<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Metabolic syndrome (MetS) and ulcerative colitis (UC) are widespread health conditions characterized by chronic, low-grade inflammation. Galectin-1 (Gal-1), an immunomodulatory peptide mainly secreted from adipose tissue, could potentially play a crucial role in mitigating these conditions. This cross-sectional study explores the involvement of Gal-1 in MetS and UC within a cohort of 75 patients, newly diagnosed with UC. The MetS subgroup displayed increased fecal Gal-1 levels compared to those without MetS. Furthermore, Gal-1 showed predominance over pro-inflammatory cytokines, including TNF-α, IL-6, and IL-17, in these subjects. These findings emphasize the potential involvement of Gal-1 in the pathophysiology of UC and MetS, presenting it as a promising diagnostic biomarker and therapeutic target for these conditions.</p>
</abstract>

Metabolic syndrome (MetS) and ulcerative colitis (UC) are widespread health conditions characterized by chronic, low-grade inflammation. Galectin-1 (Gal-1), an immunomodulatory peptide mainly secreted from adipose tissue, could potentially play a crucial role in mitigating these conditions. This cross-sectional study explores the involvement of Gal-1 in MetS and UC within a cohort of 75 patients, newly diagnosed with UC. The MetS subgroup displayed increased fecal Gal-1 levels compared to those without MetS. Furthermore, Gal-1 showed predominance over pro-inflammatory cytokines, including TNF-α, IL-6, and IL-17, in these subjects. These findings emphasize the potential involvement of Gal-1 in the pathophysiology of UC and MetS, presenting it as a promising diagnostic biomarker and therapeutic target for these conditions.

Modulatory Role of Galectin-1 in Ulcerative Colitis with Comorbid Metabolic Syndrome

University of Kragujevac, Faculty of Medical Sciences

Faculty of Medical Sciences, Department of Internal medicine

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Metabolic syndrome (MetS) and ulcerative colitis (UC) are widespread health conditions characterized by chronic, low-grade inflammation. Galectin-1 (Gal-1), an...

Modulatory Role of Galectin-1 in Ulcerative Colitis with Comorbid Metabolic Syndrome

Publié en ligne: 01 août 2023

Pages: -

Reçu: 25 mai 2023

Accepté: 17 juil. 2023

DOI: https://doi.org/10.2478/eabr-2023-0006

Mots clés
Galectin-1, Ulcerative Colitis, Metabolic Syndrome, Inflammation

© 2023 Kemal Corovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Modulatory Role of Galectin-1 in Ulcerative Colitis with Comorbid Metabolic Syndrome

Publié en ligne: 01 août 2023

Pages: -

Reçu: 25 mai 2023

Accepté: 17 juil. 2023

DOI: https://doi.org/10.2478/eabr-2023-0006

Mots clésGalectin-1, Ulcerative Colitis, Metabolic Syndrome, Inflammation

© 2023 Kemal Corovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
Galectin-1, Ulcerative Colitis, Metabolic Syndrome, Inflammation