<abstract xmlns="http://www.w3.org/1999/xhtml">
<p>The microsomal enzyme system is responsible for the metabolism of pollutants, toxic agents and drugs. With regards to drug metabolism, the activity of the constituent microsomal enzymes results in the reduction of pharmacological and toxicological activity through conversion of hydrophilic (water soluble) compounds to allow urinary excretion. Microsomal enzymes oxidize drugs and steroid hormones in reactions that require adenine nucleotide diphosphate (NADPH). Reversible inhibition reduces enzyme activity through reversible interaction. A covalent bond between the inhibitor and the enzyme can promote the destruction of essential functional groups of the enzyme. Enzyme induction and inhibition are problematic in drug polytherapy. Often the lack of effect of a drug or the side effects that a certain drug exhibits are problems of interaction of drugs with each other in that individually they inhibit or stimulate enzyme activity.</p>
</abstract>

The microsomal enzyme system is responsible for the metabolism of pollutants, toxic agents and drugs. With regards to drug metabolism, the activity of the constituent microsomal enzymes results in the reduction of pharmacological and toxicological activity through conversion of hydrophilic (water soluble) compounds to allow urinary excretion. Microsomal enzymes oxidize drugs and steroid hormones in reactions that require adenine nucleotide diphosphate (NADPH). Reversible inhibition reduces enzyme activity through reversible interaction. A covalent bond between the inhibitor and the enzyme can promote the destruction of essential functional groups of the enzyme. Enzyme induction and inhibition are problematic in drug polytherapy. Often the lack of effect of a drug or the side effects that a certain drug exhibits are problems of interaction of drugs with each other in that individually they inhibit or stimulate enzyme activity.

Main consequences of enzymatic induction and inhibition during the interaction of drugs and the role of CYP3A4, CYP3A45 enzymes

Department of Pharmacy, Faculty of Medicine

Department of Dentistry, Faculty of Medicine

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The microsomal enzyme system is responsible for the metabolism of pollutants, toxic agents and drugs. With regards to drug metabolism, the activity of the...

Main consequences of enzymatic induction and inhibition during the interaction of drugs and the role of CYP3A4, CYP3A45 enzymes

Publié en ligne: 11 avr. 2024

Pages: 1 - 6

Reçu: 12 mai 2023

Accepté: 03 août 2023

DOI: https://doi.org/10.2478/cipms-2024-0001

Mots clés
induction, inhibition, enzymes, drugs, toxicity

© 2024 Arber Dreshaj et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Main consequences of enzymatic induction and inhibition during the interaction of drugs and the role of CYP3A4, CYP3A45 enzymes

Publié en ligne: 11 avr. 2024

Pages: 1 - 6

Reçu: 12 mai 2023

Accepté: 03 août 2023

DOI: https://doi.org/10.2478/cipms-2024-0001

Mots clésinduction, inhibition, enzymes, drugs, toxicity

© 2024 Arber Dreshaj et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
induction, inhibition, enzymes, drugs, toxicity