<abstract xmlns="http://www.w3.org/1999/xhtml"> The determination of the mass-balance after smoking of dotriacontane-16,17-14C added to cigarettes is described. The radiolabelled compound was associated exclusively with the particulate phase of Abstract: The determination of the mass-balance after smoking of dotriacontane-16,17-14C added to cigarettes is described. The radiolabelled compound was associated exclusively with the particulate phase of smoke and transferred from the tobacco with a minimum of pyrolysis. Details are given of the construction and operation of the Animal Smoking Apparatus used for exposing rats to cigarette smoke. Dotriacontane-16,17-14C was used to give an indication of the amount of total particulate matter (TPM) inhaled and retained by rats exposed to mainstream smoke. The mean amounts of dotriacontane-16,17-14C deposited in the head, and in the larynx, trachea and lungs of each of 20 animals treated in the apparatus were found to be, with 95 % confidence Iimits, (2.2 ± 1.4) % and (7.0 ± 3.1) % respectively of the mean total dotriacontane-16,17-14C content of mainstream TPM. </abstract>

The determination of the mass-balance after smoking of dotriacontane-16,17-14C added to cigarettes is described. The radiolabelled compound was associated exclusively with the particulate phase of Abstract: The determination of the mass-balance after smoking of dotriacontane-16,17-14C added to cigarettes is described. The radiolabelled compound was associated exclusively with the particulate phase of smoke and transferred from the tobacco with a minimum of pyrolysis. Details are given of the construction and operation of the Animal Smoking Apparatus used for exposing rats to cigarette smoke. Dotriacontane-16,17-14C was used to give an indication of the amount of total particulate matter (TPM) inhaled and retained by rats exposed to mainstream smoke. The mean amounts of dotriacontane-16,17-14C deposited in the head, and in the larynx, trachea and lungs of each of 20 animals treated in the apparatus were found to be, with 95 % confidence Iimits, (2.2 ± 1.4) % and (7.0 ± 3.1) % respectively of the mean total dotriacontane-16,17-14C content of mainstream TPM.

Studies of Cigarette Smoke Transfer Using Radioisotopically Labelled Tobacco Constituents: Part III: The Use of Dotriacontane-16,17-14C as a Marker for the Deposition of Cigarette Smoke in the Respiratory System of ExperimentaI Animals

Tobacco Research Council Laboratories, Harlow Hill, Harrogate, Yorkshire, England

Contributions to Tobacco & Nicotine Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Studies of Cigarette Smoke Transfer Using Radioisotopically Labelled Tobacco Constituents: Part III: The Use of Dotriacontane-16,17-C as a Marker for the Deposition of Cigarette Smoke in the Respiratory System of ExperimentaI Animals

The determination of the mass-balance after smoking of dotriacontane-16,17-14C added to cigarettes is described. The radiolabelled compound was associated...

Studies of Cigarette Smoke Transfer Using Radioisotopically Labelled Tobacco Constituents: Part III: The Use of Dotriacontane-16,17-¹⁴C as a Marker for the Deposition of Cigarette Smoke in the Respiratory System of ExperimentaI Animals

Publié en ligne: 26 juil. 2014

Pages: 148 - 153

Reçu: 09 mai 1973

DOI: https://doi.org/10.2478/cttr-2013-0323

© Beiträge zur Tabakforschung International

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.