Single nucleotide polymorphisms in odontogenesis-related genes associated with tooth-size discrepancy
, , , , , , et | 27 févr. 2023
Publié en ligne: 27 févr. 2023
Pages: 86 - 95
Reçu: 01 août 2022
Accepté: 01 janv. 2023
© 2023 Caio Luiz Bitencourt Reis et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Figure 1
Patient flow of the study.Characteristics of SNPs.
Genes |
SNPs |
Type of Alteration |
Base Change |
Global MAF* |
Genotyping success rate |
RUNX2 |
rs59983488 |
Upstream Variant |
G > T |
0.15 |
88.7% |
Rs1200425 |
Intron Variant |
G > A |
0.44 |
87.0% |
SMAD6 |
rs3934908 |
Intron Variant |
C > T |
0.41 |
91.9% |
Rs211261 |
Intron Variant |
C > T |
0.19 |
90.3% |
BMP2 |
rs1005464 |
Intron Variant |
G > A |
0.19 |
91.9% |
rs235768 |
Missense Variant |
T > A |
0.32 |
90.3% |
BMP4 |
Rs17563 |
Missense Variant |
A > G |
0.42 |
88.7% |
Allelic and Genotypic distribution between anterior TSD groups and comparison by Fisher Test.
Gene |
SNP |
Comparison Type |
Alleles or Genotypes |
Control (%) |
Control vs. Maxillary tooth-size anterior excess |
Control vs. Mandibular tooth-size anterior excess |
Maxillary (%) |
p-value |
OR |
95% CI |
Mandibular (%) |
p-value |
Odds Ratio |
95% Confidence Interval |
|
|
|
AA |
2 (6.5) |
1 (12.5) |
0.536 |
1.91 |
0.11–18.28 |
0 (0.0) |
>0.999 |
- |
- |
|
rs235768 |
Allelic |
T |
47 (75.8) |
11 (68.7) |
|
|
Ref. |
26 (72.2) |
|
|
Ref. |
|
|
|
A |
15 (24.2) |
5 (31.3) |
0.539 |
1.42 |
0.46–4.88 |
10 (27.8) |
0.810 |
1.20 |
0.44–2.92 |
|
|
Genotypic |
TT |
16 (51.6) |
4 (50.0) |
|
|
Ref. |
9 (50.0) |
|
|
Ref. |
|
|
|
TA |
15 (48.4) |
3 (37.5) |
>0.999 |
0.80 |
0.17–3.41 |
8 (44.4) |
>0.999 |
0.94 |
0.30–2.84 |
|
|
|
AA |
0 (0.0) |
1 (12.5) |
0.23 |
- |
- |
1 (5.6) |
0.384 |
- |
- |
BMP4 |
rs17563 |
Allelic |
A |
39 (62.9) |
9 (64.3) |
|
|
Ref. |
21 (61.8) |
|
|
Ref. |
|
|
|
G |
23 (37.1) |
5 (35.7) |
>0.999 |
0.94 |
0.31–3.11 |
13 (38.2) |
>0.999 |
1.05 |
0.46–2.47 |
|
|
Genotypic |
AA |
13 (41.9) |
2 (28.6) |
|
|
Ref. |
7(41.2) |
|
|
Ref. |
|
|
|
AG |
13 (41.9) |
5 (71.4) |
0.413 |
2.50 |
0.37–13.97 |
7(41.2) |
>0.999 |
1.00 |
0.25–3.96 |
|
|
|
GG |
5 (16.1) |
0 (0.0) |
>0.999 |
- |
- |
3 (17.6) |
>0.999 |
1.11 |
0.23–5.39 |
Allelic and Genotypic distribution between overall TSD groups and comparison by Fisher Test.
|
|
|
|
|
Control vs. Maxillary tooth-size overall excess |
Control vs. Mandibular tooth-size overall excess |
Gene |
SNP |
Model |
Alleles or Genotypes |
Control (%) |
Maxillary (%) |
p-value |
Odds ratio |
95% Confidence Interval |
Mandibular (%) |
p-value |
Odds Ratio |
95% Confidence Interval |
|
|
|
AA |
3 (9.7) |
0 (0.0) |
>0.999 |
- |
- |
0 (0.0) |
0.268 |
- |
- |
|
rs235768 |
Allelic |
T |
48 (75.0) |
8 (80.0) |
|
|
Ref. |
28 (70.0) |
|
|
Ref. |
|
|
|
A |
16 (25.0) |
2 (20.0) |
>0.999 |
0.75 |
0.14–3.84 |
12 (30.0) |
0.651 |
1.28 |
0.55–3.18 |
|
|
Genotypic |
TT |
17 (53.1) |
3 (60.0) |
|
|
Ref. |
9 (45.0) |
|
|
Ref. |
|
|
|
TA |
14 (43.8) |
2 (40.0) |
>0.999 |
0.80 |
0.13–4.44 |
10 (50.0) |
0.771 |
1.34 |
0.40–3.89 |
|
|
|
AA |
1 (3.1) |
0 (0.0) |
>0.999 |
- |
- |
1 (5.0) |
>0.999 |
1.88 |
0.09–37.71 |
BMP4 |
rs17563 |
Allelic |
A |
34 (55.7) |
6 (60.0) |
|
|
Ref. |
29 (72.5) |
|
|
Ref. |
|
|
|
G |
26 (43.3) |
4 (40.0) |
>0.999 |
|
|
11 (27.5) |
0.139 |
0.49 |
0.21–1.13 |
|
|
Genotypic |
AA |
10 (33.3) |
2 (40.0) |
|
|
Ref. |
10 (50.0) |
|
|
Ref. |
|
|
|
AG |
14 (46.7) |
2 (40.0) |
>0.999 |
0.71 |
0.10–5.21 |
9 (45.0) |
0.547 |
0.64 |
0.19–1.99 |
|
|
|
GG |
6 (20.0) |
1 (20.0) |
>0.999 |
0.83 |
0.05–8.47 |
1 (5.0) |
0.183 |
0.16 |
0.01–1.64 |