<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Objective</bold> of this study was to identify the histopathological patterns and their frequency in testicular biopsy specimens from azoospermic patients and to categorize it according to Modified Johnsen scoring system.
<bold>Methods</bold>: Testicular biopsies from male patients with clinical diagnosis of azoospermia were included in this study. All tissue samples were fixed in buffered 10% formalin, routinely processed and stained with Hematoxylin and Eosin. All cases were examined microscopically and categorized according to the histopathological patterns and Modified Johnsen scoring system.
<bold>Results</bold>: Total 219 cases of testicular biopsies from 125 azoospermic male patients were evaluated, with 94 cases of bilateral testicular biopsy. The most prevalent age group was of 30-39 years (66.2%). The most common histological pattern was of Sertoli cell only syndrome (58.4%) while the least represented pattern was germ cell maturation arrest, seen in 4.6% cases. The most common Modified Johnsen score was 2 (66.7%). There was discordance in histologic pattern in both testes in 12.76% of patients who had bilateral testicular biopsy.
<bold>Conclusion</bold>: Our study gives an insight on the most common histopathological patterns of azoospermic patients and emphasizes the need for a better national statistics and epidemiological studies of this entity. It also points out the significance of the bilateral testicular biopsy, as both, diagnostic and therapeutic procedure.
</abstract>

Objective of this study was to identify the histopathological patterns and their frequency in testicular biopsy specimens from azoospermic patients and to categorize it according to Modified Johnsen scoring system.
Methods: Testicular biopsies from male patients with clinical diagnosis of azoospermia were included in this study. All tissue samples were fixed in buffered 10% formalin, routinely processed and stained with Hematoxylin and Eosin. All cases were examined microscopically and categorized according to the histopathological patterns and Modified Johnsen scoring system.
Results: Total 219 cases of testicular biopsies from 125 azoospermic male patients were evaluated, with 94 cases of bilateral testicular biopsy. The most prevalent age group was of 30-39 years (66.2%). The most common histological pattern was of Sertoli cell only syndrome (58.4%) while the least represented pattern was germ cell maturation arrest, seen in 4.6% cases. The most common Modified Johnsen score was 2 (66.7%). There was discordance in histologic pattern in both testes in 12.76% of patients who had bilateral testicular biopsy.
Conclusion: Our study gives an insight on the most common histopathological patterns of azoospermic patients and emphasizes the need for a better national statistics and epidemiological studies of this entity. It also points out the significance of the bilateral testicular biopsy, as both, diagnostic and therapeutic procedure.

Histological patterns of testicular biopsy in patients with azoospermia: single-institution experience

Department of Pathology, Faculty of Medicine

Department of Histology and Embryology, Faculty of Medicine

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution 4.0 International License.

Objective of this study was to identify the histopathological patterns and their frequency in testicular biopsy specimens from azoospermic patients and to...

Histological patterns of testicular biopsy in patients with azoospermia: single-institution experience

Publié en ligne: 28 déc. 2023

Pages: 252 - 255

Reçu: 10 août 2023

Accepté: 11 sept. 2023

DOI: https://doi.org/10.2478/amma-2023-0038

Mots clés
infertility, histology, testis

© 2023 Nina Čamdžić et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Histological patterns of testicular biopsy in patients with azoospermia: single-institution experience

Publié en ligne: 28 déc. 2023

Pages: 252 - 255

Reçu: 10 août 2023

Accepté: 11 sept. 2023

DOI: https://doi.org/10.2478/amma-2023-0038

Mots clésinfertility, histology, testis

© 2023 Nina Čamdžić et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Mots clés
infertility, histology, testis