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This paper provides a synthesis of the concept of supply chain optimization. The aim of the research is to identify a supply chain optimization process, the key aspects in carrying out this process, and at the same time to emphasize the advantages that the optimization of companies' processes brings through the mathematical modeling of logistic processes that can be useful in the optimization of supply chains. In the research methodology it is used the Simplex transport algorithm. In a practical situation of a company with 3 warehouses and 4 clients, it allowed optimizing the transport routes and getting a minimal total cost for logistical delivery.