Severe Subconjunctival Bleeding in a Patient with Concomitant Use of Warfarin and Valproic Acid

1 Yoon HW, Giraldo EA, Wijdicks EF. Valproic acid and warfarin: an underrecognized drug interaction. Neurocrit Care. 2011 Aug; 15(1):182-5. doi: 10.1007/s12028-011-9544-5. Search in Google Scholar

2 Zhou C, Sui Y, Zhao W, et al. The critical interaction between valproate sodium and warfarin: case report and review. BMC Pharmacol Toxicol. 2018 Oct 1; 19(1):60. doi: 10.1186/ s40360-018-0251-0. Search in Google Scholar

3 Anderson SL, Marrs JC. Probable Interaction Between Warfarin and Divalproex Sodium. J Pharm Technol. 2014 Feb; 30(1):8-12. doi: 10.1177/8755122513514379. Epub 2013 Nov 22. Search in Google Scholar

4 Bruun E, Virta LJ, Kalviainen R, et al. Co-morbidity and clinically significant interactions between antiepileptic drugs and other drugs in elderly patients with newly diagnosed epilepsy. Epilepsy Behav. 2017; 73:71–76. doi: 10.1016/j.yebeh.2017.05.022. Search in Google Scholar

5 Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs. LancetNeurol. 2003; 2(6):347-356. doi: 10.1016/ S1474-4422(03)00409-5. Search in Google Scholar

6 Cun-Li Wang, Victor Chien-Chia Wu, Kuo-Hsuan Chang, et al. Assessing major bleeding risk in atrial fibrillation patients concurrently taking non-vitamin K antagonist oral anticoagu- lants and antiepileptic drugs, European Heart Journal - Cardiovascular Pharmacotherapy, May 2020, 6 (3): 147-154. Search in Google Scholar

7 Kouchaki B, Salehifar E, Janbabai G, et al. Major Interaction between Warfarin and Na Valproate: A Case Report. J Pharm Care 2014; 2 (4): 183-185. Search in Google Scholar

8 Robertson P Jr, Hellriegel ET. Clinical pharmacokinetic profile of modafinil. Clin Pharmacokinet 2003; 42:123-37. Search in Google Scholar

9 Zeller JA, Schlesinger S, Runge U, et al. Influence of valproate monotherapy on platelet activation and hematologic values. Epilepsia 1999; 40: 186-9. Search in Google Scholar

10 Jimenez-Ruiz A, Gutierrez-Castillo A, Ruiz-Sandoval JL. Fatal Intracranial Hemorrhage Associated with Oral Warfarin Use. Cureus. 2018 Nov 12; 10(11):e3571. doi:10.7759/cureus.3571. Search in Google Scholar

11 Teo KC, Mahboobani NR, Lee R, et al. Warfarin associated intracerebral hemorrhage in Hong Kong Chinese. Neurol Res. 2014 Feb; 36(2):143-9. doi:10.1179/1743132813Y.0000000275. Epub 2013 Dec 6. Search in Google Scholar

12 Morotti A, Goldstein, J. N. Anticoagulant-Associated Intracerebral Hemorrhage. Brain Hemorrhages. 2020, 1(1), 89-94. doi:10.1016/j.hest.2020.01.001 Search in Google Scholar