<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The current study is aimed at the analgesic evaluation of quinazolinone derivatives. The quinazolinone derivatives 7-chloro-2-methyl-4H-benzo[d][1,3]-oxazin-4-one and 3-amino-7-chloro-2-methyl-quinazolin-4(3H)-one were evaluated pharmacologically for their in vivo analgesic activities by acetic acid induced writhing in mice. The compounds exhibited significant analgesic activity in the range of 74.67 - 83.80% in comparison to control. </p></abstract>

The current study is aimed at the analgesic evaluation of quinazolinone derivatives. The quinazolinone derivatives 7-chloro-2-methyl-4H-benzo[d][1,3]-oxazin-4-one and 3-amino-7-chloro-2-methyl-quinazolin-4(3H)-one were evaluated pharmacologically for their in vivo analgesic activities by acetic acid induced writhing in mice. The compounds exhibited significant analgesic activity in the range of 74.67 - 83.80% in comparison to control.

Analgesic activity of newly synthesized 7-chloro–2–methyl-4H–benzo[d] [1,3]–oxazin–4–one and 3–amino-7-chloro-2–methyl-quinazolin-4(3H)–one

Ovidius University Annals of Chemistry

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The current study is aimed at the analgesic evaluation of quinazolinone derivatives. The quinazolinone derivatives...

Analgesic activity of newly synthesized 7-chloro–2–methyl-4H–benzo[d] [1,3]–oxazin–4–one and 3–amino-7-chloro-2–methyl-quinazolin-4(3H)–one

Publié en ligne: 28 juin 2018

Pages: 25 - 28

Reçu: 10 mars 2018

Accepté: 04 juin 2018

DOI: https://doi.org/10.2478/auoc-2018-0003

Mots clés
3-amino-7-chloro-2-methyl-quinazolin-4(3H)-one, 7-chloro-2-methyl-4H-benzo[d][1,3]-oxazine-4-one, quinazolin-4(3H)-one, analgesic activity

© 2018 Peter O. Osarumwense, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Analgesic activity of newly synthesized 7-chloro–2–methyl-4H–benzo[d] [1,3]–oxazin–4–one and 3–amino-7-chloro-2–methyl-quinazolin-4(3H)–one

Publié en ligne: 28 juin 2018

Pages: 25 - 28

Reçu: 10 mars 2018

Accepté: 04 juin 2018

DOI: https://doi.org/10.2478/auoc-2018-0003

Mots clés3-amino-7-chloro-2-methyl-quinazolin-4(3H)-one, 7-chloro-2-methyl-4H-benzo[d][1,3]-oxazine-4-one, quinazolin-4(3H)-one, analgesic activity

© 2018 Peter O. Osarumwense, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
3-amino-7-chloro-2-methyl-quinazolin-4(3H)-one, 7-chloro-2-methyl-4H-benzo[d][1,3]-oxazine-4-one, quinazolin-4(3H)-one, analgesic activity