[
Alimohammadi E, Bagheri SR, Salehi AS, Rizevandi P, Rezaie Z, Abdi A. Prognostic factors in patients with glioblastoma multiforme: focus on the pathologic variants. Acta Neurol Belg 120, 1341–1350, 2020.10.1007/s13760-019-01171-x31222512
]Search in Google Scholar
[
Almanza A, Carlesso A, Chintha C, Creedican S, Doultsinos D, Leuzzi B, Luis A, McCarthy N, Montibeller L, More S, Papaioannou A, Puschel F, Sassano ML, Skoko J, Agostinis P, de Belleroche J, Eriksson LA, Fulda S, Gorman AM, Healy S, Kozlov A, Munoz-Pinedo C, Rehm M, Chevet E, Samali A. Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications. FEBS J 286, 241–278, 2019.10.1111/febs.14608737963130027602
]Search in Google Scholar
[
Auf G, Jabouille A, Guerit S, Pineau R, Delugin M, Bouchecareilh M, Favereaux A, Maitre M, Gaiser T, von Deimling A, Czabanka M, Vajkoczy P, Chevet E, Bikfalvi A, Moenner M. A shift from an angiogenic to invasive phenotype induced in malignant glioma by inhibition of the unfolded protein response sensor IRE1. Proc Natl Acad Sci USA 107, 15553–15558, 2010.10.1073/pnas.0914072107293260020702765
]Search in Google Scholar
[
Auf G, Jabouille A, Delugin M, Guerit S, Pineau R, North S, Platonova N, Maitre M, Favereaux A, Vajkoczy P, Seno M, Bikfalvi A, Minchenko D, Minchenko O, Moenner M. High epiregulin expression in human U87 glioma cells relies on IRE1alpha and promotes autocrine growth through EGF receptor. BMC Cancer 13, 597, 2013.10.1186/1471-2407-13-597387867024330607
]Search in Google Scholar
[
Awale S, Lu J, Kalauni SK, Kurashima Y, Tezuka Y, Kadota S, Esumi H. Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. Cancer Res 66, 1751–1757, 2006.10.1158/0008-5472.CAN-05-314316452235
]Search in Google Scholar
[
Babady NE, Pang YP, Elpeleg O, Isaya G. Cryptic proteolytic activity of dihydrolipoamide dehydrogenase. Proc Natl Acad Sci USA 104, 6158–6163, 2007.10.1073/pnas.0610618104185106917404228
]Search in Google Scholar
[
Bravo R, Parra V, Gatica D, Rodriguez AE, Torrealba N, Paredes F, Wang ZV, Zorzano A, Hill JA, Jaimovich E, Quest AF, Lavandero S. Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration. Int Rev Cell Mol Biol 301, 215–290, 2013.10.1016/B978-0-12-407704-1.00005-1366655723317820
]Search in Google Scholar
[
Cai Z, Li CF, Han F, Liu C, Zhang A, Hsu CC, Peng D, Zhang X, Jin G, Rezaeian AH, Wang G, Zhang W, Pan BS, Wang CY, Wang YH, Wu SY, Yang SC, Hsu FC, D’Agostino RB Jr, Furdui CM, Kucera GL, Parks JS, Chilton FH, Huang CY, Tsai FJ, Pasche B, Watabe K, Lin HK. Phosphorylation of PDHA by AMPK drives TCA cycle to promote cancer metastasis. Mol Cell 80, 263–278, 2020.10.1016/j.molcel.2020.09.018753473533022274
]Search in Google Scholar
[
Chen R, Xiao M, Gao H, Chen Y, Li Y, Liu Y, Zhang N. Identification of a novel mitochondrial interacting protein of C1QBP using subcellular fractionation coupled with CoIP-MS. Anal Bioanal Chem 408, 1557–1564, 2016.10.1007/s00216-015-9228-726753982
]Search in Google Scholar
[
Colombo SL, Palacios-Callender M, Frakich N, Carcamo S, Kovacs I, Tudzarova S, Moncada S. Molecular basis for the differential use of glucose and glutamine in cell proliferation as revealed by synchronized HeLa cells. Proc Natl Acad Sci USA 108, 21069–21074, 2011.10.1073/pnas.1117500108324854322106309
]Search in Google Scholar
[
DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA 104, 19345–19350, 2007.10.1073/pnas.0709747104214829218032601
]Search in Google Scholar
[
Doultsinos D, Avril T, Lhomond S, Dejeans N, Guedat P, Chevet E. Control of the unfolded protein response in health and disease. SLAS Discov 22, 787–800, 2017.10.1177/247255521770168528453376
]Search in Google Scholar
[
Drogat B, Bouchecareilh M, North S, Petibois C, Deleris G, Chevet E, Bikfalvi A, Moenner M. Acute L-glutamine deprivation compromises VEGF-a upregulation in A549/8 human carcinoma cells. J Cell Physiol 212, 463–472, 2007.10.1002/jcp.2104417348020
]Search in Google Scholar
[
Eastlack SC, Dong S, Ivan C, Alahari SK. Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer. Mol Cancer 17, 100, 2018.10.1186/s12943-018-0851-8604870830012170
]Search in Google Scholar
[
Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, Zeller KI, De Marzo AM, Van Eyk JE, Mendell JT, Dang CV. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 458, 762–765, 2009.10.1038/nature07823272944319219026
]Search in Google Scholar
[
He Y, Fan Q, Cai T, Huang W, Xie X, Wen Y, Shi Z. Molecular mechanisms of the action of Arctigenin in cancer. Biomed Pharmacother 108, 403–407, 2018.10.1016/j.biopha.2018.08.15830236849
]Search in Google Scholar
[
Hetz C, Axten JM, Patterson JB. Pharmacological targeting of the unfolded protein response for disease intervention. Nat Chem Biol 15, 764–775, 2019.10.1038/s41589-019-0326-231320759
]Search in Google Scholar
[
Inoue J, Kishikawa M, Tsuda H, Nakajima Y, Asakage T, Inazawa J. Identification of PDHX as a metabolic target for esophageal squamous cell carcinoma. Cancer Sci 112, 2792–2802, 2021.10.1111/cas.14938825326933964039
]Search in Google Scholar
[
Jin Y, Cai Q, Shenoy AK, Lim S, Zhang Y, Charles S, Tarrash M, Fu X, Kamarajugadda S, Trevino JG, Tan M, Lu J. Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyro-sine-289 phosphorylation. Oncotarget 7, 25113–25124, 2016.10.18632/oncotarget.7159504189226848621
]Search in Google Scholar
[
Kim JY, Hwang JH, Cha MR, Yoon MY, Son ES, Tomida A, Ko B, Song SW, Shin-ya K, Hwang YI, Park HR. Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity. J Cell Physiol 224, 33–40, 2010.10.1002/jcp.2208520232300
]Search in Google Scholar
[
Krasnytska DA, Khita OO, Tsymbal DO, Luzina OY, Cherednychenko AA, Kozynkevych HE, Bezrodny BH, Minchenko DO. The impact of glutamine deprivation on the expression of MEIS3, SPAG4, LHX1, LHX2, and LHX6 genes in ERN1 knockdown U87 glioma cells. Endocr Reg 56, 38–47, 2022.10.2478/enr-2022-000535180817
]Search in Google Scholar
[
Logue SE, McGrath EP, Cleary P, Greene S, Mnich K, Almanza A, Chevet E, Dwyer RM, Oommen A, Legembre P, Godey F, Madden EC, Leuzzi B, Obacz J, Zeng Q, Patterson JB, Jager R, Gorman AM, Samali A. Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. Nat Commun 9, 3267, 2018.10.1038/s41467-018-05763-8609393130111846
]Search in Google Scholar
[
Manie SN, Lebeau J, Chevet E. Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 3. Orchestrating the unfolded protein response in oncogenesis: an update. Am J Physiol Cell Physiol 307, C901–C907, 2014.10.1152/ajpcell.00292.201425186011
]Search in Google Scholar
[
Mathias RA, Greco TM, Oberstein A, Budayeva HG, Chakrabarti R, Rowland EA, Kang Y, Shenk T, Cristea IM. Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Cell 159, 1615–1625, 2014.10.1016/j.cell.2014.11.046434412125525879
]Search in Google Scholar
[
Minchenko DO, Kharkova AP, Hubenia OV, Minchenko OH. Insulin receptor, IRS1, IRS2, INSIG1, INSIG2, RRAD, and BAIAP2 gene expressions in glioma U87 cells with ERN1 loss of function: effect of hypoxia and gluta-mine or glucose deprivation. Endocr Reg 47, 15–26, 2013.10.4149/endo_2013_01_1523363253
]Search in Google Scholar
[
Minchenko DO, Danilovskyi SV, Kryvdiuk IV, Bakalets TV, Lypova NM, Karbovskyi LL, Minchenko OH. Inhibition of ERN1 modifies the hypoxic regulation of the expression of TP53-related genes in U87 glioma cells. Endoplasm Reticul Stress Dis 1, 18–26, 2014.10.2478/ersc-2014-0001
]Search in Google Scholar
[
Minchenko DO, Kharkova AP, Tsymbal DO, Karbovskyi LL, Minchenko OH. IRE1 inhibition affects the expression of insulin-like growth factor binding protein genes and modifies its sensitivity to glucose deprivation in U87 glioma cells. Endocr Reg 49, 185–197, 2015a.10.4149/endo_2015_04_18526494037
]Search in Google Scholar
[
Minchenko OH, Tsymbal DO, Moenner M, Kovalevska OV, Lypova NM. Inhibition of the endoribonuclease of ERN1 signaling enzyme affects the expression of proliferation-related genes in U87 glioma cells. Endoplasm Reticul Stress Dis 2, 18–29, 2015b.10.1515/ersc-2015-0002
]Search in Google Scholar
[
Minchenko OH, Tsymbal DO, Minchenko DO, Hnatiuk OS, Prylutskyy YI, Prylutska SV, Tsierkezos NG, Ritter U. Single-walled carbon nanotubes affect the expression of genes associated with immune response in normal human astrocytes. Toxicology in vitro 52, 122–130, 2018.10.1016/j.tiv.2018.06.01129906516
]Search in Google Scholar
[
Minchenko DO, Khita OO, Tsymbal DO, Danilovskyi SV, Rudnytska OV, Halkin OV, Kryvdiuk IV, Smeshkova MV, Yakymchuk MM, Bezrodnyi BH, Minchenko OH. Expression of IDE and PITRM1 genes in IRE1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation. Endocr Reg 54, 183–195, 2020.10.2478/enr-2020-002132857715
]Search in Google Scholar
[
Minchenko DO, Khita OO, Tsymbal DO, Viletska YM, Sliusar MY, Yefimova YV, Levadna LO, Krasnytska DA, Minchenko OH. ERN1 knockdown modifies the impact of glucose and glutamine deprivations on the expression of EDN1 and its receptors in glioma cells. Endocr Reg 55, 72‒82, 2021.10.2478/enr-2021-000934020533
]Search in Google Scholar
[
Obacz J, Avril T, Le Reste PJ, Urra H, Quillien V, Hetz C, Chevet E. Endoplasmic reticulum proteostasis in glioblastoma-From molecular mechanisms to therapeutic perspectives. Sci Signal 10, eaal2323, 2017.10.1126/scisignal.aal232328292956
]Search in Google Scholar
[
Papaioannou A, Chevet E. Driving cancer tumorigenesis and metastasis through UPR signaling. Curr Top Microbiol Immunol 414, 159–192, 2018.10.1007/82_2017_3628710693
]Search in Google Scholar
[
Riabovol OO, Tsymbal DO, Minchenko DO, Lebid-Biletska KM, Sliusar MY, Rudnytska OV, Minchenko OH. Effect of glucose deprivation on the expression of genes encoding glucocorticoid receptor and some related factors in ERN1-knockdown U87 glioma cells. Endocr Regul 53, 237–249, 2019.10.2478/enr-2019-002431734653
]Search in Google Scholar
[
Shin D, Lee J, You JH, Kim D, Roh JL. Dihydrolipoamide dehydrogenase regulates cysteine deprivation-induced ferroptosis in head and neck cancer. Redox Biol 30, 101418, 2020.10.1016/j.redox.2019.101418695784131931284
]Search in Google Scholar
[
Tsymbal DO, Minchenko DO, Kryvdiuk IV, Riabovol OO, Halkin OV, Ratushna OO, Minchenko OH. Expression of proliferation related transcription factor genes in U87 glioma cells with IRE1 knockdown upon glucose and glutamine deprivation. Fiziol Zh 62, 3–15, 2016.10.15407/fz62.01.00329537195
]Search in Google Scholar
[
Tsymbal DO, Minchenko DO, Khita OO, Rudnytska OV, Viletska YM, Lahanovska YO, He Q, Liu K, Minchenko OH. ERN1 knockdown modifies the effect of glucose deprivation on homeobox gene expressions in U87 glioma cells. Endocr Regul 54, 196–206, 2020.10.2478/enr-2020-002232857719
]Search in Google Scholar
[
Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, Thompson CB. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci USA 105, 18782–18787, 2008.10.1073/pnas.0810199105259621219033189
]Search in Google Scholar
[
Xu X, Li J, Sun X, Guo Y, Chu D, Wei L, Li X, Yang G, Liu X, Yao L, Zhang J, Shen L. Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression. Oncotarget 6, 26161–26176, 2015.10.18632/oncotarget.4544469489326317652
]Search in Google Scholar
[
Yetkin-Arik B, Vogels IMC, Nowak-Sliwinska P, Weiss A, Houtkooper RH, Van Noorden CJF, Klaassen I, Schlingemann RO. The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis. Sci Rep 9, 12608, 2019.10.1038/s41598-019-48676-2671720531471554
]Search in Google Scholar
[
Yonashiro R, Eguchi K, Wake M, Takeda N, Nakayama K. Pyruvate dehydrogenase PDH-E1beta controls tumor progression by altering the metabolic status of cancer cells. Cancer Res 78, 1592–1603, 2018.10.1158/0008-5472.CAN-17-175129436427
]Search in Google Scholar
[
Zaher DM, Talaat IM, Hussein A, Hachim MY, Omar HA. Differential expression of pyruvate dehydrogenase E1A and its inactive phosphorylated form among breast cancer subtypes. Life Sci 284, 119885, 2021.10.1016/j.lfs.2021.11988534384830
]Search in Google Scholar
[
Zhao S, Cai J, Li J, Bao G, Li D, Li Y, Zhai X, Jiang C, Fan L. Bioinformatic profiling identifies a glucose-related risk signature for the malignancy of glioma and the survival of patients. Mol Neurobiol 54, 8203–8210, 2017.10.1007/s12035-016-0314-427900679
]Search in Google Scholar
