is licensed under the Creative Commons Attribution 4.0 International License.
Rich S, Haworth SG, Hassoun PM, Yacoub MH. Pulmonary hypertension: The unaddressed global health burden. Lancet Respir Med. 2018;6:577–9.RichSHaworthSGHassounPMYacoubMHPulmonary hypertension: The unaddressed global health burdenLancet Respir Med20186577910.1016/S2213-2600(18)30268-6Search in Google Scholar
Simonneau G, Montani D, Celermajer DS, Denton CP, Gatzoulis MA, Krowka M, et al. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J. 2019;53:1801913.SimonneauGMontaniDCelermajerDSDentonCPGatzoulisMAKrowkaMet alHaemodynamic definitions and updated clinical classification of pulmonary hypertensionEur Respir J201953180191310.1183/13993003.01913-2018635133630545968Search in Google Scholar
Frost AE, Badesch DB, Barst RJ, Benza RL, Elliott CG, Farber HW, et al. The Changing Picture of Patients With Pulmonary Arterial Hypertension in the United States. Chest. 2011;139:128–37.FrostAEBadeschDBBarstRJBenzaRLElliottCGFarberHWet alThe Changing Picture of Patients With Pulmonary Arterial Hypertension in the United StatesChest20111391283710.1378/chest.10-007520558556Search in Google Scholar
Ling Y, Johnson MK, Kiely DG, Condliffe R, Elliot CA, Gibbs JSR, et al. Changing Demographics, Epidemiology and Survival of Incident Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2012;186:790–6.LingYJohnsonMKKielyDGCondliffeRElliotCAGibbsJSRet alChanging Demographics, Epidemiology and Survival of Incident Pulmonary Arterial HypertensionAm J Respir Crit Care Med2012186790610.1164/rccm.201203-0383OC22798320Search in Google Scholar
Lau EMT, Giannoulatou E, Celermajer DS, Humbert M. Epidemiology and treatment of pulmonary arterial hypertension. Nat Rev Cardiol. 2017;14:603–14.LauEMTGiannoulatouECelermajerDSHumbertMEpidemiology and treatment of pulmonary arterial hypertensionNat Rev Cardiol2017146031410.1038/nrcardio.2017.8428593996Search in Google Scholar
Hiraide T, Kataoka M, Suzuki H, Aimi Y, Chiba T, Isobe S, et al. Poor outcomes in carriers of the RNF213 variant (p.Arg4810Lys) with pulmonary arterial hypertension. J Hear Lung Transplant. 2020;39:103–12.HiraideTKataokaMSuzukiHAimiYChibaTIsobeSet alPoor outcomes in carriers of the RNF213 variant (p.Arg4810Lys) with pulmonary arterial hypertensionJ Hear Lung Transplant2020391031210.1016/j.healun.2019.08.02231542298Search in Google Scholar
Hoeper MM, Galié N, Murali S, Olschewski H, Rubenfire M, Robbins IM, et al. Outcome after cardiopulmonary resuscitation in patients with pulmonary arterial hypertension. Am J Respir Crit Care Med. 2002;165:341–4.HoeperMMGaliéNMuraliSOlschewskiHRubenfireMRobbinsIMet alOutcome after cardiopulmonary resuscitation in patients with pulmonary arterial hypertensionAm J Respir Crit Care Med2002165341410.1164/ajrccm.165.3.200109-0130c11818318Search in Google Scholar
Galiè N, Humbert M, Vachiery J-L, Gibbs S, Lang I, Torbicki A, et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J. 2015;46:903–75.GalièNHumbertMVachieryJ-LGibbsSLangITorbickiAet al2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertensionEur Respir J2015469037510.1183/13993003.01032-201526318161Search in Google Scholar
Naeije R, Chin K. Differentiating Precapillary From Postcapillary Pulmonary Hypertension. Circulation. 2019;140:712–4.NaeijeRChinKDifferentiating Precapillary From Postcapillary Pulmonary HypertensionCirculation2019140712410.1161/CIRCULATIONAHA.119.04029531449453Search in Google Scholar
Lai YC, Potoka KC, Champion HC, Mora AL, Gladwin MT. Pulmonary arterial hypertension: The clinical syndrome. Circ Res. 2014;115:115–30.LaiYCPotokaKCChampionHCMoraALGladwinMTPulmonary arterial hypertension: The clinical syndromeCirc Res20141151153010.1161/CIRCRESAHA.115.301146409668624951762Search in Google Scholar
Ghigna M-R, Dorfmüller P. Pulmonary vascular disease and pulmonary hypertension. Diagnostic Histopathol. 2019;25:304– 12.GhignaM-RDorfmüllerPPulmonary vascular disease and pulmonary hypertensionDiagnostic Histopathol201925:304–1210.1016/j.mpdhp.2019.05.002Search in Google Scholar
S. A-OM, Stuart S, Boyle AJ, Sverdlov AL, Collins NJ. Pulmonary Hypertension Due to Left Heart Disease. Hypertension. 2020;75:1397–408.A-OMS.StuartSBoyleAJSverdlovALCollinsNJPulmonary Hypertension Due to Left Heart DiseaseHypertension202075139740810.1161/HYPERTENSIONAHA.119.1433032336230Search in Google Scholar
Fishman AP, McClement J, Himmelstein A, Cournand A. Effects of acute anoxia on the circulation and respiration in patients with chronic pulmonary disease studied during the steady state. J Clin Invest. 1952;31:770–81.FishmanAPMcClementJHimmelsteinACournandAEffects of acute anoxia on the circulation and respiration in patients with chronic pulmonary disease studied during the steady stateJ Clin Invest1952317708110.1172/JCI10266243647314955529Search in Google Scholar
Peinado VI, Barberà JA, Abate P, Ramírez J, Roca J, Santos S, et al. Inflammatory reaction in pulmonary muscular arteries of patients with mild chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999;159:1605–11.PeinadoVIBarberàJAAbatePRamírezJRocaJSantosSet alInflammatory reaction in pulmonary muscular arteries of patients with mild chronic obstructive pulmonary diseaseAm J Respir Crit Care Med199915916051110.1164/ajrccm.159.5.980705910228134Search in Google Scholar
Moser KM, Bloor CM. Pulmonary vascular lesions occurring in patients with chronic major vessel thromboembolic pulmonary hypertension. Chest. 1993;1:685–92.MoserKMBloorCMPulmonary vascular lesions occurring in patients with chronic major vessel thromboembolic pulmonary hypertensionChest199316859210.1378/chest.103.3.6858449052Search in Google Scholar
Crystal GJ, Pagel PS. Right Ventricular Perfusion: Physiology and Clinical Implications. Anesthesiology. 2018;128:202–18.CrystalGJPagelPSRight Ventricular Perfusion: Physiology and Clinical ImplicationsAnesthesiology20181282021810.1097/ALN.000000000000189128984631Search in Google Scholar
Zong P, Tune JD, Downey HF. Mechanisms of oxygen demand/supply balance in the right ventricle. Exp Biol Med. 2005;280:507–19.ZongPTuneJDDowneyHFMechanisms of oxygen demand/supply balance in the right ventricleExp Biol Med20052805071910.1177/15353702052300080116118400Search in Google Scholar
Hart BJ, Bian X, Gwirtz PA, Setty S, Downey HF. Right ventricular oxygen supply/demand balance in exercising dogs. Am J Physiol - Hear Circ Physiol. 2001;281:H823-30.HartBJBianXGwirtzPASettySDowneyHFRight ventricular oxygen supply/demand balance in exercising dogsAm J Physiol - Hear Circ Physiol2001281H8233010.1152/ajpheart.2001.281.2.H82311454587Search in Google Scholar
Guarracino F, Cariello C, Danella A, Doroni L, Lapolla F, Vullo C, Pasquini C, Stefani M. Right ventricular failure: physiology and assessment. Minerva Anestesiol. 2005;71:307–12.GuarracinoFCarielloCDanellaADoroniLLapollaFVulloCPasquiniCStefaniMRight ventricular failure: physiology and assessmentMinerva Anestesiol20057130712Search in Google Scholar
Yonekura S, Watanabe N, Downey HF. Transmural variation in autoregulation of right ventricular blood flow. Circ Res. 1988;62:776–81.YonekuraSWatanabeNDowneyHFTransmural variation in autoregulation of right ventricular blood flowCirc Res1988627768110.1161/01.RES.62.4.776Search in Google Scholar
Rosenkranz S, Gibbs JSR, Wachter R, De Marco T, Vonk-Noordegraaf A, Vachiéry J-L. Left ventricular heart failure and pulmonary hypertension. Eur Heart J. 2016;37:942–54.RosenkranzSGibbsJSRWachterRDe MarcoTVonk-NoordegraafAVachiéryJ-LLeft ventricular heart failure and pulmonary hypertensionEur Heart J2016379425410.1093/eurheartj/ehv512480017326508169Search in Google Scholar
Haddad F, Couture P, Tousignant C, Denault AY. The right ventricle in cardiac surgery, a perioperative perspective: I. anatomy, physiology, and assessment. Anesth Analg. 2009;108:422–33.HaddadFCouturePTousignantCDenaultAYThe right ventricle in cardiac surgery, a perioperative perspective: Ianatomy, physiology, and assessment. Anesth Analg20091084223310.1213/ane.0b013e31818d8b92Search in Google Scholar
Baumgart D, Haude M, Görge G, Liu F, Ge J, Große-Eggebrecht C, et al. Augmented α-adrenergic constriction of atherosclerotic human coronary arteries. Circulation. 1999;99:2090–7.BaumgartDHaudeMGörgeGLiuFGeJGroße-EggebrechtCet alAugmented α-adrenergic constriction of atherosclerotic human coronary arteriesCirculation1999992090710.1161/01.CIR.99.16.2090Search in Google Scholar
Murphree SS, Saffitz JE. Delineation of the distribution of β-adrenergic receptor subtypes in canine myocardium. Circ Res. 1988;63:117–25.MurphreeSSSaffitzJEDelineation of the distribution of β-adrenergic receptor subtypes in canine myocardiumCirc Res1988631172510.1161/01.RES.63.1.117Search in Google Scholar
Crystal GJ, Zhou X, Alam S, Piotrowski A, Hu G. Lack of role for nitric oxide in cholinergic modulation of myocardial contractility in vivo. Am J Physiol - Hear Circ Physiol. 2001;281:H198-206.CrystalGJZhouXAlamSPiotrowskiAHuGLack of role for nitric oxide in cholinergic modulation of myocardial contractility in vivoAm J Physiol - Hear Circ Physiol2001281H19820610.1152/ajpheart.2001.281.1.H198Search in Google Scholar
Runo JR, Loyd JE. Primary pulmonary hypertension. Lancet. 2003;361:1533–44.RunoJRLoydJEPrimary pulmonary hypertensionLancet200336115334410.1016/S0140-6736(03)13167-4Search in Google Scholar
Le RJ, Fenstad ER, Maradit-Kremers H, McCully RB, Frantz RP, McGoon MD, et al. Syncope in adults with pulmonary arterial hypertension. J Am Coll Cardiol. 2011;58:863–7.LeRJFenstadERMaradit-KremersHMcCullyRBFrantzRPMcGoonMDet alSyncope in adults with pulmonary arterial hypertensionJ Am Coll Cardiol201158863710.1016/j.jacc.2011.04.02621835323Search in Google Scholar
Mandras SA, Mehta HS, Vaidya A. Pulmonary Hypertension: A Brief Guide for Clinicians. Mayo Clin Proc. 2020;95:1978–88.MandrasSAMehtaHSVaidyaAPulmonary Hypertension: A Brief Guide for CliniciansMayo Clin Proc20209519788810.1016/j.mayocp.2020.04.03932861339Search in Google Scholar
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, et al. 2015 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension: The joint task force for the diagnosis and treatment of pulmonary hypertension of the european society of cardiology (ESC) and the european respiratory society (ERS): Endor. Eur Heart J. 2016;37:67–119.GalièNHumbertMVachieryJLGibbsSLangITorbickiAet al2015 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension: The joint task force for the diagnosis and treatment of pulmonary hypertension of the european society of cardiology (ESC) and the european respiratory society (ERS): EndorEur Heart J2016376711910.1093/eurheartj/ehv31726320113Search in Google Scholar
Altschul E, Remy-Jardin M, Machnicki S, Sulica R, Moore JA, Singh A, et al. Imaging of Pulmonary Hypertension: Pictorial Essay. Chest. 2019;156:211–27.AltschulERemy-JardinMMachnickiSSulicaRMooreJASinghAet alImaging of Pulmonary Hypertension: Pictorial EssayChest20191562112710.1016/j.chest.2019.04.00330981724Search in Google Scholar
Augustine DX, Coates-Bradshaw LD, Willis J, Harkness A, Ring L, Grapsa J, et al. Echocardiographic assessment of pulmonary hypertension: A guideline protocol from the British Society of Echocardiography. Echo Res Pract. 2018;5:11–24.AugustineDXCoates-BradshawLDWillisJHarknessARingLGrapsaJet alEchocardiographic assessment of pulmonary hypertension: A guideline protocol from the British Society of EchocardiographyEcho Res Pract20185112410.1530/ERP-17-0071605550930012832Search in Google Scholar
Ristow B, Ahmed S, Wang L, Liu H, Angeja BG, Whooley MA, et al. Pulmonary regurgitation end-diastolic gradient is a doppler marker of cardiac status: Data from the heart and soul study. J Am Soc Echocardiogr. 2005;18:885–91.RistowBAhmedSWangLLiuHAngejaBGWhooleyMAet alPulmonary regurgitation end-diastolic gradient is a doppler marker of cardiac status: Data from the heart and soul studyJ Am Soc Echocardiogr2005188859110.1016/j.echo.2005.06.004Search in Google Scholar
Kyranis S, Latona J, Savage M, Kelly N, Burstow D, Scalia G, et al. Tricuspid Regurgitation Velocity in the Assessment of Pulmonary Hypertension: Is it Accurate at All? Hear Lung Circ. 2016;25:257.KyranisSLatonaJSavageMKellyNBurstowDScaliaGet alTricuspid Regurgitation Velocity in the Assessment of Pulmonary Hypertension: Is it Accurate at All?Hear Lung Circ20162525710.1016/j.hlc.2016.06.597Search in Google Scholar
Sun XG, Hansen JE, Oudiz RJ, Wasserman K. Pulmonary function in primary pulmonary hypertension. J Am Coll Cardiol. 2003;41:1028–35.SunXGHansenJEOudizRJWassermanKPulmonary function in primary pulmonary hypertensionJ Am Coll Cardiol20034110283510.1016/S0735-1097(02)02964-9Search in Google Scholar
Rich S, Dantzker DR, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, et al. Primary pulmonary hypertension. A national prospective study. Ann Intern Med. 1987;107:216–23.RichSDantzkerDRAyresSMBergofskyEHBrundageBHDetreKMet alPrimary pulmonary hypertensionA national prospective study. Ann Intern Med19871072162310.7326/0003-4819-107-2-216Search in Google Scholar
Low AT, Medford ARL, Millar AB, Tulloh RMR. Lung function in pulmonary hypertension. Respir Med. 2015;109:1244–9.LowATMedfordARLMillarABTullohRMRLung function in pulmonary hypertensionRespir Med20151091244910.1016/j.rmed.2015.05.022Search in Google Scholar
Hosenpud JD, Stibolt TA, Atwal K, Shelley D. Abnormal pulmonary function specifically related to congestive heart failure: Comparison of patients before and after cardiac transplantation. Am J Med. 1990;88:493–6.HosenpudJDStiboltTAAtwalKShelleyDAbnormal pulmonary function specifically related to congestive heart failure: Comparison of patients before and after cardiac transplantationAm J Med199088493610.1016/0002-9343(90)90428-GSearch in Google Scholar
Steenhuis LH, Groen HJM, Koeter GH, Van der Mark TW. Diffusion capacity and haemodynamics in primary and chronic thromboembolic pulmonary hypertension. Eur Respir J. 2000;16:276–81.SteenhuisLHGroenHJMKoeterGHVander Mark TWDiffusion capacity and haemodynamics in primary and chronic thromboembolic pulmonary hypertensionEur Respir J2000162768110.1034/j.1399-3003.2000.16b15.x10968503Search in Google Scholar
Levett DZH, Jack S, Swart M, Carlisle J, Wilson J, Snowden C, et al. Perioperative cardiopulmonary exercise testing (CPET): consensus clinical guidelines on indications, organization, conduct, and physiological interpretation. Br J Anaesth. 2018;120:484–500.LevettDZHJackSSwartMCarlisleJWilsonJSnowdenCet alPerioperative cardiopulmonary exercise testing (CPET): consensus clinical guidelines on indications, organization, conduct, and physiological interpretationBr J Anaesth201812048450010.1016/j.bja.2017.10.02029452805Search in Google Scholar
Farina S, Correale M, Bruno N, Paolillo S, Salvioni E, Badagliacca R, et al. The role of cardiopulmonary exercise tests in pulmonary arterial hypertension. Eur Respir Rev. 2018;27:170134.FarinaSCorrealeMBrunoNPaolilloSSalvioniEBadagliaccaRet alThe role of cardiopulmonary exercise tests in pulmonary arterial hypertensionEur Respir Rev20182717013410.1183/16000617.0134-201729720508Search in Google Scholar
Robertson HT. Dead space: The physiology of wasted ventilation. Eur Respir J. 2015;45:1704–16.RobertsonHTDead space: The physiology of wasted ventilationEur Respir J20154517041610.1183/09031936.0013761425395032Search in Google Scholar
Rosenkranz S, Preston IR. Right heart catheterisation: best practice and pitfalls in pulmonary hypertension. Eur Respir Rev. 2015;24:642– 52.RosenkranzSPrestonIRRight heart catheterisation: best practice and pitfalls in pulmonary hypertensionEur Respir Rev201524642–5210.1183/16000617.0062-2015Search in Google Scholar
Chatterjee NA, Lewis GD. What is the prognostic significance of pulmonary hypertension in heart failure? Circ Heart Fail. 2011;4:541–5.ChatterjeeNALewisGDWhat is the prognostic significance of pulmonary hypertension in heart failure?Circ Heart Fail20114541510.1161/CIRCHEARTFAILURE.111.963785Search in Google Scholar
Shanmugam E, Jena A, George M. Riociguat: Something new in pulmonary hypertension therapeutics? J Pharmacol Pharmacother. 2015;6:3–6.ShanmugamEJenaAGeorgeMRiociguat: Something new in pulmonary hypertension therapeutics?J Pharmacol Pharmacother201563610.4103/0976-500X.149132Search in Google Scholar
Desai A, Desouza SA. Treatment of pulmonary hypertension with left heart disease: A concise review. Vasc Health Risk Manag. 2017;13:415–20.DesaiADesouzaSATreatment of pulmonary hypertension with left heart disease: A concise reviewVasc Health Risk Manag2017134152010.2147/VHRM.S111597Search in Google Scholar
Kim NH, Delcroix M, Jais X, Madani MM, Matsubara H, Mayer E, et al. Chronic thromboembolic pulmonary hypertension. Eur Respir J. 2019;53:1801915KimNHDelcroixMJaisXMadaniMMMatsubaraHMayerEet alChronic thromboembolic pulmonary hypertensionEur Respir J201953180191510.1183/13993003.01915-2018Search in Google Scholar
Lang I, Meyer BC, Ogo T, Matsubara H, Kurzyna M, Ghofrani HA, et al. Balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension. Eur Respir Rev. 2017;26:160119.LangIMeyerBCOgoTMatsubaraHKurzynaMGhofraniHAet alBalloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertensionEur Respir Rev20172616011910.1183/16000617.0119-2016Search in Google Scholar
Simonneau G, D’Armini AM, Ghofrani HA, Grimminger F, Jansa P, Kim NH, et al. Predictors of long-term outcomes in patients treated with riociguat for chronic thromboembolic pulmonary hypertension: Data from the CHEST-2 open-label, randomised, long-term extension trial. Lancet Respir Med. 2016;4:372–80.SimonneauGD’ArminiAMGhofraniHAGrimmingerFJansaPKimNHet alPredictors of long-term outcomes in patients treated with riociguat for chronic thromboembolic pulmonary hypertension: Data from the CHEST-2 open-label, randomised, long-term extension trialLancet Respir Med201643728010.1016/S2213-2600(16)30022-4Search in Google Scholar
Ghofrani HA, Simonneau G, D’Armini AM, Fedullo P, Howard LS, Jaïs X, et al. Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study. Lancet Respir Med. 2017;5:785–94.GhofraniHASimonneauGD’ArminiAMFedulloPHowardLSJaïsXet alMacitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled studyLancet Respir Med201757859410.1016/S2213-2600(17)30305-3Search in Google Scholar
Jaïs X, D’Armini AM, Jansa P, Torbicki A, Delcroix M, Ghofrani HA, et al. Bosentan for Treatment of Inoperable Chronic Thromboembolic Pulmonary Hypertension. BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a Randomized, Placebo-Controlled Trial. J Am Coll Cardiol. 2008;52:2127–34.JaïsXD’ArminiAMJansaPTorbickiADelcroixMGhofraniHAet alBosentan for Treatment of Inoperable Chronic Thromboembolic Pulmonary HypertensionBENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a Randomized, Placebo-Controlled Trial. J Am Coll Cardiol20085221273410.1016/j.jacc.2008.08.05919095129Search in Google Scholar
Francis SH, Busch JL, Corbin JD. cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. Pharmacol Rev. 2010;62:525–63.FrancisSHBuschJLCorbinJDcGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP actionPharmacol Rev2010625256310.1124/pr.110.002907296490220716671Search in Google Scholar
Said K. Riociguat: PATENT-1 Study. Glob Cardiol Sci Pract. 2014;2014:31–5.SaidKRiociguat: PATENT-1 StudyGlob Cardiol Sci Pract2014201431510.5339/gcsp.2014.21422043025405174Search in Google Scholar
Galiè N, Olschewski H, Oudiz RJ, Torres F, Frost A, Ghofrani HA, et al. Ambrisentan for the treatment of pulmonary arterial hypertension: Results of the ambrisentan in pulmonary arterial hypertension, randomized, double-Blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2. Circulation. 2008;117:3010–19.GalièNOlschewskiHOudizRJTorresFFrostAGhofraniHAet alAmbrisentan for the treatment of pulmonary arterial hypertension: Results of the ambrisentan in pulmonary arterial hypertension, randomized, double-Blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2Circulation200811730101910.1161/CIRCULATIONAHA.107.74251018506008Search in Google Scholar
Miyauchi T, Sakai S. Endothelin and the heart in health and diseases. Peptides. 2019;111:77–88.MiyauchiTSakaiSEndothelin and the heart in health and diseasesPeptides2019111778810.1016/j.peptides.2018.10.00230352269Search in Google Scholar
Wei A, Gu Z, Li J, Liu X, Wu X, Han Y, et al. Clinical Adverse Effects of Endothelin Receptor Antagonists: Insights From the Meta-Analysis of 4894 Patients From 24 Randomized Double-Blind Placebo-Controlled Clinical Trials. J Am Heart Assoc. 2016;5:e003896.WeiAGuZLiJLiuXWuXHanYet alClinical Adverse Effects of Endothelin Receptor Antagonists: Insights From the Meta-Analysis of 4894 Patients From 24 Randomized Double-Blind Placebo-Controlled Clinical TrialsJ Am Heart Assoc20165e00389610.1161/JAHA.116.003896521031927912207Search in Google Scholar
Mitchell JA, Ahmetaj-Shala B, Kirkby NS, Wright WR, Mackenzie LS, Reed DM, et al. Role of prostacyclin in pulmonary hypertension. Glob Cardiol Sci Pract. 2014;4:382–93.MitchellJAAhmetaj-ShalaBKirkbyNSWrightWRMackenzieLSReedDMet alRole of prostacyclin in pulmonary hypertensionGlob Cardiol Sci Pract201443829310.5339/gcsp.2014.53435551325780793Search in Google Scholar
Hoeper MM, Kramer T, Pan Z, Eichstaedt CA, Spiesshoefer J, Benjamin N, et al. Mortality in pulmonary arterial hypertension: Prediction by the 2015 European pulmonary hypertension guidelines risk stratification model. Eur Respir J. 2017;50:1700740.HoeperMMKramerTPanZEichstaedtCASpiesshoeferJBenjaminNet alMortality in pulmonary arterial hypertension: Prediction by the 2015 European pulmonary hypertension guidelines risk stratification modelEur Respir J201750170074010.1183/13993003.00740-201728775047Search in Google Scholar
Benza RL, Elliott CG, Farber HW, Foreman AJ, Frost AE, Gomberg-Maitland M, et al. Updated Risk Score Calculator for Patients with Pulmonary Arterial Hypertension (PAH) in the Registry to Evaluate Early and Long-Term PAH Disease Management (REVEAL). Am J Respir Crit Care Med. 2017;195:A6899.BenzaRLElliottCGFarberHWForemanAJFrostAEGomberg-MaitlandMet alUpdated Risk Score Calculator for Patients with Pulmonary Arterial Hypertension (PAH) in the Registry to Evaluate Early and Long-Term PAH Disease Management (REVEAL)Am J Respir Crit Care Med2017195A6899Search in Google Scholar
Robitaille A, Denault AY, Couture P, Bélisle S, Fortier A, Guertin MC, et al. Importance of Relative Pulmonary Hypertension in Cardiac Surgery: The Mean Systemic-to-Pulmonary Artery Pressure Ratio. J Cardiothorac Vasc Anesth. 2006;20:331–9.RobitailleADenaultAYCouturePBélisleSFortierAGuertinMCet alImportance of Relative Pulmonary Hypertension in Cardiac Surgery: The Mean Systemic-to-Pulmonary Artery Pressure RatioJ Cardiothorac Vasc Anesth200620331910.1053/j.jvca.2005.11.01816750732Search in Google Scholar
Bapat V, Rajagopal V, Meduri C, Farivar RS, Walton A, Duffy SJ, et al. Early Experience With New Transcatheter Mitral Valve Replacement. J Am Coll Cardiol. 2018;13:344–51.BapatVRajagopalVMeduriCFarivarRSWaltonADuffySJet alEarly Experience With New Transcatheter Mitral Valve ReplacementJ Am Coll Cardiol2018133445110.1016/j.jacc.2017.10.06129102689Search in Google Scholar
Kaw R, Pasupuleti V, Deshpande A, Hamieh T, Walker E, Minai OA. Pulmonary hypertension: An important predictor of outcomes in patients undergoing non-cardiac surgery. Respir Med. 2011;105:619–24.KawRPasupuletiVDeshpandeAHamiehTWalkerEMinaiOAPulmonary hypertension: An important predictor of outcomes in patients undergoing non-cardiac surgeryRespir Med20111056192410.1016/j.rmed.2010.12.00621195595Search in Google Scholar
Lai HC, Lai HC, Wang KY, Lee WL, Ting CT, Liu TJ. Severe pulmonary hypertension complicates postoperative outcome of non-cardiac surgery. Br J Anaesth. 2007;99:184–90.LaiHCLaiHCWangKYLeeWLTingCTLiuTJSevere pulmonary hypertension complicates postoperative outcome of non-cardiac surgeryBr J Anaesth2007991849010.1093/bja/aem12617576968Search in Google Scholar
Ramakrishna G, Sprung J, Ravi BS, Chandrasekaran K, McGoon MD. Impact of pulmonary hypertension on the outcomes of noncardiac surgery: Predictors of perioperative morbidity and mortality. J Am Coll Cardiol. 2005;45:1691–9.RamakrishnaGSprungJRaviBSChandrasekaranKMcGoonMDImpact of pulmonary hypertension on the outcomes of noncardiac surgery: Predictors of perioperative morbidity and mortalityJ Am Coll Cardiol2005451691910.1016/j.accreview.2005.08.229Search in Google Scholar
Montani D, Bergot E, Günther S, Savale L, Bergeron A, Bourdin A, et al. Pulmonary arterial hypertension in patients treated by dasatinib. Circulation. 2012;70:239–43.MontaniDBergotEGüntherSSavaleLBergeronABourdinAet alPulmonary arterial hypertension in patients treated by dasatinibCirculation2012702394310.1161/CIRCULATIONAHA.111.07992122451584Search in Google Scholar
Fuster V, Steele PM, Edwards WD, Gersh BJ, McGoon MD, Frye RL. Primary pulmonary hypertension: Natural history and the importance of thrombosis. Circulation. 1984;70:580–7.FusterVSteelePMEdwardsWDGershBJMcGoonMDFryeRLPrimary pulmonary hypertension: Natural history and the importance of thrombosisCirculation198470580710.1161/01.CIR.70.4.580Search in Google Scholar
Huber K, Beckmann R, Frank H, Kneussl M, Mlczoch J, Binder BR. Fibrinogen, t-PA, and PAI-1 plasma levels in patients with pulmonary hypertension. Am J Respir Crit Care Med. 1994;150:929–33.HuberKBeckmannRFrankHKneusslMMlczochJBinderBRFibrinogen, t-PA, and PAI-1 plasma levels in patients with pulmonary hypertensionAm J Respir Crit Care Med19941509293310.1164/ajrccm.150.4.79214657921465Search in Google Scholar
Rich S, Kaufmann E, Levy PS. The Effect of High Doses of Calcium-Channel Blockers on Survival in Primary Pulmonary Hypertension. N Engl J Med. 1992;327:76–81.RichSKaufmannELevyPSThe Effect of High Doses of Calcium-Channel Blockers on Survival in Primary Pulmonary HypertensionN Engl J Med1992327768110.1056/NEJM1992070932702031603139Search in Google Scholar
Sarkar MS, Desai PM. Pulmonary hypertension and cardiac anesthesia: Anesthesiologist’s perspective. Ann Card Anaesth. 2018;21:116–22.SarkarMSDesaiPMPulmonary hypertension and cardiac anesthesia: Anesthesiologist’s perspectiveAnn Card Anaesth20182111622Search in Google Scholar
Teo YW, Greenhalgh DL. Update on anaesthetic approach to pulmonary hypertension. Eur J Anaesthesiol. 2010;24:317–23.TeoYWGreenhalghDLUpdate on anaesthetic approach to pulmonary hypertensionEur J Anaesthesiol2010243172310.1097/EJA.0b013e328335474e20010107Search in Google Scholar
Yilmaz S, Yildirim Y, Taylan M, Demir M, Yilmaz Z, Kara AV, et al. The relationship of fluid overload as assessed by bioelectrical impedance analysis with pulmonary arterial hypertension in hemodialysis patients. Med Sci Monit. 2016;22:488–494.YilmazSYildirimYTaylanMDemirMYilmazZKaraAVet alThe relationship of fluid overload as assessed by bioelectrical impedance analysis with pulmonary arterial hypertension in hemodialysis patientsMed Sci Monit20162248849410.12659/MSM.896305Search in Google Scholar
Stickel S, Gin-Sing W, Wagenaar M, Gibbs JSR. The practical management of fluid retention in adults with right heart failure due to pulmonary arterial hypertension. Eur Heart J Suppl. 2019;21:46–53.StickelSGin-SingWWagenaarMGibbsJSRThe practical management of fluid retention in adults with right heart failure due to pulmonary arterial hypertensionEur Heart J Suppl201921465310.1093/eurheartj/suz207691505531857800Search in Google Scholar
Pilkington SA, Taboada D, Martinez G. Pulmonary hypertension and its management in patients undergoing non-cardiac surgery. Anaesthesia. 2015;7:56–70.PilkingtonSATaboadaDMartinezGPulmonary hypertension and its management in patients undergoing non-cardiac surgeryAnaesthesia20157567010.1111/anae.1283125267493Search in Google Scholar
Nonaka DF, Grichnik KP, Whitener GB. Pulmonary Hypertension and Thoracic Surgery: Diagnostics and Advances in Therapy and Intraoperative Management. Curr Anesthesiol Rep. 2014;4:135–41.NonakaDFGrichnikKPWhitenerGBPulmonary Hypertension and Thoracic Surgery: Diagnostics and Advances in Therapy and Intraoperative ManagementCurr Anesthesiol Rep201441354110.1007/s40140-014-0053-xSearch in Google Scholar
J Jenkins, A Lynn, J Edmonds GB. Effects of Mechanical Ventilation on Cardiopulmonary Function in Children After Open-Heart Surgery. Crit Care Med. 1985;13:77–80.JenkinsJLynnAJEdmonds GBEffects of Mechanical Ventilation on Cardiopulmonary Function in Children After Open-Heart SurgeryCrit Care Med198513778010.1097/00003246-198502000-000043881223Search in Google Scholar
Bonnin M, Mercier FJ, Sitbon O, Roger-Christoph S, Jaïs X, Humbert M, et al. Severe pulmonary hypertension during pregnancy: Mode of delivery and anesthetic management of 15 consecutive cases. Anesthesiology. 2005;102:1133–7.BonninMMercierFJSitbonORoger-ChristophSJaïsXHumbertMet alSevere pulmonary hypertension during pregnancy: Mode of delivery and anesthetic management of 15 consecutive casesAnesthesiology20051021133710.1097/00000542-200506000-0001215915025Search in Google Scholar
Bédard E, Dimopoulos K, Gatzoulis MA. Has there been any progress made on pregnancy outcomes among women with pulmonary arterial hypertension? Eur Heart J. 2009;30:256– 65.BédardEDimopoulosKGatzoulisMAHas there been any progress made on pregnancy outcomes among women with pulmonary arterial hypertension?Eur Heart J200930256–6510.1093/eurheartj/ehn59719147605Search in Google Scholar
Martin JT, Tautz TJ, Antognini JF. Safety of regional anesthesia in Eisenmenger’s syndrome. Reg Anesth Pain Med. 2002;27:509– 13.MartinJTTautzTJAntogniniJFSafety of regional anesthesia in Eisenmenger’s syndromeReg Anesth Pain Med200227509–1310.1053/rapm.2002.3570612373701Search in Google Scholar
Warltier M.D., Ph.D., Editor DC, Campagna M.D., Ph.D. JA, Carter M.D. C. Clinical Relevance of the Bezold–Jarisch Reflex. Anesthesiol J Am Soc Anesthesiol. 2003 May 1;98:1250–60.WarltierMD.Ph.D., Editor DC, Campagna M.D., Ph.D. JA, Carter M.D. CClinical Relevance of the Bezold–Jarisch ReflexAnesthesiol J Am Soc Anesthesiol2003May 19812506010.1097/00000542-200305000-0003012717149Search in Google Scholar
Picard J, Meek T. Complications of regional anaesthesia. Anaesthesia. 2010;65:105–15.PicardJMeekTComplications of regional anaesthesiaAnaesthesia2010651051510.1111/j.1365-2044.2009.06205.x20377552Search in Google Scholar
Elgebaly A, Eldabaa A. Is I-gel airway a better option to endotracheal tube airway for sevoflurane-fentanyl anesthesia during cardiac surgery? Anesth Essays Res. 2014;8:216–22.ElgebalyAEldabaaAIs I-gel airway a better option to endotracheal tube airway for sevoflurane-fentanyl anesthesia during cardiac surgery?Anesth Essays Res201482162210.4103/0259-1162.134510417361525886229Search in Google Scholar
Grübler Martin R, Olivier W, David B, Stefan B. Basic concepts of heart-lung interactions during mechanical ventilation. Swiss Med Wkly. 2017;147:14491.GrüblerMartin ROlivierWDavidBStefanBBasic concepts of heart-lung interactions during mechanical ventilationSwiss Med Wkly20171471449110.4414/smw.2017.1449128944931Search in Google Scholar
Kerbaul F, Rondelet B, Mote S, Fesler P, Hubloue I, Ewalenko P, et al. Isoflurane and desflurane impair right ventricular-pulmonary arterial coupling in dogs. Anesthesiology. 2004;101:1357–62.KerbaulFRondeletBMoteSFeslerPHubloueIEwalenkoPet alIsoflurane and desflurane impair right ventricular-pulmonary arterial coupling in dogsAnesthesiology200410113576210.1097/00000542-200412000-0001615564943Search in Google Scholar
Wenker O. Review Of Currently Used Inhalation Anesthetics: Part II. Internet J Anesthesiol. 1998;3:1–11.WenkerOReview Of Currently Used Inhalation Anesthetics: Part IIInternet J Anesthesiol19983111Search in Google Scholar
Behnaz F, Ghasemi M, Mohseni G, Zarakim A. The efect of Sevoflurane and Propofol on pulmonary arterial pressure during cardiac catheterization in children with congenital heart diseases. World Fam Med J Fam Med Middle East J Fam Med. 1999;15:54–60.BehnazFGhasemiMMohseniGZarakimAThe efect of Sevoflurane and Propofol on pulmonary arterial pressure during cardiac catheterization in children with congenital heart diseasesWorld Fam Med J Fam Med Middle East J Fam Med1999155460Search in Google Scholar
Naguib M, Samarkandi AH, Bakhamees HS, Magboul MA, El-Bakry AK. Histamine-release haemodynamic changes produced by rocuronium, vecuronium, mivacurium, atracurium and tubocurarine. Br J Anaesth. 1995;75:588–592.NaguibMSamarkandiAHBakhameesHSMagboulMAEl-BakryAKHistamine-release haemodynamic changes produced by rocuronium, vecuronium, mivacurium, atracurium and tubocurarineBr J Anaesth19957558859210.1093/bja/75.5.5887577286Search in Google Scholar
Recommendations for standards of monitoring during anaesthesia and recovery 2015 . 2015;1:1-9Recommendations for standards of monitoring during anaesthesia and recovery 20152015119Search in Google Scholar
Cheng JW, Tonelli AR, Petersson G, Krasuski RA. Pharmacologic management of perioperative pulmonary hypertension. J Cardiovasc Pharmacol . 2014;63:375–84.ChengJWTonelliARPeterssonGKrasuskiRAPharmacologic management of perioperative pulmonary hypertensionJ Cardiovasc Pharmacol2014633758410.1097/FJC.0000000000000050398220124710471Search in Google Scholar
Hoeper MM, Granton J. Intensive care unit management of patients with severe pulmonary hypertension and right heart failure. Am J Respir Crit Care Med. 2011;184:1114–24.HoeperMMGrantonJIntensive care unit management of patients with severe pulmonary hypertension and right heart failureAm J Respir Crit Care Med201118411142410.1164/rccm.201104-0662CI21700906Search in Google Scholar
Lobato EB, Beaver T, Muehlschlegel J, Kirby DS, Klodell C, Sidi A. Treatment with phosphodiesterase inhibitors type III and V: Milrinone and sildenafil is an efective combination during thromboxane-induced acute pulmonary hypertension. Br J Anaesth. 2006;96:317–22.LobatoEBBeaverTMuehlschlegelJKirbyDSKlodellCSidiATreatment with phosphodiesterase inhibitors type III and V: Milrinone and sildenafil is an efective combination during thromboxane-induced acute pulmonary hypertensionBr J Anaesth2006963172210.1093/bja/ael00916443640Search in Google Scholar
Nieminen MS, Fruhwald S, Heunks LMA, Suominen PK, Gordon AC, Kivikko M, et al. Levosimendan: current data, clinical use and future development. Hear lung Vessel. 2013;5:227–245.NieminenMSFruhwaldSHeunksLMASuominenPKGordonACKivikkoMet alLevosimendan: current data, clinical use and future developmentHear lung Vessel20135227245Search in Google Scholar
Rabanal JM, Real MI, Williams M. Perioperative management of pulmonary hypertension during lung transplantation (a lesson for other anaesthesia setings). Rev Esp Anestesiol Reanim. 2014;61:434–45.RabanalJMRealMIWilliamsMPerioperative management of pulmonary hypertension during lung transplantation (a lesson for other anaesthesia setings)Rev Esp Anestesiol Reanim2014614344510.1016/j.redar.2014.05.01525156939Search in Google Scholar
Brunner N, de Jesus Perez VA, Richter A, Haddad F, Denault A, Rojas V, et al. Perioperative pharmacological management of pulmonary hypertensive crisis during congenital heart surgery. Pulm Circ. 2014;4:10–24.BrunnerNde JesusPerez VARichterAHaddadFDenaultARojasVet alPerioperative pharmacological management of pulmonary hypertensive crisis during congenital heart surgeryPulm Circ20144102410.1086/674885407076025006417Search in Google Scholar
Sztrymf B, Souza R, Bertoleti L, Jaïs X, Sitbon O, Price LC, et al. Prognostic factors of acute heart failure in patients with pulmonary arterial hypertension. Eur Respir J. 2010;35:1286– 1293.SztrymfBSouzaRBertoletiLJaïsXSitbonOPriceLCet alPrognostic factors of acute heart failure in patients with pulmonary arterial hypertensionEur Respir J2010351286–129310.1183/09031936.0007020919897557Search in Google Scholar
Provencher S, Herve P, Jais X, Lebrec D, Humbert M, Simonneau G, et al. Deleterious efects of β-blockers on exercise capacity and hemodynamics in patients with portopulmonary hypertension. Gastroenterology. 2006;130:120–6.ProvencherSHervePJaisXLebrecDHumbertMSimonneauGet alDeleterious efects of β-blockers on exercise capacity and hemodynamics in patients with portopulmonary hypertensionGastroenterology2006130120610.1053/j.gastro.2005.10.01316401475Search in Google Scholar
Szollosi I, Thompson BR, Krum H, Kaye DM, Naughton MT. Impaired pulmonary difusing capacity and hypoxia in heart failure correlates with central sleep apnea severity. Chest. 2008;134:67–72.SzollosiIThompsonBRKrumHKayeDMNaughtonMTImpaired pulmonary difusing capacity and hypoxia in heart failure correlates with central sleep apnea severityChest2008134677210.1378/chest.07-148718198261Search in Google Scholar
Savale L, Weatherald J, Jaïs X, Vuillard C, Boucly A, Jevnikar M, et al. Acute decompensated pulmonary hypertension. Eur Respir Rev. 2017;26:170050.SavaleLWeatheraldJJaïsXVuillardCBouclyAJevnikarMet alAcute decompensated pulmonary hypertensionEur Respir Rev20172617005010.1183/16000617.0092-201729141964Search in Google Scholar
Sharman A, Low J. Vasopressin and its role in critical care. Contin Educ Anaesthesia, Crit Care Pain. 2008;8:134–7.SharmanALowJVasopressin and its role in critical careContin Educ Anaesthesia, Crit Care Pain20088134710.1093/bjaceaccp/mkn021Search in Google Scholar
Kreider ME, Hansen-Flaschen J, Ahmad NN, Rossman MD, Kaiser LR, Kucharczuk JC, et al. Complications of Video-Assisted Thoracoscopic Lung Biopsy in Patients with Interstitial Lung Disease. Ann Thorac Surg. 2007;83:1140–4.KreiderMEHansen-FlaschenJAhmadNNRossmanMDKaiserLRKucharczukJCet alComplications of Video-Assisted Thoracoscopic Lung Biopsy in Patients with Interstitial Lung DiseaseAnn Thorac Surg2007831140410.1016/j.athoracsur.2006.10.00217307476Search in Google Scholar
Sullivan B, Puskas F, Fernandez-Bustamante A. Transesophageal Echocardiography in Noncardiac Thoracic Surgery. Anesthesiol Clin. 2012;30:657–69.SullivanBPuskasFFernandez-BustamanteATransesophageal Echocardiography in Noncardiac Thoracic SurgeryAnesthesiol Clin2012306576910.1016/B978-0-323-71301-6.00055-XSearch in Google Scholar
Zhang C, Liu Y, Qing E, Ma J. Preoperative risk factors analysis of pulmonary hypertension crisis during perioperative period for caesarean section of woman with severe pulmonary hypertension. Chinese Critical Care Medicine. 2017;29:431– 5.ZhangCLiuYQingEMaJPreoperative risk factors analysis of pulmonary hypertension crisis during perioperative period for caesarean section of woman with severe pulmonary hypertensionChinese Critical Care Medicine201729431–5Search in Google Scholar
Olsson KM, Nickel NP, Tongers J, Hoeper MM. Atrial fluter and fibrillation in patients with pulmonary hypertension. Int J Cardiol. 2013;167:2300–5.OlssonKMNickelNPTongersJHoeperMMAtrial fluter and fibrillation in patients with pulmonary hypertensionInt J Cardiol20131672300510.1016/j.ijcard.2012.06.02422727973Search in Google Scholar
Peacock A, Ross K. Pulmonary hypertension: A contraindication to the use of β-adrenoceptor blocking agents. Thorax. 2010;65:454–5.PeacockARossKPulmonary hypertension: A contraindication to the use of β-adrenoceptor blocking agentsThorax201065454510.1136/thx.2008.11195520435871Search in Google Scholar
Naeije R, Badagliacca R. The overloaded right heart and ventricular interdependence. Cardiovasc Res. 2017;113:1474– 85.NaeijeRBadagliaccaRThe overloaded right heart and ventricular interdependenceCardiovasc Res20171131474–8510.1093/cvr/cvx16028957537Search in Google Scholar
Krowka MJ, Plevak DJ, Findlay JY, Rosen CB, Wiesner RH, Krom RAF. Pulmonary hemodynamics and perioperative cardiopulmonary-related mortality in patients with portopulmonary hypertension undergoing liver transplantation. Liver Transplant. 2000;6:443–50.KrowkaMJPlevakDJFindlayJYRosenCBWiesnerRHKromRAFPulmonary hemodynamics and perioperative cardiopulmonary-related mortality in patients with portopulmonary hypertension undergoing liver transplantationLiver Transplant200064435010.1053/jlts.2000.635610915166Search in Google Scholar
Starkel P, Vera A, Gunson B, Mutimer D. Outcome of liver transplantation for patients with pulmonary hypertension. Liver Transplant. 2002;8:382–8.StarkelPVeraAGunsonBMutimerDOutcome of liver transplantation for patients with pulmonary hypertensionLiver Transplant20028382810.1053/jlts.2002.3134311965583Search in Google Scholar
Kruthiventi SC, Kane GC, Sprung J, Weingarten TN, Warner ME. Postoperative pulmonary complications in contemporary cohort of patients with pulmonary hypertension. Bosn J basic Med Sci. 2019;19:392–9.KruthiventiSCKaneGCSprungJWeingartenTNWarnerMEPostoperative pulmonary complications in contemporary cohort of patients with pulmonary hypertensionBosn J basic Med Sci201919392910.17305/bjbms.2019.4332686848831301223Search in Google Scholar
Ishikawa S , Ohtaki A, Takahashi T, Ohki S, Hasegawa Y, Yamagishi T el al. Lung Impairment Following Cardiac Surgery in Patients With Pulmonary Hypertension. J Cardiovasc Surg. 2002;43:7–10.IshikawaSOhtakiATakahashiTOhkiSHasegawaYYamagishiTel alLung Impairment Following Cardiac Surgery in Patients With Pulmonary HypertensionJ Cardiovasc Surg200243710Search in Google Scholar