<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Advanced heart failure (AHF) is the stage of heart failure (HF) refractory to maximal medical treatment, cardiac devices (CRT - cardiac resynchronization, ICD - implantable defibrillator) and surgical treatment. AHF has become of interest through the experience and favorable results of treatment by mechanical circulatory support (MCS) and cardiac transplant (CT). The article reviews the criteria for defining the AHF (2018 ESC statement), natural history and prognosis outside the advanced treatment forms. Evaluation of risk and prognostic factors is required before the decision of advanced therapy: clinical factors (HF severity and reduction of cardiorespiratory functional capacity), RV function, biological markers and elements of organ dysfunction, as well as reduction of tolerance to conventional medication.</p><p>Finally, the principles of treatment and the results of mechanical circulatory support and cardiac transplant are presented.</p></abstract>

Advanced heart failure (AHF) is the stage of heart failure (HF) refractory to maximal medical treatment, cardiac devices (CRT - cardiac resynchronization, ICD - implantable defibrillator) and surgical treatment. AHF has become of interest through the experience and favorable results of treatment by mechanical circulatory support (MCS) and cardiac transplant (CT). The article reviews the criteria for defining the AHF (2018 ESC statement), natural history and prognosis outside the advanced treatment forms. Evaluation of risk and prognostic factors is required before the decision of advanced therapy: clinical factors (HF severity and reduction of cardiorespiratory functional capacity), RV function, biological markers and elements of organ dysfunction, as well as reduction of tolerance to conventional medication.Finally, the principles of treatment and the results of mechanical circulatory support and cardiac transplant are presented.

Advanced Heart Failure

Cardiology section of the University Hospital Bucharest

Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Advanced Heart Failure"}

Advanced heart failure (AHF) is the stage of heart failure (HF) refractory to maximal medical treatment, cardiac devices (CRT - cardiac resynchronization, ICD...

Advanced Heart Failure

Publié en ligne: 30 déc. 2019

Pages: 47 - 57

DOI: https://doi.org/10.2478/inmed-2019-0093

Mots clés
advanced heart failure, mechanical circulatory support, heart transplant

© 2019 Leonida Gherasim, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Advanced Heart Failure

Publié en ligne: 30 déc. 2019

Pages: 47 - 57

DOI: https://doi.org/10.2478/inmed-2019-0093

Mots clésadvanced heart failure, mechanical circulatory support, heart transplant

© 2019 Leonida Gherasim, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
advanced heart failure, mechanical circulatory support, heart transplant