Genome-Wide Methylation Profiling of Schizophrenia

1. Tsuang MT, Faraone SV, Glatt SJ. Schizophrenia, 3rd ed. New York, NY: Oxford University Press, 2011.Search in Google Scholar

2. Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a metaanalysis of twin studies. Arch Gen Psychiatry. 2003; 60(12): 1187-1192.10.1001/archpsyc.60.12.1187Search in Google Scholar

3. Stilo SA, Murray RM. The epidemiology of schizophrenia: replacing dogma with knowledge. Dialogues Clin Neurosci. 2010; 12(3): 305-315.10.31887/DCNS.2010.12.3/sstiloSearch in Google Scholar

4. van Os J, Kapur S. Schizophrenia. Lancet. 2009; 374(9690): 635-645.10.1016/S0140-6736(09)60995-8Search in Google Scholar

5. Turck CW, Maccarrone G, Sayan-Ayata E, Jacob AM, Ditzen C, Kronsbein H, et al. The quest for brain disorder biomarkers. J Med Invest. 2005; 52(Suppl): 231-235.10.2152/jmi.52.23116366504Search in Google Scholar

6. Bird A. Perceptions of epigenetics. Nature. 2007; 447(7143): 396-398.10.1038/nature0591317522671Search in Google Scholar

7. Bird AP. CpG-rich islands and the function of DNA methylation. Nature. 1986; 321(6067): 209-213.10.1038/321209a02423876Search in Google Scholar

8. Bjornsson HT, Sigurdsson MI, Fallin MD, Irizarry RA, Aspelund T, Cui H, et al. Intra-individual change over time in DNA methylation with familial clustering. JAMA. 2008; 299(24): 2877-2883.10.1001/jama.299.24.2877258189818577732Search in Google Scholar

9. Jones PA. Functions of DNA methylation: Islands, start sites, gene bodies and beyond. Nat Rev Genet. 2012; 13(7): 484-492.10.1038/nrg323022641018Search in Google Scholar

10. Moore LD, Le T, Fan G. DNA Methylation and its basic function. Neuropsychopharmacology. 2013; 38(1): 23-38.10.1038/npp.2012.112352196422781841Search in Google Scholar

11. Rakyan VK, Down TA, Thorne NP, Flicek P, Kulesha E, Graf S, et al. An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs). Genome Res. 2008; 18(9): 1518-1529.10.1101/gr.077479.108252770718577705Search in Google Scholar

12. Connor CM, Akbarian S. DNA methylation changes in schizophrenia and bipolar disorder. Epigenetics. 2008; 3(2): 55-58.10.4161/epi.3.2.593818398310Search in Google Scholar

13. Betcheva ET, Mushiroda T, Takahashi A, Kubo M, Karachanak SK, Zaharieva IT, et al. Casecontrol association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. J Hum Genet. 2009; 54(2): 98-107.10.1038/jhg.2008.1419158809Search in Google Scholar

14. Consortium TIS. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature. 2009; 460(7256): 748-752.10.1038/nature08185391283719571811Search in Google Scholar

15. Kirov G, Pocklington AJ, Holmans P, Ivanov D, Ikeda M, Ruderfer D, et al. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Mol Psychiatry. 2012; 17(2): 142-153.10.1038/mp.2011.154360313422083728Search in Google Scholar

16. Raychaudhuri S, Korn JM, McCarroll SA, Altshuler D, Sklar P, Purcell S, et al. Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function. PLoS Genet. 2010; 6(9): e1001097.10.1371/journal.pgen.1001097293652320838587Search in Google Scholar

17. Zaharieva I, Georgieva L, Nikolov I, Kirov G, Owen MJ, O’Donovan MC, et al. Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping. BMC Psychiatry. 2008; 8: 11.10.1186/1471-244X-8-11226868718298822Search in Google Scholar

18. Weber M, Davies JJ, Wittig D, Oakeley EJ, Haase M, Lam WL, et al. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet. 2005; 37(8): 853-862.10.1038/ng159816007088Search in Google Scholar

19. Jia J, Pekowska A, Jaeger S, Benoukraf T, Ferrier P, Spicuglia S. Assessing the efficiency and significance of Methylated DNA Immunoprecipitation (MeDIP) assays in using in vitro methylated genomic DNA. BMC Res Notes. 2010; 3: 240.10.1186/1756-0500-3-240294966220846371Search in Google Scholar

20. Down TA, Rakyan VK, Turner DJ, Flicek P, Li H, Kulesha E, et al. A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol. 2008; 26(7): 779-785.10.1038/nbt1414264441018612301Search in Google Scholar

21. Liekens AM, De Knijf J, Daelemans W, Goethals B, De Rijk P, Del-Favero J. BioGraph: unsupervised biomedical knowledge discovery via automated hypothesis generation. Genome Biol. 2011; 12(6): R57.10.1186/gb-2011-12-6-r57321884521696594Search in Google Scholar

22. Watanabe M, Kanbara K. GABA and GABA Receptors in the Central Nervous System and Other Organs, vol. 213. San Diego, CA: Academic Press, 2002.10.1016/S0074-7696(02)13011-7Search in Google Scholar

23. Liu J, Morgan M, Hutchison K, Calhoun VD. A study of the influence of sex on genome wide methylation. PLoS One. 2010; 5(4): e10028.10.1371/journal.pone.0010028Search in Google Scholar

24. Canuso CM, Pandina G. Gender and schizophrenia. Psychopharmacol Bull. 2007; 40(4): 178-190.Search in Google Scholar

25. Bullock WM, Cardon K, Bustillo J, Roberts RC, Perrone-Bizzozero NI. Altered expression of genes involved in GABAergic transmission and neuromodulation of granule cell activity in the cerebellum of schizophrenia patients. Am J Psychiatry. 2008; 165(12): 1594-1603.10.1176/appi.ajp.2008.07121845Search in Google Scholar

26. Nishioka M, Bundo M, Koike S, Takizawa R, Kakiuchi C, Araki T, et al. Comprehensive DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia. J Hum Genet. 2013; 58(2): 91-97.10.1038/jhg.2012.140Search in Google Scholar

27. Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F, et al. Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Molec Genet. 2011; 20(24): 4786-4796. 10.1093/hmg/ddr416Search in Google Scholar

28. Nakai T, Kitamura N, Hashimoto T, Kajimoto Y, Nishino N, Mita T, et al. Decreased histamine H1 receptors in the frontal cortex of brains from patients with chronic schizophrenia. Biol Psychiatry. 1991; 30(4): 349-356.10.1016/0006-3223(91)90290-3Search in Google Scholar

29. Lee ST, Ryu S, Kim SR, Kim MJ, Kim S, Kim JW, et al. Association study of 27 annotated genes for clozapine pharmacogenetics: validation of preexisting studies and identification of a new candidate gene, ABCB1, for treatment response. J Clin Psychopharmacol. 2012; 32(4): 441-448.10.1097/JCP.0b013e31825ac35c22722500Search in Google Scholar

30. Vehof J, Risselada AJ, Al Hadithy AF, Burger H, Snieder H, Wilffert B, et al. Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication. Psychopharmacology (Berlin). 2011; 216(2): 257-265.10.1007/s00213-011-2211-x312194621336576Search in Google Scholar

31. Gaughran F, Payne J, Sedgwick PM, Cotter D, Berry M. Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder. Brain Res Bull. 2006; 70(3): 221-227.10.1016/j.brainresbull.2006.04.00816861106Search in Google Scholar

32. Bader V, Tomppo L, Trossbach SV, Bradshaw NJ, Prikulis I, Leliveld SR, et al. Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits. Hum Mol Genet. 2012; 21(20): 4406-4418.10.1093/hmg/dds273352958522798627Search in Google Scholar

33. Bornhauser BC, Olsson PA, Lindholm D. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. J Biol Chem. 2003; 278(37): 35412-35420.10.1074/jbc.M306271200Search in Google Scholar

34. Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution.Gene. 1996; 180(1-2): 157-163.10.1016/S0378-1119(96)00445-3Search in Google Scholar

35. Olsson PA, Korhonen L, Mercer EA, Lindholm D. MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. J Biol Chem. 1999; 274(51): 36288-36292.10.1074/jbc.274.51.3628810593918Search in Google Scholar

36. Soundararajan P, Fawcett JP, Rafuse VF. Guidance of postural motoneurons requires MAPK/ERK signaling downstream of fibroblast growth factor receptor 1. J Neurosci. 2010; 30(19): 6595-6606.10.1523/JNEUROSCI.4932-09.2010663257220463222Search in Google Scholar

37. Yamashita N, Uchida Y, Ohshima T, Hirai S, Nakamura F, Taniguchi M, et al. Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration. J Neurosci. 2006; 26(51): 13357-13362.10.1523/JNEUROSCI.4276-06.2006667499317182786Search in Google Scholar

38. Jarskog LF, Glantz LA, Gilmore JH, Lieberman JA. Apoptotic mechanisms in the pathophysiology of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2005; 29(5): 846-858.10.1016/j.pnpbp.2005.03.01015908096Search in Google Scholar

39. Kerns D, Vong GS, Barley K, Dracheva S, Katsel P, Casaccia P, et al. Gene expression abnormalities and oligodendrocyte deficits in the internal capsule in schizophrenia. Schizophr Res. 2010; 120(1-3): 150-158.10.1016/j.schres.2010.04.01220580881Search in Google Scholar

40. Catts VS, Catts SV, McGrath JJ, Féron F, McLean D, Coulson EJ, et al. Apoptosis and schizophrenia: A pilot study based on dermal fibroblast cell lines. Schizophr Res. 2006; 84(1): 20-28.10.1016/j.schres.2006.03.01616626937Search in Google Scholar

41. Boston-Howes W, Gibb SL, Williams EO, Pasinelli P, Brown RH, Trotti D. Caspase-3 cleaves and inactivates the glutamate transporter EAAT2. J Biol Chem. 2006; 281(20): 14076-14084.10.1074/jbc.M60065320016567804Search in Google Scholar

42. Sari Y, Zhou FC. Prenatal alcohol exposure causes long-term serotonin neuron deficit in mice. Alcohol Clin Exp Res. 2004; 28(6): 941-948.10.1097/01.ALC.0000128228.08472.39Search in Google Scholar

43. Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, et al. Structural basis for the inhibition of Caspase-3 by XIAP. Cell. 2001; 104(5): 791-800.10.1016/S0092-8674(01)00274-4Search in Google Scholar

44. Meynen G, Unmehopa UA, Hofman MA, Swaab DF, Hoogendijk WJ. Hypothalamic oxytocin mRNA expression and melancholic depression. Mol Psychiatry. 2007; 12(2): 118-119.10.1038/sj.mp.400191117252002Search in Google Scholar

45. Kyosseva SV. The role of the extracellular signal- regulated kinase pathway in cerebellar abnormalities in schizophrenia. Cerebellum. 2004; 3(2): 94-99.10.1080/1473422041002916415233576Search in Google Scholar

46. Lin DC, Quevedo C, Brewer NE, Bell A, Testa JR, Grimes ML, et al. APPL1 Associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction. Mol Cell Biol. 2006; 26(23): 8928-8941.10.1128/MCB.00228-06163681517000777Search in Google Scholar

47. Yano H, Ninan I, Zhang H, Milner TA, Arancio O, Chao MV. BDNF-Mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci. 2006; 9(8): 1009-1018. 10.1038/nn173016819522Search in Google Scholar