<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Platelet indices have been linked to the severity and prognosis of coronary artery disease, but a very small number of studies assessed them under dual antiplatelet therapy after percutaneous coronary intervention (PCI). The aim of this study was to evaluate changes in mean platelet volume (MPV), platelet distribution width (PDW) and platelet-large cell ratio (P-LCR) in these patients. A number of 437 patients with stable coronary artery disease, 131 patients with non ST segment elevation acute coronary syndrome and 151 patients with ST segment elevation myocardial infarction were included in the study. There was no difference between the three groups regarding platelet indices prior to PCI. Follow-up data was available for 181 patients, at a mean follow-up time of 69 (46-98) days. MPV, PDW and PLC-R were similar to those prior to PCI in all three groups. Regarding the P2Y12 inhibitor, clopidogrel or ticagrelor, there was no difference at follow-up between platelet indices irrespective of the indication for PCI.</p></abstract>

Platelet indices have been linked to the severity and prognosis of coronary artery disease, but a very small number of studies assessed them under dual antiplatelet therapy after percutaneous coronary intervention (PCI). The aim of this study was to evaluate changes in mean platelet volume (MPV), platelet distribution width (PDW) and platelet-large cell ratio (P-LCR) in these patients. A number of 437 patients with stable coronary artery disease, 131 patients with non ST segment elevation acute coronary syndrome and 151 patients with ST segment elevation myocardial infarction were included in the study. There was no difference between the three groups regarding platelet indices prior to PCI. Follow-up data was available for 181 patients, at a mean follow-up time of 69 (46-98) days. MPV, PDW and PLC-R were similar to those prior to PCI in all three groups. Regarding the P2Y12 inhibitor, clopidogrel or ticagrelor, there was no difference at follow-up between platelet indices irrespective of the indication for PCI.

Clopidogrel and Ticagrelor Do Not Influence Platelet Indices After Percutaneous Coronary Intervention

“George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu-Mureş

Acta Medica Transilvanica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Platelet indices have been linked to the severity and prognosis of coronary artery disease, but a very small number of studies assessed them under dual...

Clopidogrel and Ticagrelor Do Not Influence Platelet Indices After Percutaneous Coronary Intervention

Publié en ligne: 29 janv. 2021

Pages: 35 - 37

Reçu: 27 juin 2020

Accepté: 02 déc. 2020

DOI: https://doi.org/10.2478/amtsb-2020-0067

Mots clés
percutaneous coronary intervention, platelets, mean platelet volume, antiplatelet therapy

© 2020 Ioana Șuş et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Clopidogrel and Ticagrelor Do Not Influence Platelet Indices After Percutaneous Coronary Intervention

Publié en ligne: 29 janv. 2021

Pages: 35 - 37

Reçu: 27 juin 2020

Accepté: 02 déc. 2020

DOI: https://doi.org/10.2478/amtsb-2020-0067

Mots cléspercutaneous coronary intervention, platelets, mean platelet volume, antiplatelet therapy

© 2020 Ioana Șuş et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
percutaneous coronary intervention, platelets, mean platelet volume, antiplatelet therapy