[
1. Sportelli C, Urso D, Jenner P, Chaudhuri KR. Metformin as a Potential Neuroprotective Agent in Prodromal Parkinson’s Disease—Viewpoint. Front. Neurol. 2020, 11: 556.10.3389/fneur.2020.00556730436732595595
]Search in Google Scholar
[
2. Sykes DA, Moore H, Stott L et al. Extrapyramidal Side Effects of Antipsychotics Are Linked to Their Association Kinetics at Dopamine D2 Receptors. Nat. Commun. 2017, 8 (1): 763.
]Search in Google Scholar
[
3. Mori T, Ito S, Kita T. Sawaguchi T. Effects of Dopamine- and Serotonin-Related Compounds on Methamphetamine-Induced Self-Injurious Behavior in Mice. J. Pharmacol. Sci. 2004, 9610.1254/jphs.FPJ04040X15599099
]Search in Google Scholar
[
4. Wiley, J. L. Antipsychotic-Induced Suppression of Locomotion in Juvenile, Adolescent and Adult Rats. Eur. J. Pharmacol. 2008, 578 (2–3), 216–221.
]Search in Google Scholar
[
5. Balijepalli S, Kenchappa RS, Boyd MR, Ravindranath V. Protein Thiol Oxidation by Haloperidol Results in Inhibition of Mitochondrial Complex I in Brain Regions: Comparison with Atypical Antipsychotics. Neurochem. Int. 2001, 38 (5), 425–435.
]Search in Google Scholar
[
6. Reinke A, Martins MR, Lima MS, Moreira JC, Dal-Pizzol F, Quevedo J. Haloperidol and Clozapine, but Not Olanzapine, Induces Oxidative Stress in Rat Brain. Neurosci. Lett. 2004, 372 (1–2), 157–160.
]Search in Google Scholar
[
7. Lu M, Su C, Qiao C, Bian Y, Ding J, Hu G. Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson’s Disease via Autophagy and Mitochondrial ROS Clearance. Int. J. Neuropsychopharmacol. 2016, 19 (9), pyw047.
]Search in Google Scholar
[
8. Kang HJ, Lee SS, Lee CH et al. Neurotoxic pyridinium metabolites of haloperidol are substrates of human organic cation transporters. Drug Metab. Dispos. 2006, 34 (7), 1145–1151.
]Search in Google Scholar
[
9. Wu X, Kekuda R, Huang W et al. Identity of the Organic Cation Transporter OCT3 as the Extraneuronal Monoamine Transporter (Uptake2) and Evidence for the Expression of the Transporter in the Brain. J. Biol. Chem. 1998, 273 (49), 32776–32786.
]Search in Google Scholar
[
10. Schmitt U, Dahmen N, Fischer V et al Chronic Oral Haloperidol and Clozapine in Rats: A Behavioral Evaluation. Neuropsychobiology 1999, 39 (2), 86–91.10.1159/00002656610072665
]Search in Google Scholar
[
11. Pryor, R.; Cabreiro, F. Repurposing Metformin: An Old Drug with New Tricks in Its Binding Pockets. Biochem. J. 2015, 471 (3), 307–322.
]Search in Google Scholar
[
12. Rena G, Lang CC. Repurposing Metformin for Cardiovascular Disease. Circulation 2018, 137 (5), 422–424.10.1161/CIRCULATIONAHA.117.03173529378754
]Search in Google Scholar
[
13. Zuliani I, Urbinati C, Valenti D et al. The Anti-Diabetic Drug Metformin Rescues Aberrant Mitochondrial Activity and Restrains Oxidative Stress in a Female Mouse Model of Rett Syndrome. J. Clin. Med. 2020, 9 (6), 1669.
]Search in Google Scholar
[
14. Martin-Montalvo A, Mercken EM, Mitchell SJ et al. Metformin Improves Healthspan and Lifespan in Mice. Nat. Commun. 2013, 4 (1), 2192.
]Search in Google Scholar
[
15. Wahlqvist ML, Lee MS, Hsu CC, Chuang SY, Lee JT, Tsai HN. Metformin-Inclusive Sulfonylurea Therapy Reduces the Risk of Parkinson’s Disease Occurring with Type 2 Diabetes in a Taiwanese Population Cohort. Parkinsonism Relat. Disord. 2012, 18 (6), 753–758.
]Search in Google Scholar
[
16. Engelhard KA, Marchetta P, Schwarting RKW, Melo-Thomas L. Haloperidol–Induced Catalepsy Is Ameliorated by Deep Brain Stimulation of the Inferior Colliculus. Sci. Rep. 2018, 8 (1), 2216.
]Search in Google Scholar
[
17. Lu M, Chen H, Nie F, Wei X, Tao Z, Ma J. The Potential Role of Metformin in the Treatment of Parkinson’s Disease. J. Bio-X Res. 2020, 3 (1), 27–35.
]Search in Google Scholar
[
18. Patil SP, Jain PD, Ghumatkar PJ, Tambe R, Sathaye S. Neuroprotective Effect of Metformin in MPTP-Induced Parkinson’s Disease in Mice. Neuroscience 2014, 277, 747–754.10.1016/j.neuroscience.2014.07.04625108167
]Search in Google Scholar
[
19. Rotermund C, Machetanz G, Fitzgerald JC. The Therapeutic Potential of Metformin in Neurodegenerative Diseases. Front. Endocrinol. 2018, 9, 400.
]Search in Google Scholar
[
20. Pillai A, Dhandapani KM, Pillai BA, Terry AV Jr, Mahadik SP. Erythropoietin prevents haloperidol treatment-induced neuronal apoptosis through regulation of BDNF. Neuropsychopharmacology. 2008, 33 (8), 1942-51.
]Search in Google Scholar
[
21. Zhang XF, Tan BK. Antihyperglycaemic and anti-oxidant properties of Andrographis paniculata in normal and diabetic rats. Clin Exp Pharmacol Physiol. 2000, 27(5-6), 358-63.
]Search in Google Scholar
[
22. Tsai CM, Kuo HC, Hsu CN, Huang LT, Tain YL. Metformin reduces asymmetric dimethylarginine and prevents hypertension in spontaneously hypertensive rats. Transl Res. 2014, 164(6), 452-9.
]Search in Google Scholar
[
23. Keshavarzi S, Kermanshahi S, Karami L, Motaghinejad M, Motevalian M, Sadr S. Protective role of metformin against methamphetamine induced anxiety, depression, cognition impairment and neurodegeneration in rat: The role of CREB/BDNF and Akt/GSK3 signaling pathways. Neurotoxicology. 2019, 72, 74-84.
]Search in Google Scholar
[
24. Alharbi I, Alharbi H, Almogbel Y, Alalwan A, Alhowail A. Effect of Metformin on Doxorubicin-Induced Memory Dysfunction. Brain Sci. 2020, 10(3), 152.
]Search in Google Scholar
[
25. Bricker B, Sampson D, Ablordeppey SY. Evaluation of the potential of antipsychotic agents to induce catalepsy in rats: assessment of a new, commercially available, semi-automated instrument. Pharmacol Biochem Behav. 2014, 120, 109-16.
]Search in Google Scholar
[
26. Alhowail AH, Chigurupati S, Sajid S, Mani V. Ameliorative Effect of Metformin on Cyclophosphamide-Induced Memory Impairment in Mice. Eur Rev Med Pharmacol Sci. 2019, 23(21), 9660-9666.
]Search in Google Scholar
[
27. Feyissa DD, Aher YD, Engidawork E, Höger H, Lubec G, Korz V. Individual Differences in Male Rats in a Behavioral Test Battery: A Multivariate Statistical Approach. Front Behav Neurosci. 2017, 11, 26.
]Search in Google Scholar
[
28. Rajagopal L, Massey BW, Huang M, Oyamada Y, Meltzer HY. The novel object recognition test in rodents in relation to cognitive impairment in schizophrenia. Curr Pharm Des. 2014, 20(31), 5104-14.
]Search in Google Scholar
[
29. Antunes M, Biala G. The novel object recognition memory: neurobiology, test procedure, and its modifications. Cogn Process. 2012, 13(2), 93-110.
]Search in Google Scholar
[
30. Orsetti M, Colella L, Dellarole A, Canonico PL, Ghi P. Modification of spatial recognition memory and object discrimination after chronic administration of haloperidol, amitriptyline, sodium valproate or olanzapine in normal and anhedonic rats. Int J Neuropsychopharmacol. 2007, 10(3), 345-57.
]Search in Google Scholar
[
31. Saeed A, Shakir L, Khan MA, Ali A, Zaidi AA. Haloperidol Induced Parkinson’s Disease Mice Model and Motor-Function Modulation with Pyridine-3-Carboxylic Acid. Biomed. Res. Ther. 2017, 4 (05), 1305.
]Search in Google Scholar
[
32. Boulay D, Depoortere R, Oblin A, Sanger DJ, Schoemaker H, Perrault G. Haloperidol-Induced Catalepsy Is Absent in Dopamine D2, but Maintained in Dopamine D3 Receptor Knock-out Mice. Eur. J. Pharmacol. 2000, 391 (1–2), 63–73.
]Search in Google Scholar
[
33. Adedeji HA, Ishola IO, Adeyemi OO. Novel Action of Metformin in the Prevention of Haloperidol-Induced Catalepsy in Mice: Potential in the Treatment of Parkinson’s Disease? Prog. Neuropsychopharmacol. Biol. Psychiatry 2014, 48, 245–251.10.1016/j.pnpbp.2013.10.01424513020
]Search in Google Scholar
[
34. Ramírez-Jarquín UN, Shahani N, Pryor W, Usiello A, Subramanian, S. The Mammalian Target of Rapamycin (MTOR) Kinase Mediates Haloperidol-Induced Cataleptic Behavior. Transl. Psychiatry 2020, 10 (1), 22.10.1038/s41398-020-01014-x753220833009372
]Search in Google Scholar
[
35. Li W, Chaudhari K, Shetty R et al. Metformin Alters Locomotor and Cognitive Function and Brain Metabolism in Normoglycemic Mice. Aging Dis. 2019, 10 (5), 949.
]Search in Google Scholar
[
36. Zemdegs J, Martin H, Pintana H et al. Metformin Promotes Anxiolytic and Antidepressant-Like Responses in Insulin-Resistant Mice by Decreasing Circulating Branched-Chain Amino Acids. J Neurosci. 2019, 39(30), 5935-5948.
]Search in Google Scholar
[
37. Alfaras I, Mitchell SJ, Mora H et al. Health benefits of late-onset metformin treatment every other week in mice. NPJ Aging Mech Dis. 2017, 3, 16.
]Search in Google Scholar