| 2 hours prior to respiratory arrest (Hospital Day 6) (Capillary gas) | 7.42 | 22 | 81 | 14.2 | 8.9 |
Blood | 1 hour after respiratory arrest (Hospital Day 6) (Capillary gas) | 7.12 | 41.5 | 125 | 13.5 | 8.1 |
gases | 36 hours after initiation of Pediasure® (Hospital Day 8) (Venous gas) | 7.31 | 51.1 | 45.7 | 25.4 | 9.3 |
| After development of ARDS (Hospital Day 13) (Arterial gas) | 7.42 | 52 | 55 | 33.5 | 1.3 |
|
Serum pyruvate level (mg/dL) | 2.42 (Reference range: 0.3-1.5) |
|
Blood lactate to pyruvate ratio | 14.87 |
|
| Activated PDC level (nmol/min/mg protein) | 0.35 (Reference range: 1.2-6.52) |
Skeletal muscle biopsy | PDC/E3 ratio | 0.4 (Reference range: 0.82-4.54) |
Pyruvate dehydrogenase and mitochondrial complex panel | Positive for pyruvate dehydrogenase alpha 1 (PDHA1) gene mutation |