<abstract xmlns="http://www.w3.org/1999/xhtml"><p>In order to obtain information about number and origin of compounds which may contribute to the alkylating activity of tobacco smoke condensate identifiable in the methanol extract of the condensate of commerciaI cigarettes by means of 4-(4'-nitrobenzyI)pyridine, spectroscopic as well as thin-layer- and column-chromatographic procedures were used. Two compounds of the water- or methanoI-soluble fraction were separated and proved to be resorbed during inhalation and dissolved in saliva. During the process of conventional condensate treatment, further five less polaric compounds were found to remain in the cyclohexane fraction, whereas the resulting nitromethane fraction contains the carcinogenic activity almost totally. These compounds can also be extracted from unsmoked tobacco. The role they possibly play in respiratory carcinogenesis is discussed on the basis of the results obtained by the present study with regard to carcinogenic constituents of tobacco extracts. </p></abstract>

In order to obtain information about number and origin of compounds which may contribute to the alkylating activity of tobacco smoke condensate identifiable in the methanol extract of the condensate of commerciaI cigarettes by means of 4-(4'-nitrobenzyI)pyridine, spectroscopic as well as thin-layer- and column-chromatographic procedures were used. Two compounds of the water- or methanoI-soluble fraction were separated and proved to be resorbed during inhalation and dissolved in saliva. During the process of conventional condensate treatment, further five less polaric compounds were found to remain in the cyclohexane fraction, whereas the resulting nitromethane fraction contains the carcinogenic activity almost totally. These compounds can also be extracted from unsmoked tobacco. The role they possibly play in respiratory carcinogenesis is discussed on the basis of the results obtained by the present study with regard to carcinogenic constituents of tobacco extracts.

Chromatographic Examinations on the Separation of the Alkylating Fractions of Cigarette Tobacco and Smoke/Chromatographische Untersuchungen zur Auftrennung alkylierender Fraktionen des Cigarettentabaks und des Cigarettenrauches

Institut für Staublungenforschung und Arbeitsmedizin der Universität Münster, Germany

Contributions to Tobacco & Nicotine Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

In order to obtain information about number and origin of compounds which may contribute to the alkylating activity of tobacco smoke condensate identifiable in...

Chromatographic Examinations on the Separation of the Alkylating Fractions of Cigarette Tobacco and Smoke/Chromatographische Untersuchungen zur Auftrennung alkylierender Fraktionen des Cigarettentabaks und des Cigarettenrauches

Publié en ligne: 19 juil. 2014

Pages: 106 - 116

Reçu: 26 août 1971

DOI: https://doi.org/10.2478/cttr-2013-0276

© Beiträge zur Tabakforschung International

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.