An Automated Procedure for the Determination of Total Alkaloids in Cigarette Smoke Using On-line Cyanogen Chloride Generation from Low Hazard Starting Materials

An automated procedure is described for the determination of alkaloids in cigarette smoke using low toxicity reagents. Cyanogen chloride is formed on line from potassium thiocyanate and sodium hypochlorite. The procedure is compared with the previously used cyanogen bromide method which also uses Auto Analyser II methodology.