<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The skin provides protective functions, such as thermoregulation, resorption, provision of immune responses, storage and sensory functions, which all play an important role in the internal stability of the organism. The skin has 3 major layers: the epidermis, the dermis and subcutis. The outermost protective layer of the epidermis, the stratum corneum, consists of 20 to 30 overlapping layers of anucleate cells, the corneocytes. Ichthyosis is an autosomal recessive congenital skin disease, in which the corneocytes form defects that appear like individual steps of the stratum corneum. Ichthyosis is characterized by excessive scaling over the entire body surface and is not curable; the symptoms can only be alleviated. Several genetic variants have been identified in specific dog breeds: <italic>PNPLA1</italic> in the Golden Retrievers, <italic>SLC27A4</italic> in the Great Danes, <italic>NIPAL4</italic> in the American Bulldogs, <italic>TGM1</italic> in the Jack Russel Terriers, <italic>ASPRV1</italic> in the German Shepherds, which cause different forms of nonepidermolytic ichthyosis and <italic>KRT10</italic> in the Norfolk Terriers, which causes epidermolytic ichthyosis. When classifying breeds of dogs predisposed to ichthyosis, it is necessary to determine the presence of defective genes in the genome of the individual animals involved in mating.</p>
</abstract>

The skin provides protective functions, such as thermoregulation, resorption, provision of immune responses, storage and sensory functions, which all play an important role in the internal stability of the organism. The skin has 3 major layers: the epidermis, the dermis and subcutis. The outermost protective layer of the epidermis, the stratum corneum, consists of 20 to 30 overlapping layers of anucleate cells, the corneocytes. Ichthyosis is an autosomal recessive congenital skin disease, in which the corneocytes form defects that appear like individual steps of the stratum corneum. Ichthyosis is characterized by excessive scaling over the entire body surface and is not curable; the symptoms can only be alleviated. Several genetic variants have been identified in specific dog breeds: PNPLA1 in the Golden Retrievers, SLC27A4 in the Great Danes, NIPAL4 in the American Bulldogs, TGM1 in the Jack Russel Terriers, ASPRV1 in the German Shepherds, which cause different forms of nonepidermolytic ichthyosis and KRT10 in the Norfolk Terriers, which causes epidermolytic ichthyosis. When classifying breeds of dogs predisposed to ichthyosis, it is necessary to determine the presence of defective genes in the genome of the individual animals involved in mating.

Ichthyosis in Dogs—Congenital Dermatologic Disorder

Department of Pharmacology and Toxicology

University of Veterinary Medicine and Pharmacy in Košice

Folia Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Ichthyosis in Dogs\u2014Congenital Dermatologic Disorder"}

The skin provides protective functions, such as thermoregulation, resorption, provision of immune responses, storage and sensory functions, which all play an...

Ichthyosis in Dogs—Congenital Dermatologic Disorder

Publié en ligne: 05 oct. 2021

Pages: 22 - 29

Reçu: 10 juin 2021

Accepté: 03 août 2021

DOI: https://doi.org/10.2478/fv-2021-0024

Mots clés
dog, gene, hereditary disease, keratin, skin

© 2021 Z. Malinovská et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Ichthyosis in Dogs—Congenital Dermatologic Disorder

Publié en ligne: 05 oct. 2021

Pages: 22 - 29

Reçu: 10 juin 2021

Accepté: 03 août 2021

DOI: https://doi.org/10.2478/fv-2021-0024

Mots clésdog, gene, hereditary disease, keratin, skin

© 2021 Z. Malinovská et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
dog, gene, hereditary disease, keratin, skin