c-Fos expression in the hypothalamic paraventricular nucleus after a single treatment with a typical haloperidol and nine atypical antipsychotics: a pilot study

Alexander K, Nikodemova M, Kucerova J, Strbak V. Colchicine treatment differently affects releasable thyrotropinreleasing hormone (TRH) pools in the hypothalamic paraventricular nucleus (PVN) and the median eminence (ME). Cell Mol Neurobiol 25, 681–695, 2005.10.1007/s10571-005-4008-0Open DOISearch in Google Scholar

Basta-Kaim A, Budziszewska B, Jaworska-Feil L, Tetich M, Kubera M, Leskiewicz M, Otczyk M, Lason W. Antipsychotic drugs inhibit the human corticotropin-releasing-hormone gene promoter activity in neuro-2A cellsan involvement of protein kinases. Neuropsychopharmacology 31, 853–865, 2006.10.1038/sj.npp.1300911Open DOISearch in Google Scholar

Beaulieu J, Drolet G, Chanpagne D. Enkephalin innervation of the paraventricular nucleus of the hypothalamus: Distribution of fibers and origins of input. J Chem Neuroanat 10, 79–92, 1996.10.1016/0891-0618(95)00105-0Search in Google Scholar

Blake NG, Johnson MR, Eckland DJA, Foster OJF, Lightman SL. Effect of food deprivation and altered thyroid status on the hypothalamic-pituitary-thyroid axis in the rat. J Endocrinol 133, 183–188, 1992.10.1677/joe.0.1330183Search in Google Scholar

Ceccatelli S, Eriksson M, Hokfelt T. Distribution and coexistence of corticotropin-releasing factor-, neurotensin-, enkephalin-, cholecystokinin-, galanin- and vasoactive intestinal polypeptide/peptide histidine isoleucine-like peptides in the parvocellular part of the paraventricular nucleus. Neuroendocrinology 49, 309–323, 1989.10.1159/000125133Search in Google Scholar

Ceccatelli S, Cortes R, Hokfelt T. Effect of reserpine and colchicine on neuropeptide mRNA levels in the rat hypothalamic paraventricular nucleus. Brain Res Mol Brain Res 9, 57–69, 1991.10.1016/0169-328X(91)90130-PSearch in Google Scholar

Dalcik H, Phelps CJ. Median eminence-afferent vasoactive intestinal peptide (VIP) neurons in the hypothalamus: localization by simultaneous tract tracing and immunocytochemistry. Peptides 14, 1059–1066, 1993.10.1016/0196-9781(93)90087-WOpen DOISearch in Google Scholar

Fujimura M, Hashimoto K, Yamagami K. The effect of the antipsychotic drug mosapramine on the expression of Fos protein in the rat brain: comparison with haloperidol, clozapine and risperidone. Life Sci 67, 2865–2872, 2000.10.1016/S0024-3205(00)00872-9Search in Google Scholar

Hallbeck M. Dynorphin mRNA-expressing neurons in the rat paraventricular hypothalamic nucleus project to the spinal cord. Neurosci Lett 285, 161–164 2000.10.1016/S0304-3940(00)01093-4Search in Google Scholar

Hallbeck M, Larhammar D, Blomqvist A. Neuropeptide expression in rat paraventricular hypothalamic neurons that project to the spinal cord. J Comp Neurol 433, 222–238, 2001.10.1002/cne.113711283961Search in Google Scholar

He M, Deng C, Huang X. The role of hypothalamic H1 receptor antagonism in antipsychotic-induced weight gain. CNS Drugs 27, 423–434, 2013.10.1007/s40263-013-0062-1Open DOISearch in Google Scholar

Herman JP, Figueiredo H, Mueller NK, Ulrich-Lai Y, Ostrander MM, Choi DC, Cullinan WE. Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front Neuroendocrinol 24, 151–180, 2003.10.1016/j.yfrne.2003.07.001Search in Google Scholar

Herman JP, Flak J, Jankord R. Chronic stress plasticity in the hypothalamic paraventricular nucleus. Prog Brain Res 170, 353–364 2008.10.1016/S0079-6123(08)00429-9Search in Google Scholar

Hill JW. PVN pathways controlling energy homeostasis. Indian J Endocrinol Metab 16, S627–S636, 2012.10.4103/2230-8210.105581Search in Google Scholar

Hou-Yu A, Lamme AT, Zimmerman EA, Silverman AJ. Comparative distribution of vasopressin and oxytocin neurons in the rat brain using a double-label procedure. Neuroendocrinology 44, 235–246, 1986.10.1159/000124651Open DOISearch in Google Scholar

Ishikawa K, Taniguchi Y, Kurosumi K, Suzuki M, Shinoda M. Immunohistochemical identification of somatostatincontaining neurons projecting to the median eminence of the rat. Endocrinology 121, 94–97, 1987.10.1210/endo-121-1-94Open DOISearch in Google Scholar

Jennings CA, Cluderay JE, Gartlon J, Cilia J, Lloyd A, Jones DN, Southam E. The effects of ziprasidone on regional c-Fos expression in the rat forebrain. Psychopharmacology (Berl) 184, 13–20, 2006.10.1007/s00213-005-0222-1Search in Google Scholar

Kiss JZ. Dynamism of chemoarchitecture in the hypothalamic paraventricular nucleus. Brain Res Bull 20, 699–708, 1988.10.1016/0361-9230(88)90080-9Open DOISearch in Google Scholar

Kiss A, Pirnik Z, Bundzikova J, Mikkelsen JD. Different antipsychotics elicit different effects on magnocellular oxytocinergic and vasopressinergic neurons as revealed by Fos immunohistochemistry. J Neurosci Res 88, 677–685, 2010.10.1002/jnr.2222619774673Search in Google Scholar

Lennard DE, Eckert WA, Merchenthaler I. Corticotropin-releasing hormone neurons in the paraventricular nucleus project to the external zone of the median eminence: a study combining retrograde labeling with immunocytochemistry. J Neuroendocrinol 5, 175–181, 1993.10.1111/j.1365-2826.1993.tb00378.x8485552Open DOISearch in Google Scholar

Merchenthaler I, Setalo G, Csontos Cs, Petrusz P, Flerko B, Vilar AN. Hormone- and somatostatin-containing neurons projecting to the median eminence of the rat. Endocrinology 125, 2812–2821, 1989.10.1210/endo-125-6-28122479526Search in Google Scholar

Merchenthaler I. Enkephalin-immunoreactive neurons in the parvicellular subdivisions of the paraventricular nucleus project to the external zone of the median eminence. JCN 326, 112–120, 1992.10.1002/cne.9032601101479064Search in Google Scholar

Merchenthaler I, Liposits Z. Mapping of thyrotropin-releasing hormone (TRH) neuronal systems of rat forebrain projecting to the median eminence and the OVLT. Immunocytochemistry combined with retrograde labeling at the light and electron microscopic levels. Acta Biol Hung 45, 361–174, 1994.Search in Google Scholar

Palkovits M, Rokaeus A, Antony FA, Kiss A. Galanin in the hypothalamo-hypophyseal system. Neuroendocrinology 46, 417–423, 1987.10.1159/0001248552448698Open DOISearch in Google Scholar

Park JI, Zhao T, Huang GB, Sui ZY, Li CR, Han EH, Chung YC. Effects of aripiprazole and haloperidol on Fos-like immunoreactivity in the prefrontal cortex and amygdala. Clin Psychopharmacol Neurosci 9, 36–43, 2011a.10.9758/cpn.2011.9.1.36356865323431025Search in Google Scholar

Park SW, Choi SM, Lee JG, Lee CH, Lee SJ, Kim NR, Kim YH. Differential effects of ziprasidone and haloperidol on immobilization-stress-induced CRF mRNA expression in the hypothalamic paraventricular nucleus of rats. Neuropsychobiology 63, 29–34, 2011b.10.1159/00032228821063130Open DOISearch in Google Scholar

Paxinos G, Watson C. The Rat Brain in Stereotaxic coordinates, compact 6th ed. Academic Press, Sydney, 2007.Search in Google Scholar

Pezarro Schimmel LN, Banasikowski TJ, Hawken ER, Dumont EC, Beninger RJ. Brain regions associated with inverse incentive learning: c-Fos immunohistochemistry after haloperidol sensitization on the bar test in rats. Behav Brain Res 293, 81–88, 2015.10.1016/j.bbr.2015.06.04126190766Search in Google Scholar

Rajkumar R, See LK, Dawe GS. Acute antipsychotic treatments induce distinct c-Fos expression patterns in appetiterelated neuronal structures of the rat brain. Brain Res 1508, 34–43, 2013.10.1016/j.brainres.2013.02.05023499563Search in Google Scholar

Ranson RN, Motawei K, Pyner S, Coote JH. The paraventricular nucleus of the hypothalamus sends efferents to the spinal cord of the rat that closely appose sympathetic preganglionic neurones projecting to the stellate ganglion. Exp Brain Res 120, 164–172, 1998.10.1007/s0022100503909629958Search in Google Scholar

Sawchenko PE, Swanson LW, Vale WW. Corticotropin-releasing factor: co-expression within distinct subsets of oxytocin-, vasopressin-, and neurotensin-immunoreactive neurons in the hypothalamus of the male rat. J Neurosci 4, 1118–1129, 1984.10.1523/JNEUROSCI.04-04-01118.1984Open DOISearch in Google Scholar

Sawchenko PE, Swanson LW. Localization, colocalization, and plasticity of corticotropin-releasing factor immunoreactivity in rat brain. Fed Proc 44, 221–227, 1985.Search in Google Scholar

Segerson TP, Hoefler H, Childers H, Wolfe HJ, Wu P, Jackson IM, Lechan RM. Localization of thyrotropin-releasing hormone prohormone messenger ribonucleic acid in rat brain in situ hybridization. Endocrinology 121, 98–107, 1987.10.1210/endo-121-1-983109882Open DOISearch in Google Scholar

Semba J, Sakai M, Miyoshi R, Mataga N, Fukamauchi F, Kito S. Differential expression of c-fos mRNA in rat prefron tal cortex, striatum, N. accumbens and lateral septum after typical and atypical antipsychotics: an in situ hybridization study. Neurochem Int 29, 435–442, 1996.10.1016/0197-0186(95)00156-5Open DOISearch in Google Scholar

Silverman AJ, Hou-Yu A, Chen WP. Corticotropin-releasing factor synapses within the paraventricular nucleus of the hypothalamus. Neuroendocrinology 49, 291–299, 1989.10.1159/000125131Search in Google Scholar

Swanson LW, Kuypers HGJM. The paraventricular nucleus of the hypothalamus: Cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double-labeling methods. J Comp Neurol 194, 555–570, 1980.10.1002/cne.901940306Search in Google Scholar

Swanson LW, Sawchenko PE. Paraventricular nucleus: a site for the integration of neuroendocrine and autonomic mechanisms. Neuroendocrinology 31, 410–417, 1980.10.1159/000123111Open DOISearch in Google Scholar

Swanson LW, Sawchenko PE. Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Annu Rev Neurosci 6, 269–324, 1983.10.1146/annurev.ne.06.030183.001413Open DOISearch in Google Scholar

Swanson LW, Sawchenko PE, Rivier J, Vale WW. Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinology 36, 165–186, 1983.10.1159/000123454Open DOISearch in Google Scholar

Swanson LW, Sawchenko PE, Lind RW. Regulation of multiple peptides in CRF parvocellular neurosecretory neurons: implications for the stress response. Prog Brain Res 68,169–190, 1986.10.1016/S0079-6123(08)60238-1Open DOISearch in Google Scholar

Toni R, Jackson IM, Lechan RM. Neuropeptide-Y-immunoreactive innervation of thyrotropin-releasing hormonesynthesizing neurons in the rat hypothalamic paraventricular nucleus. Endocrinology 126, 2444–2453, 1990.10.1210/endo-126-5-2444Search in Google Scholar

Tringali G, Lisi L, De Simone ML, Aubry JM, Preziosi P, Pozzoli G, Navarra P. Effects of olanzapine and quetiapine on corticotropin-releasing hormone release in the rat brain. Prog Neuropsychopharmacol Biol Psychiatry 33, 1017–1021, 2009.10.1016/j.pnpbp.2009.05.012Open DOISearch in Google Scholar

Wan W, Ennulat DJ, Cohen BM. Acute administration of typical and atypical antipsychotic drugs induces distinctive patterns of Fos expression in the rat forebrain. Brain Res 688, 95–104, 1995.10.1016/0006-8993(95)00544-ZSearch in Google Scholar

Zhao C, Li M. Neuroanatomical substrates of the disruptive effect of olanzapine on rat maternal behavior as revealed by c-Fos immunoreactivity. Pharmacol Biochem Behav 103, 174–180, 2012.10.1016/j.pbb.2012.08.021349480222960130Search in Google Scholar