<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>It is important to consider the use of the epigenome as source of complementary data for genome knowledge, which is suitable for the diagnosis of schistosomiasis. Usually, a laboratory diagnosis of schistosomiasis is performed by means of <bold>1</bold>. Egg detection in the stool or urine by microscopy remains with limited sensitivity; <bold>2</bold>. Immunological screening, in which positivity persists after treatment, and <bold>3</bold>. Molecular appraisals prevail over the disadvantages of the currently used methods. In this sense, molecular methodologies are being developed based on epigenetic biomarkers, aiming to improve the diagnosis of the disease and clinical treatment as early as possible to prevent the occurrence of serious liver damage.</p></abstract>

It is important to consider the use of the epigenome as source of complementary data for genome knowledge, which is suitable for the diagnosis of schistosomiasis. Usually, a laboratory diagnosis of schistosomiasis is performed by means of 1. Egg detection in the stool or urine by microscopy remains with limited sensitivity; 2. Immunological screening, in which positivity persists after treatment, and 3. Molecular appraisals prevail over the disadvantages of the currently used methods. In this sense, molecular methodologies are being developed based on epigenetic biomarkers, aiming to improve the diagnosis of the disease and clinical treatment as early as possible to prevent the occurrence of serious liver damage.

Epigenetic markers associated with schistosomiasis

Helminthologia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Epigenetic markers associated with schistosomiasis"}

It is important to consider the use of the epigenome as source of complementary data for genome knowledge, which is suitable for the diagnosis of...

Epigenetic markers associated with schistosomiasis

Article Category: Minireview

Publié en ligne: 10 févr. 2021

Pages: 28 - 40

Reçu: 18 févr. 2020

Accepté: 01 déc. 2020

DOI: https://doi.org/10.2478/helm-2021-0009

Mots clés
Schistosomiasis, DNA methylation, histone modification, miRNAs, epigenetic markers

© 2021 R. A. Gomes Assenço, E. Alves Mota, V. F. De Oliveira, W. De Castro Borges, R. Guerra-Sá, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Epigenetic markers associated with schistosomiasis

Article Category: Minireview

Publié en ligne: 10 févr. 2021

Pages: 28 - 40

Reçu: 18 févr. 2020

Accepté: 01 déc. 2020

DOI: https://doi.org/10.2478/helm-2021-0009

Mots clésSchistosomiasis, DNA methylation, histone modification, miRNAs, epigenetic markers

© 2021 R. A. Gomes Assenço, E. Alves Mota, V. F. De Oliveira, W. De Castro Borges, R. Guerra-Sá, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
Schistosomiasis, DNA methylation, histone modification, miRNAs, epigenetic markers