<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Double balanced translocations are particularly rare and the risk of a fetus with an unbalanced chromosomal anomaly is greater than for single translocation carriers. In this present case, we describe an interesting family history which included three generations. A couple, married for 4 years, was referred to the genetic clinic due to infertility and family chromosome anomalies. A GTG-band chromosome analysis indicated that the male partner’s karyotype was 45,XY, t(3;18)(q11;ptel)t(13;14)(q10;q10). The same double balanced translocation was found in two others family members.</p></abstract>

Double balanced translocations are particularly rare and the risk of a fetus with an unbalanced chromosomal anomaly is greater than for single translocation carriers. In this present case, we describe an interesting family history which included three generations. A couple, married for 4 years, was referred to the genetic clinic due to infertility and family chromosome anomalies. A GTG-band chromosome analysis indicated that the male partner’s karyotype was 45,XY, t(3;18)(q11;ptel)t(13;14)(q10;q10). The same double balanced translocation was found in two others family members.

Double Translocation: An Interesting Family History

Department of Obstetrics and Gynecology, Çanakkale Onsekiz Mart University, Çanakkale,Turkey

Department of Medical Genetics, Çanakkale Onsekiz Mart University, Çanakkale, Turkey

Department of Medical Genetics, Vehbi Koç Vakfı (VKV) American Hospital, Istanbul, Turkey

Department of Biology, Abant Izzet Baysal University, Bolu, Turkey

Balkan Journal of Medical Genetics

{"article-title":"Double Translocation: An Interesting Family History"}

Double balanced translocations are particularly rare and the risk of a fetus with an unbalanced chromosomal anomaly is greater than for single translocation...

Double Translocation: An Interesting Family History

Publié en ligne: 03 oct. 2013

Pages: 77 - 80

DOI: https://doi.org/10.2478/bjmg-2013-0022

This content is open access.