GA genotype of the Arg280His polymorphism on the XRCC1 gene: Genetic susceptibility genotype in differentiated thyroid carcinomas?
, , , , , , et | 27 juil. 2021
À propos de cet article
Article Category: Original Article
Publié en ligne: 27 juil. 2021
Pages: 73 - 80
DOI: https://doi.org/10.2478/bjmg-2021-0003
Mots clés
© 2021 Kirnap NG, Tutuncu NB, Yalcin Y, Cebi HPB, Tutuncu T, Nar A, Verdi H, Atac FB, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Figure 1
General characteristics of the differentiated thyroid carcinoma cases, benign thyroid nodule cases and control groups.
| Characteristics | DTC Cases |
BTN Cases |
Controls |
||
|---|---|---|---|---|---|
| Age (years) | 45.44±12.89 | 46.64±13.28 | 45.06±11.25 | 0.647 | 0.960 |
| Gender: | 0.025 | 0.051 | |||
| females | 176 (77.2) | 83 (83.0) | 62 (66.7) | ||
| males | 52 (22.8) | 17 (17.0) | 31 (33.3) | ||
| Body mass index: | <0.001 | 0.056 | |||
| <25 | 130 (57.0) | 43 (43.0) | 65 (69.9) | ||
| ≤25-<30 | 47 (20.6) | 16 (16.0) | 17 (18.3) | ||
| ≥30 | 51 (22.4) | 41 (41.0) | 11 (11.8) | ||
| Family history of thyroid cancer: | 0.001 | 0.005 | |||
| yes | 18 (7.9) | 1 (1.0) | 0 (0.0) | ||
| no | 210 (92.1) | 99 (99.0) | 93 (100.0) | ||
| Histological type: | |||||
| papillary carcinoma | 221 (96.9) | ||||
| follicular carcinoma | 7 (3.1) | ||||
| Hashimoto’s thyroiditis: | 0.013 | 0.690 | |||
| yes | 28 (12.3) | 25 (25.0) | 13 (14.0) | ||
| no | 199 (87.7) | 75 (75.0) | 80 (86.0) | ||
| Smoking status: | 0.201 | 0.817 | |||
| yes | 44 (19.3) | 28 (28.0) | 19 (20.4) | ||
| no | 184 (80.7) | 72 (72.0) | 74 (78.4) | ||
| Thyroid stimulating hormone level: | <0.001 | 0.063 | |||
| <0.35 | 7 (3.1) | 8 (8.0) | 0 (0.0) | ||
| 0.35-4.50 | 215 (94.3) | 66 (66.0) | 93 (100.0) | ||
| >4.50 | 6 (2.6) | 26 (26.0) | 0 (0.0) |
Genotype frequencies for each of the selected XRCC1 polymorphisms in differentiated thyroid carcinoma, benign thyroid nodule and control groups.
| Polymorphisms | DTC Cases |
BTN Cases |
Controls |
|
|---|---|---|---|---|
| Genotype Frequency: Arg280His GG | 5 (2.6)a | 1 (1.0) | 0 (0.0) | 0.04a |
| GA | 141 (61.8)b | 34 (34.0)b | 3 (3.2) | <0.0001b |
| AA | 81 (35.5)c | 65 (65.0) | 90 (96.8)c | <0.001a |
| Allele frequency: | ||||
| A | 305 (67.0) | 162 (81.0) | 183 (98.0) | |
| G | 151 (33.0) | 38 (19.0) | 3 (2.0) | |
| Genotype frequency: Arg194Trp | ||||
| CC | 223 (97.8) | 97 (97.0) | 83 (89.2) | 0.001a |
| CT | 5 (2.2)a | 3 (3.0)a | 10 (10.8) | 0.032c |
| Allele frequency: | ||||
| C | 451 (99.0) | 197 (98.0) | 176 (95.0) | |
| T | 5 (1.0) | 3 (2.0) | 10 (5.0) | |
| Genotype frequency: Arg399Gln | ||||
| GG | 106 (46.5) | 52 (52.0) | 33 (35.5) | |
| GA | 100 (43.9) | 33 (33.0) | 48 (51.6) | |
| AA | 22 (9.6) | 15 (15.0) | 12 (12.9) | |
| Allele frequency: | ||||
| G | 311 (68.0) | 138 (69.0) | 114 (61.0) | |
| A | 145 (32.0) | 62 (31.0) | 72 (39.0) |
Genotype frequencies in patients with a family history of thyroid cancer.
| Polymorphisms | DTC Cases |
BTN Cases |
Total |
|
|---|---|---|---|---|
| Arg280His: | 0.004 | |||
| GG | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| GA | 15 (83.3) | 0 (0.0) | 15 (78.9) | |
| AA | 3 (16.7) | 1 (100.0) | 4 (21.1) | |
| Arg194Trp: | 0.346 | |||
| CC | 18 (100.0) | 1 (100.0) | 19 (100.0) | |
| CT | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Aarg399Gln: | 0.704 | |||
| GG | 7 (38.9) | 0 (0.0) | 7 (36.8) | |
| GA | 9 (50.0) | 0 (0.0) | 9 (47.4) | |
| AA | 2 (11.1) | 1 (100.0) | 3 (15.8) |