<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Ewing sarcoma (ES) is an uncommon malignant neoplasm, mostly affecting young adults and adolescents. Surgical excision, irradiation, and combinations of multiple chemotherapeutic agents are currently used as a multimodal strategy for the treatment of local and oligometastatic disease. Although ES usually responds to the primary treatment, relapsed and primarily refractory disease remains a difficult therapeutic challenge. The growing understanding of cancer biology and the subsequent development of new therapeutic strategies have been put at the service of research in recurrent and refractory ES, generating a great number of ongoing studies with compounds that could find superior clinical outcomes in the years to come. This review gathers the current available information on the treatment and clinical investigation of ES and aims to be a point of support for future research.</p>
</abstract>

Ewing sarcoma (ES) is an uncommon malignant neoplasm, mostly affecting young adults and adolescents. Surgical excision, irradiation, and combinations of multiple chemotherapeutic agents are currently used as a multimodal strategy for the treatment of local and oligometastatic disease. Although ES usually responds to the primary treatment, relapsed and primarily refractory disease remains a difficult therapeutic challenge. The growing understanding of cancer biology and the subsequent development of new therapeutic strategies have been put at the service of research in recurrent and refractory ES, generating a great number of ongoing studies with compounds that could find superior clinical outcomes in the years to come. This review gathers the current available information on the treatment and clinical investigation of ES and aims to be a point of support for future research.

Systemic Treatment of Ewing Sarcoma: Current Options and Future Perspectives

Division of Medical Oncology & Hematopoietic Cell Transplant Unit, Department of Medicine

Second Propaedeutic Department of Medicine

Forum of Clinical Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Systemic Treatment of Ewing Sarcoma: Current Options and Future Perspectives"}

Ewing sarcoma (ES) is an uncommon malignant neoplasm, mostly affecting young adults and adolescents. Surgical excision, irradiation, and combinations of...

Systemic Treatment of Ewing Sarcoma: Current Options and Future Perspectives

Article Category: Research Article

Publié en ligne: 01 févr. 2022

Pages: 3 - 27

Reçu: 13 juil. 2020

Accepté: 09 janv. 2021

DOI: https://doi.org/10.2478/fco-2021-0005

Mots clés
Ewing sarcoma, chemotherapy, systemic treatment

© 2021 Jose Duran Moreno et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Systemic Treatment of Ewing Sarcoma: Current Options and Future Perspectives

Article Category: Research Article

Publié en ligne: 01 févr. 2022

Pages: 3 - 27

Reçu: 13 juil. 2020

Accepté: 09 janv. 2021

DOI: https://doi.org/10.2478/fco-2021-0005

Mots clésEwing sarcoma, chemotherapy, systemic treatment

© 2021 Jose Duran Moreno et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
Ewing sarcoma, chemotherapy, systemic treatment