<abstract xmlns="http://www.w3.org/1999/xhtml">This investigation estimated the anti-oxidative potential of <italic>Aloe barbadensis</italic> gel extracts in rats against alcohol-induced oxidative stress. Thirty male albino rats (5 each per group) were included in the experiments. Group A (positive control) and B (negative control) were administered 4 mg.kg–1 body weight distilled water and 50 % alcohol respectively for 21 days. Groups C and D were administered 50 % alcohol for the first 14 days followed by co-administration of 125 mg and 250 mg.kg−1 body weight extract with alcohol respectively for the last 7 days. Groups E and F were administered distilled water for the first 14 days followed by co-administration of 125 and 250 mg.kg−1 body weight <italic>Aloe barbadensis</italic> gel extracts with distilled water respectively for the last 7 days. The administration of alcohol resulted in a significant (P &lt; 0.05) decrease in the specific activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) levels, while cholesterol (CHO), triglycerides (TAG), nitric oxide (NO) and malondialdehyde (MDA) concentrations were significantly increased when compared to the controls. Co-mobilization with <italic>Aloe barbadensis</italic> gel extracts for 7 days significantly reversed the deleterious effects of alcohol in the treated groups when compared to the alcohol group. This study indicated that <italic>Aloe barbadensis</italic> probably possesses anti-oxidative effects against alcohol–induced oxidative stress in rats.</abstract>

This investigation estimated the anti-oxidative potential of Aloe barbadensis gel extracts in rats against alcohol-induced oxidative stress. Thirty male albino rats (5 each per group) were included in the experiments. Group A (positive control) and B (negative control) were administered 4 mg.kg–1 body weight distilled water and 50 % alcohol respectively for 21 days. Groups C and D were administered 50 % alcohol for the first 14 days followed by co-administration of 125 mg and 250 mg.kg−1 body weight extract with alcohol respectively for the last 7 days. Groups E and F were administered distilled water for the first 14 days followed by co-administration of 125 and 250 mg.kg−1 body weight Aloe barbadensis gel extracts with distilled water respectively for the last 7 days. The administration of alcohol resulted in a significant (P < 0.05) decrease in the specific activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) levels, while cholesterol (CHO), triglycerides (TAG), nitric oxide (NO) and malondialdehyde (MDA) concentrations were significantly increased when compared to the controls. Co-mobilization with Aloe barbadensis gel extracts for 7 days significantly reversed the deleterious effects of alcohol in the treated groups when compared to the alcohol group. This study indicated that Aloe barbadensis probably possesses anti-oxidative effects against alcohol–induced oxidative stress in rats.

Appraisal of the Antioxidative Potential of <italic>Aloe Barbadensis</italic> M. on Alcohol-Induced Oxidative Stress

Department of Biochemistry, College of Biosciences

Folia Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Appraisal of the Antioxidative Potential of  M. on Alcohol-Induced Oxidative Stress

This investigation estimated the anti-oxidative potential of Aloe barbadensis gel extracts in rats against alcohol-induced oxidative stress. Thirty male albino...

Appraisal of the Antioxidative Potential of Aloe Barbadensis M. on Alcohol-Induced Oxidative Stress

Publié en ligne: 28 sept. 2019

Pages: 34 - 46

Reçu: 27 avr. 2019

Accepté: 15 juil. 2019

DOI: https://doi.org/10.2478/fv-2019-0025

Mots clés
alcohol, antioxidant, free radicals, lipid, oxidative stress

© 2019 D. I. Akinloye et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Appraisal of the Antioxidative Potential of Aloe Barbadensis M. on Alcohol-Induced Oxidative Stress

Publié en ligne: 28 sept. 2019

Pages: 34 - 46

Reçu: 27 avr. 2019

Accepté: 15 juil. 2019

DOI: https://doi.org/10.2478/fv-2019-0025

Mots clésalcohol, antioxidant, free radicals, lipid, oxidative stress

© 2019 D. I. Akinloye et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
alcohol, antioxidant, free radicals, lipid, oxidative stress