<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Tetraclinis articulata (Thuya of Barbary), endemic to North Africa, is used as a traditional medicine for the treatment of many diseases [1]. We investigated the antidiarrhoel properties of the butanol extract of Tetraclinis articulata (<bold>BETA</bold>) in male and female Swiss albino mice to support its traditional use. The antidiarrhoeal activity of the plant extract was evaluated in a model of castor oil-induced diarrhoea model in mice and compared to loperamide (a reference inhibitor of diarrhoea). The effect of (BETA) on gastrointestinal motility was determined by the oral administration of charcoal and Castrol oil-induced intestinal fluid accumulation (enteropooling).The (BETA) showed remarkable antidiarrhoeal activity significantly inhibited gastrointestinal motility and castor oil induced enteropolysis (<bold>68,18%)</bold>, more than to the inhibition achieved in loperamide treated mice (<bold>60,16%).</bold> The second aim of the present study was to evaluate the anti-ulcerative activity of The (BETA), it produced percent protection of control colitis by <bold>77, 40</bold>%, while the standard drug (aspirin) produced <bold>81,39%</bold> protection. We conclude that Tetraclinis articulata extracts are potential sources of new anti-ulcer agents and antidiarrhoeal drugs.</p></abstract>

Tetraclinis articulata (Thuya of Barbary), endemic to North Africa, is used as a traditional medicine for the treatment of many diseases [1]. We investigated the antidiarrhoel properties of the butanol extract of Tetraclinis articulata (BETA) in male and female Swiss albino mice to support its traditional use. The antidiarrhoeal activity of the plant extract was evaluated in a model of castor oil-induced diarrhoea model in mice and compared to loperamide (a reference inhibitor of diarrhoea). The effect of (BETA) on gastrointestinal motility was determined by the oral administration of charcoal and Castrol oil-induced intestinal fluid accumulation (enteropooling).The (BETA) showed remarkable antidiarrhoeal activity significantly inhibited gastrointestinal motility and castor oil induced enteropolysis (68,18%), more than to the inhibition achieved in loperamide treated mice (60,16%). The second aim of the present study was to evaluate the anti-ulcerative activity of The (BETA), it produced percent protection of control colitis by 77, 40%, while the standard drug (aspirin) produced 81,39% protection. We conclude that Tetraclinis articulata extracts are potential sources of new anti-ulcer agents and antidiarrhoeal drugs.

<italic>In-vivo</italic> Antidiarrhoeal and anti-ulcerative activities of the <italic>Tetraclinis articulata</italic> species of the <italic>Cupressaceae</italic> family

Department of Sciences of Matter, Faculty of Natural Sciences and Life

Unit for the Valorization of Natural Resources, Bioactive Molecules and Physico-Chemical and Biological Analyzes, Faculty of Exact Sciences, Department of Chemistry

Faculty of Medicine, Department of Pharmacy

University Salah BOUBNIDER of Constantine 03

Acta Scientifica Naturalis

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

 Antidiarrhoeal and anti-ulcerative activities of the  species of the  family

Tetraclinis articulata (Thuya of Barbary), endemic to North Africa, is used as a traditional medicine for the treatment of many diseases [1]. We investigated...

In-vivo Antidiarrhoeal and anti-ulcerative activities of the Tetraclinis articulata species of the Cupressaceae family

Publié en ligne: 27 mai 2019

Pages: 50 - 53

Reçu: 01 févr. 2019

Accepté: 01 mars 2019

DOI: https://doi.org/10.2478/asn-2019-0007

Mots clés
n-butanol extract, antidiarrhoeal activity, anti-ulcerative activity

© 2019 Zine El Abidine Ababsa et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

In-vivo Antidiarrhoeal and anti-ulcerative activities of the Tetraclinis articulata species of the Cupressaceae family

Publié en ligne: 27 mai 2019

Pages: 50 - 53

Reçu: 01 févr. 2019

Accepté: 01 mars 2019

DOI: https://doi.org/10.2478/asn-2019-0007

Mots clésn-butanol extract, antidiarrhoeal activity, anti-ulcerative activity

© 2019 Zine El Abidine Ababsa et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
n-butanol extract, antidiarrhoeal activity, anti-ulcerative activity