<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Objective</bold>: This study aims to assess the effect of bone graft materials derived from pearl oyster shells on the tumor necrosis factor-alpha (TNF-α) level.
<bold>Methods</bold>: This research utilized a bone graft containing hydroxyapatite Pinctada maxima (HPM) powder obtained from pearl oyster shells. Material testing was conducted on 30 male guinea pigs aged 8-10 weeks, divided into three groups: the negative control group, the group treated solely with HPM, and the group treated with HPM combined with platelet-rich fibrin (PRF). Each treatment group was observed for 7 and 14 days. The results were analyzed using One-way ANOVA with a significance level of p&lt;0.05.
<bold>Results</bold>: The findings demonstrated a decrease in the average TNF-α levels across all groups. On observation days 7 and 14, the HPM group exhibited a significant difference compared to the negative control group, indicating reduced TNF-α levels. However, no significant difference was observed when comparing the HPM group with the HPM and PRF groups.
<bold>Conclusions</bold>: Bone grafts derived from pearl oyster shells possess high levels of hydroxyapatite, and the addition of PRF into the bone graft effectively reduces TNF-α.
</abstract>

Objective: This study aims to assess the effect of bone graft materials derived from pearl oyster shells on the tumor necrosis factor-alpha (TNF-α) level.
Methods: This research utilized a bone graft containing hydroxyapatite Pinctada maxima (HPM) powder obtained from pearl oyster shells. Material testing was conducted on 30 male guinea pigs aged 8-10 weeks, divided into three groups: the negative control group, the group treated solely with HPM, and the group treated with HPM combined with platelet-rich fibrin (PRF). Each treatment group was observed for 7 and 14 days. The results were analyzed using One-way ANOVA with a significance level of p<0.05.
Results: The findings demonstrated a decrease in the average TNF-α levels across all groups. On observation days 7 and 14, the HPM group exhibited a significant difference compared to the negative control group, indicating reduced TNF-α levels. However, no significant difference was observed when comparing the HPM group with the HPM and PRF groups.
Conclusions: Bone grafts derived from pearl oyster shells possess high levels of hydroxyapatite, and the addition of PRF into the bone graft effectively reduces TNF-α.

The effects of pearl oyster shell-derived bone grafts on TNF-alfa levels: An <italic>in vivo</italic> study in <italic>Cavia porcellus</italic>

Faculty of Dentistry Hasanuddin University

Department of Oral and Maxillofacial Surgery

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution 4.0 International License.

The effects of pearl oyster shell-derived bone grafts on TNF-alfa levels: An  study in 

Objective: This study aims to assess the effect of bone graft materials derived from pearl oyster shells on the tumor necrosis factor-alpha (TNF-α)...

The effects of pearl oyster shell-derived bone grafts on TNF-alfa levels: An in vivo study in Cavia porcellus

Publié en ligne: 03 juil. 2024

Pages: 68 - 74

Reçu: 24 oct. 2023

Accepté: 03 juin 2024

DOI: https://doi.org/10.2478/amma-2024-0015

Mots clés
bone graft, Pinctada maxima, pearl oyster shells, platelet-rich fibrin, TNF-alfa

© 2024 Sri Oktawati et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

The effects of pearl oyster shell-derived bone grafts on TNF-alfa levels: An in vivo study in Cavia porcellus

Publié en ligne: 03 juil. 2024

Pages: 68 - 74

Reçu: 24 oct. 2023

Accepté: 03 juin 2024

DOI: https://doi.org/10.2478/amma-2024-0015

Mots clésbone graft, Pinctada maxima, pearl oyster shells, platelet-rich fibrin, TNF-alfa

© 2024 Sri Oktawati et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Mots clés
bone graft, Pinctada maxima, pearl oyster shells, platelet-rich fibrin, TNF-alfa