Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease

Ali O. Genetics of type 2 diabetes. World J Diabetes 4,114–123, 2013.10.4239/wjd.v4.i4.114374608323961321Open DOISearch in Google Scholar

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 36, S67–S74, 2013.10.2337/dc13-S067353727323264425Search in Google Scholar

Assmann TS, Duarte GCK, Rheinheimer J, Cruz LA, Canani LH and Crispim D. The TCF7L2 rs7903146 (C/T) polymorphism is associated with risk to type 2 diabetes mellitus in Southern-Brazil. Arq Bras Endocrinol Metabol 58, 918–925, 2014.10.1590/0004-273000000351025627047Search in Google Scholar

Barros CMAR, Araujo-Neto AP, Lopes TR, Barros MAL, Motta FJN, Canalle R, Nunes LCC, Rey JA, Burbano RR, Lima-Barros MA, Yoshioka FK, Pinto GR. Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil. Genet Mol Res 13, 7889–7898, 2014.10.4238/2014.September.29.125299103Search in Google Scholar

Bielinski SJ, Pankow JS, Folsom AR, North KE and Boerwinkle E. TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study. Diabetologia 51, 968–970, 2008.10.1007/s00125-008-1004-1259720318437354Open DOISearch in Google Scholar

Cauchi S, El Achhab Y, Choquet H, Dina C, Krempler F, Weitgasser R, Nejjari C, Patsch W, Chikri M, Meyre D, Froguel P. TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. J Mol Med 85, 777–782, 2007.10.1007/s00109-007-0203-417476472Search in Google Scholar

Chauhan G, Spurgeon CJ, Tabassum R, Bhaskar S, Kulkarni SR, Mahajan A, Chavali S, Kumar MV, Prakash S, Dwivedi OP, Ghosh S, Yajnik CS, Tandon N, Bharadwaj D, Chandak GR. Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians. Diabetes 59, 2068–2074, 2010.10.2337/db09-1386291105120424228Search in Google Scholar

Dawson K, Aflaki M, Nattel S. Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential. J Physiol 591, 1409–1432, 2013.10.1113/jphysiol.2012.235382360716323207593Search in Google Scholar

de Melo SF, Frigeri HR, dos Santos-Weiss ICR, Rea RR, de Souza EM, Alberton D, Gomes de Moraes Rego F, PichethSearch in Google Scholar

G. Polymorphisms in FTO and TCF7L2 genes of Euro-Brazilian women with gestational diabetes. Clin Biochem 48, 1064–1067, 2015.10.1016/j.clinbiochem.2015.06.01326102344Search in Google Scholar

Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38, 320–323, 2006.10.1038/ng173216415884Open DOISearch in Google Scholar

Jin T. The WNT signalling pathway and diabetes mellitus. Diabetologia 51, 1771–1780, 2008.10.1007/s00125-008-1084-y1869604918696049Open DOISearch in Google Scholar

Lahiri DK, Nurnberger JI Jr. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 19, 5444, 1991.10.1093/nar/19.19.544416815113289201681511Open DOISearch in Google Scholar

Liu Z, Habener JF. Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J Biol Chem 283, 8723–8735, 2008.10.1074/jbc.M706105200241716618216022Search in Google Scholar

Long J, Edwards T, Signorello LB, Cai Q, Zheng W, Shu XO, Blot WJ. Evaluation of genome-wide association study-identified type 2 diabetes loci in African Americans. Am J Epidemiol 176, 995–1001, 2012.10.1093/aje/kws176357124323144361Search in Google Scholar

Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjogren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117, 2155–2163, 2007.10.1172/JCI30706193459617671651Search in Google Scholar

MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17, 9–26, 2009.1961948810.1016/j.devcel.2009.06.016286148519619488Search in Google Scholar

Marquezine G, Pereira A, Sousa A, Mill J, Hueb W, Krieger J. TCF7L2 variant genotypes and type 2 diabetes risk in Brazil: significant association, but not a significant tool for risk stratification in the general population. BMC Med Genet 9, 106, 2008.10.1186/1471-2350-9-106263265919055834Open DOISearch in Google Scholar

Muendlein A, Saely CH, Geller-Rhomberg S, Sonderegger G, Rein P, Winder T, Beer S, Vonbank A, Drexel H. Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosis. PLoS One 6, e17978, 2011.10.1371/journal.pone.0017978305805921423583Search in Google Scholar

Palsgaard J, Emanuelli B, Winnay JN, Sumara G, Karsenty G, Kahn CR. Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5). J Biol Chem 287, 12016–12026, 2012.10.1074/jbc.M111.337048332094822337886Search in Google Scholar

Rulifson IC, Karnik SK, Heiser PW, ten Berge D, Chen H, Gu X, Taketo MM, Nusse R, Hebrok M, Kim SK. Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci 104, 6247–6252, 2007.10.1073/pnas.0701509104184745517404238Open DOISearch in Google Scholar

Schafer SA, Tschritter O, Machicao F, Thamer C, Stefan N, Gallwitz B, Holst JJ, Dekker JM, ‘t Hart LM, Nijpels G, vanSearch in Google Scholar

Haeften TW, Haring HU, Fritsche A. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia 50, 2443–2450, 2007.10.1007/s00125-007-0753-6206356317661009Search in Google Scholar

Schinner S, Ulgen F, Papewalis C, Schott M, Woelk A, Vidal-Puig A, Scherbaum WA. Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules. Diabetologia 51, 147–154, 2007.1799421710.1007/s00125-007-0848-017994217Search in Google Scholar

Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316, 1341–1345, 2007.10.1126/science.1142382321461717463248Search in Google Scholar

Sousa AGP, Marquezine GF, Lemos PA, Martinez E, Lopes N, Hueb WA, Krieger JE, Pereira AC. TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality. PLoS One 4, e7697, 2009.10.1371/journal.pone.0007697277342519924244Search in Google Scholar

Szabo M, Mate B, Csep K, Benedek T. Genetic approaches to the study of gene variants and their impact on the patho-physiology of type 2 diabetes. Biochem Genet 56, 22–55, 2018.10.1007/s10528-017-9827-429143895Open DOISearch in Google Scholar

Tong Y, Lin Y, Zhang Y, Yang J, Zhang Y, Liu H, Zhang B. Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis. BMC Med Genet 10, 15, 2009.10.1186/1471-2350-10-15265347619228405Search in Google Scholar

Travers ME, McCarthy MI. Type 2 diabetes and obesity: genomics and the clinic. Hum Genet 130, 41–58, 2011.10.1007/s00439-011-1023-821647602Search in Google Scholar

Turki A, Al-Zaben GS, Mtiraoui N, Marmmuoch H, Mahjoub T, Almawi WY. Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Tunisian Arab subjects. Gene 513, 244–248, 2013.10.1016/j.gene.2012.10.08623142382Search in Google Scholar

Wang J, Zhang J, Li L, Wang Y, Wang Q, Zhai Y, You H, Hu D. Association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus: a meta-analysis. Brazilian J Med Biol Res 46, 382–393, 2013.10.1590/1414-431X20132677Search in Google Scholar

Weedon MN. The importance of TCF7L2. Diabet Med 24, 1062–1066, 2007.10.1111/j.1464-5491.2007.02258.x17888129Search in Google Scholar

Xavier HT, Izar MC, Faria Neto JR, Assad MH, Rocha VZ, Sposito AC, Fonseca FA, Santos JE dos, Santos RD, Bertolami MC, Faludi AA, Martinez TLR, Diament J, Guimaraes A, Forti NA, Moriguchi E, Chagas ACP, Coelho OR, Ramires JAF. V Diretriz Brasileira de Dislipidemias e Prevencao da Aterosclerose. Arq Bras Cardiol 101, 1–22, 2013.10.5935/abc.2013S01024217493Search in Google Scholar