<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Bisphenol A (BPA ) is a substance commonly used in the production of plastics. Previous studies have described that it shows multidirectional harmful effects on the living organism. It is known that BPA causes liver damage, but knowledge about the roles of intrahepatic nerves in these mechanisms is extremely scanty. On the other hand, the exact roles of some neuronal substances in the nervous structures located in the liver still remain unknown. One of such substance, which is allocated a role in the stimulation of cell survival is neuregulin 1 (NRG-1). The aim of the present study was to investigate the distribution of NRG-1-like immunoreactive (NRG-1-LI) nerves in the liver in physiological conditions and under the influence of various doses of BPA using routine double immunofluorescence staining. The results (for the first time) show the presence of NRG-1 in the intrahepatic nerves, and co-localization of NGR-1 with neuronal isoform of nitric oxide synthase (nNOS) and vasoactive intestinal polypeptide (VIP). Moreover, it has been observed that high doses of BPA increase the density of NRG-1-LI intrahepatic nerves and the degree of co-localization of NRG-1 with VIP. These observations suggest that NRG-1 located in intrahepatic nerves may play functions in processes connected with liver damage and/or regeneration under the impact of BPA.</p></abstract>

Bisphenol A (BPA ) is a substance commonly used in the production of plastics. Previous studies have described that it shows multidirectional harmful effects on the living organism. It is known that BPA causes liver damage, but knowledge about the roles of intrahepatic nerves in these mechanisms is extremely scanty. On the other hand, the exact roles of some neuronal substances in the nervous structures located in the liver still remain unknown. One of such substance, which is allocated a role in the stimulation of cell survival is neuregulin 1 (NRG-1). The aim of the present study was to investigate the distribution of NRG-1-like immunoreactive (NRG-1-LI) nerves in the liver in physiological conditions and under the influence of various doses of BPA using routine double immunofluorescence staining. The results (for the first time) show the presence of NRG-1 in the intrahepatic nerves, and co-localization of NGR-1 with neuronal isoform of nitric oxide synthase (nNOS) and vasoactive intestinal polypeptide (VIP). Moreover, it has been observed that high doses of BPA increase the density of NRG-1-LI intrahepatic nerves and the degree of co-localization of NRG-1 with VIP. These observations suggest that NRG-1 located in intrahepatic nerves may play functions in processes connected with liver damage and/or regeneration under the impact of BPA.

Neuregulin 1 (NRG-1) as a Neuronal Active Substance in the Porcine Intrahepatic Nerve Fibers in Physiological Conditions and Under the Influence of Bisphenol a (BPA )

Department of Internal Diseases with Clinic, Faculty of Veterinary Medicine

Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences

Department of Clinical Physiology, Faculty of Veterinary Medicine

Annals of Animal Science

This work is licensed under the Creative Commons Attribution 4.0 International License.

Bisphenol A (BPA ) is a substance commonly used in the production of plastics. Previous studies have described that it shows multidirectional harmful effects...

Neuregulin 1 (NRG-1) as a Neuronal Active Substance in the Porcine Intrahepatic Nerve Fibers in Physiological Conditions and Under the Influence of Bisphenol a (BPA )

Publié en ligne: 07 nov. 2020

Pages: 1339 - 1350

Reçu: 14 août 2019

Accepté: 19 mars 2020

DOI: https://doi.org/10.2478/aoas-2020-0038

Mots clés
bisphenol A, liver, neuregulin, VIP, nNOS, porcine

© 2020 Liliana Rytel et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Neuregulin 1 (NRG-1) as a Neuronal Active Substance in the Porcine Intrahepatic Nerve Fibers in Physiological Conditions and Under the Influence of Bisphenol a (BPA )

Publié en ligne: 07 nov. 2020

Pages: 1339 - 1350

Reçu: 14 août 2019

Accepté: 19 mars 2020

DOI: https://doi.org/10.2478/aoas-2020-0038

Mots clésbisphenol A, liver, neuregulin, VIP, nNOS, porcine

© 2020 Liliana Rytel et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Mots clés
bisphenol A, liver, neuregulin, VIP, nNOS, porcine