<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Objective</bold>: Hereditary hemochromatosis, or primary hemochromatosis, is a recessive genetic liver disorder caused by iron accumulation in tissues. This study evaluates patients with hereditary hemochromatosis to determine correlations between clinical and laboratory data.
<bold>Methods</bold>: The data analyzed in this study was gathered from the discharge records from 2019 to 2021 of the Gastroenterology Department of the Mures Country Emergency Clinical Hospital. 15 patients with hemochromatosis were sampled during the studied period.
<bold>Results</bold>: Hepatic cirrhosis is present in 67% of the studied group of patients, 40% of patients presented hypertension and 20% of patients showed diabetes mellitus and portal hypertension. Positive correlations were obtained between serum iron and alkaline phosphatase (r=0.8536), between serum iron and lactate dehydrogenase (r=0.7381), and between serum iron and urea (r = 0.79). Positive, strong correlation between ferritin and serum iron (r=0.7719), GOT (r=0.778) and GPT (r=0.6108). total bilirubin and direct bilirubin (r = 0.85), between total bilirubin and GOT (r = 0.68) and GPT (r = 0.82).
<bold>Conclusions</bold>: Excess iron stored is influencing organ function trough reactive oxygen species, the hepatic signs being a main participant in the clinical presentation, while serum iron cause damage to other tissues such as myocardium, pancreas and kidneys. Treatment for hemochromatosis includes phlebotomies, and iron chelation with Deferoxamine.
</abstract>

Objective: Hereditary hemochromatosis, or primary hemochromatosis, is a recessive genetic liver disorder caused by iron accumulation in tissues. This study evaluates patients with hereditary hemochromatosis to determine correlations between clinical and laboratory data.
Methods: The data analyzed in this study was gathered from the discharge records from 2019 to 2021 of the Gastroenterology Department of the Mures Country Emergency Clinical Hospital. 15 patients with hemochromatosis were sampled during the studied period.
Results: Hepatic cirrhosis is present in 67% of the studied group of patients, 40% of patients presented hypertension and 20% of patients showed diabetes mellitus and portal hypertension. Positive correlations were obtained between serum iron and alkaline phosphatase (r=0.8536), between serum iron and lactate dehydrogenase (r=0.7381), and between serum iron and urea (r = 0.79). Positive, strong correlation between ferritin and serum iron (r=0.7719), GOT (r=0.778) and GPT (r=0.6108). total bilirubin and direct bilirubin (r = 0.85), between total bilirubin and GOT (r = 0.68) and GPT (r = 0.82).
Conclusions: Excess iron stored is influencing organ function trough reactive oxygen species, the hepatic signs being a main participant in the clinical presentation, while serum iron cause damage to other tissues such as myocardium, pancreas and kidneys. Treatment for hemochromatosis includes phlebotomies, and iron chelation with Deferoxamine.

Hereditary hemochromatosis: Retrospective study on clinical data from Emergency County Hospital Mures

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution 4.0 International License.

Objective: Hereditary hemochromatosis, or primary hemochromatosis, is a recessive genetic liver disorder caused by iron accumulation in tissues. This study...

Hereditary hemochromatosis: Retrospective study on clinical data from Emergency County Hospital Mures

Publié en ligne: 07 janv. 2023

Pages: 179 - 182

Reçu: 10 oct. 2022

Accepté: 11 déc. 2022

DOI: https://doi.org/10.2478/amma-2022-0031

Mots clés
hemochromatosis, iron, cirrhosis, reactive oxygen species, phlebotomy

© 2022 Victor Sigmirean, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Hereditary hemochromatosis: Retrospective study on clinical data from Emergency County Hospital Mures

Publié en ligne: 07 janv. 2023

Pages: 179 - 182

Reçu: 10 oct. 2022

Accepté: 11 déc. 2022

DOI: https://doi.org/10.2478/amma-2022-0031

Mots cléshemochromatosis, iron, cirrhosis, reactive oxygen species, phlebotomy

© 2022 Victor Sigmirean, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Mots clés
hemochromatosis, iron, cirrhosis, reactive oxygen species, phlebotomy