<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Synonymous mutations in a protein coding gene lead to a remarkably similar average “collateral” mutation effect size across alternative reading frames (1). Here we quantify the rarity of this feature among possible block structure codes as 0.77%. Then we develop a simple model of evolutionary search with two types of mutation. Across different mutation step sizes and ratios of the two types, the fitness-maximizing region corresponds to using a single average mutation value. The analogous constant average collateral mutation effect observed for the standard genetic code may likewise facilitate evolutionary search in alternative frame sequences.</p>
</abstract>

Synonymous mutations in a protein coding gene lead to a remarkably similar average “collateral” mutation effect size across alternative reading frames (1). Here we quantify the rarity of this feature among possible block structure codes as 0.77%. Then we develop a simple model of evolutionary search with two types of mutation. Across different mutation step sizes and ratios of the two types, the fitness-maximizing region corresponds to using a single average mutation value. The analogous constant average collateral mutation effect observed for the standard genetic code may likewise facilitate evolutionary search in alternative frame sequences.

Highly Similar Average Collateral Effect of Synonymous Mutations Across Alternative Reading Frames: A Potential Role In Evolvability

BioCosmos: New perspectives on the origin and evolution of life

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Synonymous mutations in a protein coding gene lead to a remarkably similar average “collateral” mutation effect size across alternative reading frames (1)....

Highly Similar Average Collateral Effect of Synonymous Mutations Across Alternative Reading Frames: A Potential Role In Evolvability

Publié en ligne: 17 mars 2023

Pages: 1 - 11

DOI: https://doi.org/10.2478/biocosmos-2023-0001

Mots clés
genetic code optimality, evolvability, gene origins

© 2023 Stefan Wichmann et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Highly Similar Average Collateral Effect of Synonymous Mutations Across Alternative Reading Frames: A Potential Role In Evolvability

Publié en ligne: 17 mars 2023

Pages: 1 - 11

DOI: https://doi.org/10.2478/biocosmos-2023-0001

Mots clésgenetic code optimality, evolvability, gene origins

© 2023 Stefan Wichmann et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
genetic code optimality, evolvability, gene origins