<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Septic cardiomyopathy remains a difficult medical problem to manage in critically ill patients. With all currently available therapeutic options, the mortality rate in these patients remains high. Our study included 29 patients diagnosed clinically with sepsis. A control group was used to compare the results. In all patients, p53 expression was assessed in cardiac tissue obtained from these patients and a statistical correlation was made with clinical data. The different expression rates of p53 do not correlate with patient’s age, having appropriate means in years, but with an increasing tendency with increasing expression (p=0.2110). The pulmonary infections are responsible for the majority of the septic state in the study group (over 55%). The difference between the infection sites is statistically significant (p&lt;0.0001).</p>
</abstract>

Septic cardiomyopathy remains a difficult medical problem to manage in critically ill patients. With all currently available therapeutic options, the mortality rate in these patients remains high. Our study included 29 patients diagnosed clinically with sepsis. A control group was used to compare the results. In all patients, p53 expression was assessed in cardiac tissue obtained from these patients and a statistical correlation was made with clinical data. The different expression rates of p53 do not correlate with patient’s age, having appropriate means in years, but with an increasing tendency with increasing expression (p=0.2110). The pulmonary infections are responsible for the majority of the septic state in the study group (over 55%). The difference between the infection sites is statistically significant (p<0.0001).

The Role of P53 in Sepsis-Induced Cardiomyopathy

Acta Medica Transilvanica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"The Role of P53 in Sepsis-Induced Cardiomyopathy"}

Septic cardiomyopathy remains a difficult medical problem to manage in critically ill patients. With all currently available therapeutic options, the mortality...

The Role of P53 in Sepsis-Induced Cardiomyopathy

Publié en ligne: 03 nov. 2021

Pages: 45 - 47

Reçu: 25 mai 2021

Accepté: 30 juil. 2021

DOI: https://doi.org/10.2478/amtsb-2021-0049

Mots clés
p53, cardiomyopathy, sepsis, IHC

© 2021 Peter Michael Reil et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Role of P53 in Sepsis-Induced Cardiomyopathy

Publié en ligne: 03 nov. 2021

Pages: 45 - 47

Reçu: 25 mai 2021

Accepté: 30 juil. 2021

DOI: https://doi.org/10.2478/amtsb-2021-0049

Mots clésp53, cardiomyopathy, sepsis, IHC

© 2021 Peter Michael Reil et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
p53, cardiomyopathy, sepsis, IHC