<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The aim of this study was to examine single nucleotide polymorphisms (SNPs) of candidate genes α2-Heremans-Schmid glycoprotein (AHSG, rs4917), Hypocretin (HCRT, rs760282) and Neuropetide Y2 receptor (NPY2R, rs 1047214), which are known to have a potential effect on body mass index (BMI) and other indicators of obesity. A population study was performed in 2007/2008 on 2559 adults (1191 males and 1368 females) from the Czech post-MONICA project. The SNPs were examined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We did not find any significant association between the examined SNPs and BMI across the whole population. A significantly lower triglyceride level was found in the AHSG gene CC homozygotes compared to T allele carriers in the entire population (p = 0.009). In conclusion, we are not able to confirm the hypothesis that polymorphisms within the AHSG, HCRT and NPY2R genes are major genetic determinants of BMI and plasma lipids in the Czech-Slavonic population.</p></abstract>

The aim of this study was to examine single nucleotide polymorphisms (SNPs) of candidate genes α2-Heremans-Schmid glycoprotein (AHSG, rs4917), Hypocretin (HCRT, rs760282) and Neuropetide Y2 receptor (NPY2R, rs 1047214), which are known to have a potential effect on body mass index (BMI) and other indicators of obesity. A population study was performed in 2007/2008 on 2559 adults (1191 males and 1368 females) from the Czech post-MONICA project. The SNPs were examined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We did not find any significant association between the examined SNPs and BMI across the whole population. A significantly lower triglyceride level was found in the AHSG gene CC homozygotes compared to T allele carriers in the entire population (p = 0.009). In conclusion, we are not able to confirm the hypothesis that polymorphisms within the AHSG, HCRT and NPY2R genes are major genetic determinants of BMI and plasma lipids in the Czech-Slavonic population.

Lack of Association Between Variants within the AHSG, HCRT and NPY2R Genes and Anthropometrical Parameters in Czech Post-Monica Study

Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Balkan Journal of Medical Genetics

The aim of this study was to examine single nucleotide polymorphisms (SNPs) of candidate genes α2-Heremans-Schmid glycoprotein (AHSG, rs4917), Hypocretin...

Lack of Association Between Variants within the AHSG, HCRT and NPY2R Genes and Anthropometrical Parameters in Czech Post-Monica Study

Publié en ligne: 03 oct. 2013

Pages: 63 - 68

DOI: https://doi.org/10.2478/bjmg-2013-0019

This content is open access.