<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Recently, inflammation has been recognised as an important co-requisite to orthodontic tooth movement. When such a reaction is initiated, the process of up-regulation of certain adhesion molecules may occur, resulting in the extravasation of leukocytes. This may stimulate progenitor/precursor pathways and signals that regulate the biological responses resulting in tooth movement. We propose that up-regulation of leukocyte adhesion molecules occurs in response to orthodontic forces, resulting in circulating monocyte attraction, extravasation and differentiation into osteoclasts, which are responsible for bone resorption that results in orthodontic tooth movement. To investigate this hypothesis, it is necessary to determine whether periodontal ligament (PDL) endothelium responds to inflammatory stimuli as other organs do. We studied the normal distribution of endothelial adhesion molecule ICAM-1 within PDL vessels, and then the following exposure to an inflammatory endotoxin. The rat PDL blood vessels expressed ICAM-1 in response to the inflammatory stimulus, similar to other organs, suggesting that the inflammatory responses are similar. Whether and where in the PDL microvascular bed orthodontic forces cause up-regulation of ICAM-1 needs to be established.</p>
</abstract>

Recently, inflammation has been recognised as an important co-requisite to orthodontic tooth movement. When such a reaction is initiated, the process of up-regulation of certain adhesion molecules may occur, resulting in the extravasation of leukocytes. This may stimulate progenitor/precursor pathways and signals that regulate the biological responses resulting in tooth movement. We propose that up-regulation of leukocyte adhesion molecules occurs in response to orthodontic forces, resulting in circulating monocyte attraction, extravasation and differentiation into osteoclasts, which are responsible for bone resorption that results in orthodontic tooth movement. To investigate this hypothesis, it is necessary to determine whether periodontal ligament (PDL) endothelium responds to inflammatory stimuli as other organs do. We studied the normal distribution of endothelial adhesion molecule ICAM-1 within PDL vessels, and then the following exposure to an inflammatory endotoxin. The rat PDL blood vessels expressed ICAM-1 in response to the inflammatory stimulus, similar to other organs, suggesting that the inflammatory responses are similar. Whether and where in the PDL microvascular bed orthodontic forces cause up-regulation of ICAM-1 needs to be established.

The immunohistochemical response of the rat periodontal ligament endothelium to an inflammatory stimulus

Senior Lecturer, Microcirculation Laboratory

School of Medicine, Flinders University of South Australia

Australasian Orthodontic Journal

This work is licensed under the Creative Commons Attribution 4.0 International License.

Recently, inflammation has been recognised as an important co-requisite to orthodontic tooth movement. When such a reaction is initiated, the process of...

The immunohistochemical response of the rat periodontal ligament endothelium to an inflammatory stimulus

Publié en ligne: 13 déc. 2023

Pages: 61 - 68

Reçu: 01 sept. 1999

Accepté: 01 avr. 2000

DOI: https://doi.org/10.2478/aoj-2000-0009

Mots clés
adhesion molecules, inflammation, periodontal ligament, tooth movement

© 2000 Andrew Toms et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

The immunohistochemical response of the rat periodontal ligament endothelium to an inflammatory stimulus

Publié en ligne: 13 déc. 2023

Pages: 61 - 68

Reçu: 01 sept. 1999

Accepté: 01 avr. 2000

DOI: https://doi.org/10.2478/aoj-2000-0009

Mots clésadhesion molecules, inflammation, periodontal ligament, tooth movement

© 2000 Andrew Toms et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Mots clés
adhesion molecules, inflammation, periodontal ligament, tooth movement