Group 1 (infected - untreated) | Group 2 (IVM treated) | Group 3 (ACV treated) | Group 4 (combined treatment) | Group 5 (healthy) | P-value | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Mo | SD | Mo | SD | Mo | SD | Mo | SD | Mo | SD | ||
Body weight (g) at day 7 p.i. (subgroups, A) | 15.70a | 1.64 | 22.90b | 2.13 | 23.10b | 2.23 | 26.20c | 1.03 | 26.60c | 1.43 | < 0.001 |
Body weight (g) at day 35 p.i. (subgroups, B) | 18.20a | 2.20 | 22.30b | 2.11 | 23.70b | 2.41 | 27.00c | 1.25 | 27.30c | 1.64 | < 0.001 |
11a | 73.3% | 12a,b | 80.0% | 12a,b | 80.0% | 14a,b | 93.3% | 15b | 100.0% |
Subgroup 1B (infected untreated) | Subgroup 2B (IVM treated) | Subgroup 3B (ACV treated) | Subgroup 4B (combined treatment) | Subgroup 5B (healthy) | P-value | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Mo | SD | Mo | SD | Mo | SD | Mo | SD | Mo | SD | ||
Larva burden/LPF | 21.20a | 5.73 | 6.80b | 2.53 | 6.50b | 2.22 | 2.70b | 1.16 | NA | . | < 0.001 |
Subgroup 1A (infected untreated) | Subgroup 2A (IVM treated) | Subgroup 3 A (ACV treated) | Subgroup 4A (combined treatment) | Subgroup 5A (healthy) | P-value | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mo | SD | Mo | SD | R% | Mo | SD | R% | Mo | SD | R% | Mo | SD | ||
No. of adults / milliliter | 173.2a | 65 | 46.2b | 8.57 | 73.3% | 45.6b | 10.25 | 73.7% | 21.7b | 8.82 | 87.5% | NA | . | < 0.001 |
No. of adults / 100 villi | 30.1a | 14 | 12b | 5.08 | 60.1% | 10.10b,c | 3.93 | 66.5% | 1.8c | 1.32 | 94.02% | NA | . | < 0.001 |
Subgroup 1B (infected untreated) | Subgroup 2B (IVM treated) | Subgroup 3B (ACV treated) | Subgroup 4B (combined treatment) | Subgroup 5B (healthy) | P-value | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Count | % | Count | % | Count | % | Count | % | Count | % | |||
Larva structures | Intact | 10a | 100.0% | 5b | 50.0% | 6b | 60.0% | 0c | 0.0% | 0 | 0.0% | < 0.001 |
Altered | 0a | 0.0% | 5b | 50.0% | 4b | 40.0% | 10c | 100.0% | 0 | 0.0% | ||
Capsule inflammatory infiltration | Mild | 0a | 0.0% | 2a,b | 20.0% | 5b,c | 50.0% | 9c | 90.0% | 0 | 0.0% | < 0.001 |
moderate | 3a,b | 30.0% | 6b | 60.0% | 5a,b | 50.0% | 1a | 10.0% | 0 | 0.0% | ||
intense | 7a | 70.0% | 2b | 20.0% | 0b | 0.0% | 0b | 0.0% | 0 | 0.0% | ||
Nurse cell | intact | 10a | 100.0% | 4b | 40.0% | 5b | 50.0% | 2b | 20.0% | 0 | 0.0% | 0.001 |
altered | 0a | 0.0% | 6b | 60.0% | 5b | 50.0% | 8b | 80.0% | 0 | 0.0% |
Subgroup 1A (infected untreated) | Subgroup 2A (IVM treated) | Subgroup 3 A (ACV treated) | Subgroup4 A (combined treatment) | Subgroup 5A (healthy) | P-value | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Mo | SD | Mo | SD | Mo | SD | Mo | SD | Mo | SD | ||
V length /C depth ratio | 1.39a | 0.24 | 5.07b | 0.80 | 4.87b | 0.93 | 5.07b | 0.80 | 5.60b | 1.07 | < 0.001 |
lymphocyte counts/villus | 110.00a | 13.03 | 50.20b | 8.35 | 18.80c | 4.26 | 6.60d | 1.78 | 6.50d | 1.84 | < 0.001 |
Goblet cell counts /villus | 45.50a | 5.02 | 12.40b | 2.27 | 12.40b | 2.32 | 10.70 b,c | 1.57 | 8.60c | 0.97 | < 0.001 |
No. of Paneth cells/crypt | 16.90a | 2.18 | 6.60b | 0.97 | 6.00b | 0.82 | 5.70b | 0.82 | 5.70b | 1.49 | < 0.001 |
No. of crypts /villus | 8.30a | 1.89 | 2.30b | 0.82 | 2.40b | 0.70 | 1.60b | 0.70 | 1.50b | 0.53 | < 0.001 |
CDX2 | Cyclin D1 | CD34 | ||
---|---|---|---|---|
Body weight (g) at day 7 p.i. | Correlation Coefficient, r-value | -0.717- | -0.853- | 0.727 |
p-value | < 0.001 | < 0.001 | < 0.001 | |
No. | 50 | 50 | 50 | |
Body weight (g) at day 35 p.i. | Correlation Coefficient, r-value | -0.684- | -0.829- | 0.746 |
p-value | < 0.001 | < 0.001 | < 0.001 | |
No. | 50 | 50 | 50 | |
V length /C depth ratio | Correlation Coefficient, r-value | -0.496- | -0.609- | 0.647 |
p-value | < 0.001 | < 0.001 | < 0.001 | |
No. | 50 | 50 | 50 | |
lymphocyte counts/villus | Correlation Coefficient, r-value | 0.759 | 0.896 | -0.799- |
p-value | < 0.001 | < 0.001 | < 0.001 | |
No. | 50 | 50 | 50 | |
Goblet cell counts /villus | Correlation Coefficient, r-value | 0.731 | 0.761 | -0.718- |
p-value | < 0.001 | < 0.001 | < 0.001 | |
No. | 50 | 50 | 50 | |
No. of Paneth cells/crypt | Correlation Coefficient, r-value | 0.550 | 0.645 | -0.619- |
p-value | < 0.001 | < 0.001 | < 0.001 | |
No. | 50 | 50 | 50 | |
No. of crypts /villus | Correlation Coefficient, r-value | 0.644 | 0.714 | -0.685- |
p-value | < 0.001 | < 0.001 | < 0.001 | |
No. | 50 | 50 | 50 | |
Adult burden/milliliter at day 7 p.i. | Correlation Coefficient, r-value | 0.783 | 0.834 | -0.755- |
p-value | < 0.001 | < 0.001 | < 0.001 | |
No. | 40 | 40 | 40 | |
Adult burden/100 villi at day 7 p.i. | Correlation Coefficient, r-value | 0.770 | 0.837 | -0.736- |
p-value | < 0.001 | < 0.001 | < 0.001 | |
No. | 40 | 40 | 40 | |
larva burden/LPF at day 35 p.i. | Correlation Coefficient, r-value | 0.690 | 0.799 | -0.802- |
p-value | < 0.001 | < 0.001 | < 0.001 | |
No. | 40 | 40 | 40 |