The aim of this study is to provide partially updated data on observational, non-interventional research that aims to determine the potential clinical and diagnostic implications of the association of bronchiectasis in patients with COPD.
Both COPD and bronchiectasis are two chronic lung diseases with a high prevalence in the general population and can coexist in a large number of cases. Their coexistence is increasingly diagnosed in clinical practice, but this association has not yet been well studied. The overlap of these two pathological entities has been established as a unique phenotype, because patients are prone to more severe and frequent exacerbations. It is therefore important to identify and study the presence of bronchiectasis in patients with COPD, as the clinical, prognostic, and therapeutic implications are different.
Patients were included in the study after an anamnesis as complete as possible and subsequent completion of the informed consent form. The ethical aspects were respected by the existence of the agreement of the Ethics Commission of the Institute of Pneumoftiziology “Marius Nasta”, Bucharest, for the study and by the presence of the informed consent of the patient (attached to each medical record / per hospitalized patient).
The comparative evaluation of the 2 groups of patients, group I (COPD) and group II (COPD and Bronchiectasis), consisted of periodic clinical-paraclinical monitoring (T0, T3, T6, T12), highlighting the negative impact of the presence of bronchiectasis in patients with COPD.
The presence of infections with potentially pathogenic microorganisms and, in particular, with Pseudomonas aeruginosa, is a variable frequently associated with the presence of bronchiectasis in patients with COPD, being considered a predictor of mortality in these patients.
Although the data obtained in this paperwork were in absolute agreement with the data of other existing studies in the literature, the number of patients included in the study was not high enough, and the pandemic context of the COVID-19 that broke out in Romania in March 2020 had quite obvious negative repercussions on the course of the study.