<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>It is apparent that the c-Fos and FosB/ΔFosB immunohistochemistry has generally become a useful tool for determining the different antipsychotic (AP) drugs activities in the brain. It is also noteworthy that there are no spatial limits, while to the extent of their identification over the whole brain axis. In addition, they can be in a parallel manner utilized in the unmasking of the brain cell phenotype character activated by APs and by this way also to identify the possible brain circuits underwent to the APs action. However, up to date, the number of APs involved in the extra-striatal studies is still limited, what prevents the possibility to fully understand their extra-striatal effects as a complex as well as differentiate their extra-striatal impact in qualitative and quantitative dimensions. Actually, it is very believable that more and more anatomical/functional knowledge might bring new insights into the APs extra-striatal actions by identifying new region-specific activities of APs as well as novel cellular targets affected by APs, which might reveal more details of their possible side effects of the extra-striatal origin.</p>
</abstract>

It is apparent that the c-Fos and FosB/ΔFosB immunohistochemistry has generally become a useful tool for determining the different antipsychotic (AP) drugs activities in the brain. It is also noteworthy that there are no spatial limits, while to the extent of their identification over the whole brain axis. In addition, they can be in a parallel manner utilized in the unmasking of the brain cell phenotype character activated by APs and by this way also to identify the possible brain circuits underwent to the APs action. However, up to date, the number of APs involved in the extra-striatal studies is still limited, what prevents the possibility to fully understand their extra-striatal effects as a complex as well as differentiate their extra-striatal impact in qualitative and quantitative dimensions. Actually, it is very believable that more and more anatomical/functional knowledge might bring new insights into the APs extra-striatal actions by identifying new region-specific activities of APs as well as novel cellular targets affected by APs, which might reveal more details of their possible side effects of the extra-striatal origin.

Extra-forebrain impact of antipsychotics indicated by c-Fos or FosB/ΔFosB expression: A minireview

Endocrine Regulations

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

It is apparent that the c-Fos and FosB/ΔFosB immunohistochemistry has generally become a useful tool for determining the different antipsychotic (AP) drugs...

Extra-forebrain impact of antipsychotics indicated by c-Fos or FosB/ΔFosB expression: A minireview

Publié en ligne: 21 mai 2021

Pages: 120 - 130

DOI: https://doi.org/10.2478/enr-2021-0013

Mots clés
antipsychotics, c-Fos, FosB/ΔFosB, brain extra-forebrain structures

© 2021 Alexander Kiss et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Extra-forebrain impact of antipsychotics indicated by c-Fos or FosB/ΔFosB expression: A minireview

Publié en ligne: 21 mai 2021

Pages: 120 - 130

DOI: https://doi.org/10.2478/enr-2021-0013

Mots clésantipsychotics, c-Fos, FosB/ΔFosB, brain extra-forebrain structures

© 2021 Alexander Kiss et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
antipsychotics, c-Fos, FosB/ΔFosB, brain extra-forebrain structures