<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Although vast scientific progress has been made, the current pharmacotherapy of depression is still not fully effective. In adults, depressive disorders are among the most common diseases in industrialized countries, impact upon all aspects of family and working life and significantly disturb social functioning. Moreover, increasingly, they affect children and teenagers.</p>
<p>Depressive disorders have a complex etiology. This includes a number of mechanisms that are not yet fully understood. Therefore, the current review concentrates on bringing to the foreground the many molecular areas involved in occurrence of this disease. The work highlights the notion that depression has a complex pharmacology and inevitably requires the adoption of individual pharmacotherapy. This manuscript concentrates on currently used drugs drawn from diverse therapeutic groups and presents new promising targets for the treatment of depression. This is a particularly important issue due to the continuous lack of effective therapy and the constant search for new drugs and molecular targets for its treatment.</p>
</abstract>

Although vast scientific progress has been made, the current pharmacotherapy of depression is still not fully effective. In adults, depressive disorders are among the most common diseases in industrialized countries, impact upon all aspects of family and working life and significantly disturb social functioning. Moreover, increasingly, they affect children and teenagers.
Depressive disorders have a complex etiology. This includes a number of mechanisms that are not yet fully understood. Therefore, the current review concentrates on bringing to the foreground the many molecular areas involved in occurrence of this disease. The work highlights the notion that depression has a complex pharmacology and inevitably requires the adoption of individual pharmacotherapy. This manuscript concentrates on currently used drugs drawn from diverse therapeutic groups and presents new promising targets for the treatment of depression. This is a particularly important issue due to the continuous lack of effective therapy and the constant search for new drugs and molecular targets for its treatment.

Different molecular targets, one purpose – treatment of depression

Chair and Department of Pharmacology and Pharmacodynamics

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Different molecular targets, one purpose \u2013 treatment of depression"}

Although vast scientific progress has been made, the current pharmacotherapy of depression is still not fully effective. In adults, depressive disorders are...

Different molecular targets, one purpose – treatment of depression

Publié en ligne: 29 janv. 2021

Pages: 177 - 183

Reçu: 12 janv. 2020

Accepté: 04 déc. 2020

DOI: https://doi.org/10.2478/cipms-2020-0036

Mots clés
depression, antidepressants, atypical mechanisms, novel strategies

© 2020 Magdalena Burat et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Different molecular targets, one purpose – treatment of depression

Publié en ligne: 29 janv. 2021

Pages: 177 - 183

Reçu: 12 janv. 2020

Accepté: 04 déc. 2020

DOI: https://doi.org/10.2478/cipms-2020-0036

Mots clésdepression, antidepressants, atypical mechanisms, novel strategies

© 2020 Magdalena Burat et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
depression, antidepressants, atypical mechanisms, novel strategies