[1. Kapp N. WHO provider brief on hormonal contraception and liver disease. Contraception. 2009; 80:325-326.10.1016/j.contraception.2009.01.020]Search in Google Scholar
[2. Schwartz JL, Gabelnick HL. Current contraceptive research. Perspect Sexualm Reprod Health. 2002; 34(6):310-316.10.2307/3097750]Search in Google Scholar
[3. Stanczyk FZ, Archer DF, Bhavnani BR. Ethinyl estradiol and 17β-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment. Contraception. 2013; 87(6):706-727.10.1016/j.contraception.2012.12.011]Search in Google Scholar
[4. Zhang K, Fent K. Determination of two progestin metabolites (17α hydroxypregnanolone and pregnanediol) and different classes of steroids (androgens, estrogens, corticosteroids, progestins) in rivers and waste waters by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). Sci Total Environ. 2018; 610-611:1164-1172.10.1016/j.scitotenv.2017.08.114]Search in Google Scholar
[5. Golobof A, Kiley J. The current status of oral contraceptives: progress and recent innovations. Semin Reprod Med. 2016; 34(3):145-151.10.1055/s-0036-1572546]Search in Google Scholar
[6. Dikke GB. Protective potential and safety of multiphase combined oralcontraception based on natural estrogen in mature women. Problems Reprod. 2018; 23(3):27-33.10.17116/repro201824327]Search in Google Scholar
[7. Rivera R, Yacobson I, Grimes D. The mechanism of action of hormonal contraceptives and intrauterine contraceptive devices. Am J Obstet Gynecol. 1999; 181(5):1263-1269.10.1016/S0002-9378(99)70120-1]Search in Google Scholar
[8. Nelson AL, Cwiak C. Combined oral contraceptives. In: Hatcher RA, Trussel J, Nelson A, et al. (Eds.). Contraceptive Technology. 20th ed. New York, Ardent Media. 2011, 249-342.]Search in Google Scholar
[9. United Nations. Population growth and universal access to reproductive health. Report of the United Nations Population Division. Department of Economic and Social Affairs. 2014. http://www.un.org/en/development/desa/population/publications/pdf/popfacts/PopFacts_2014-6.pdf. Accessed on June 24, 2017.]Search in Google Scholar
[10. De Leo V, Musacchio MC, Cappelli V, et al. Hormonal contraceptives: pharmacology tailored to women’s health. Human Reprod Update. 2016; 22(5):634-646.10.1093/humupd/dmw01627307386]Search in Google Scholar
[11. Michels KA, Brinton LA, Pfeiffer RM, et al. Oral contraceptive use and risks of cancer in the NIH-AARP diet and health study. Am J Epidemiol. 2018; 187(8):1630-1641.10.1093/aje/kwx388648753529394309]Search in Google Scholar
[12. Toffoletto S, Lanzenberger R, Gingnell M, et al. Emotional and cognitive functional imaging of estrogen and progester one effects in the female human brain: a systematic review. Psychoneuroendocrinol. 2014; 50:28-52.10.1016/j.psyneuen.2014.07.02525222701]Search in Google Scholar
[13. Gingnell M, Engman J, Frick A, et al. Oral contraceptive use changes brain activity and mood in women with previous negative effect on the pill- A double-blinded, placebo-controlled randomized trial of a levonorgestrel-containing combined oral contraceptive. Psychoneuroendocrinol, 2013; 38(7):1133-1144.10.1016/j.psyneuen.2012.11.006]Search in Google Scholar
[14. Pletzer B, Kronbichler M, Kerschbaum H. Differential effects of androgenic and anti-androgenic progestins on fusiform and frontal gray matter volume and face recognition performance. Brain Res. 2015; 1596:108-115.10.1016/j.brainres.2014.11.025]Search in Google Scholar
[15. Gresack JE, Frick KM. Effects of continuous and intermittent estrogen treatments on memory in aging female mice. Brain Res. 2006; 1115:135-147.10.1016/j.brainres.2006.07.067]Search in Google Scholar
[16. Mennenga SE, Gerson JE, Koebele SV, et al. Understanding the cognitive impact of the contraceptive estrogen ethinyl estradiol: tonic and cyclic administration impairs memory, and performance correlates with basal forebrain cholinergic system integrity. Psychoneuroendocrinol. 2015; 54:1-13.10.1016/j.psyneuen.2015.01.002]Search in Google Scholar
[17. Snihur AW, Hampson E, Cain DP. Estradiol and corticosterone independently impair spatial navigation in the Morris water maze in adult female rats. Behav Brain Res. 2008; 187(1):56-66.10.1016/j.bbr.2007.08.023]Search in Google Scholar
[18. Frye CA, Walf AA. Progesterone to ovariectomized mice enhances cognitive performance in the spontaneous alternation, object recognition, but not placement, water maze, and contextual and cued conditioned fear tasks. Neurobiol Learn Mem. 2008; 90:171-177.10.1016/j.nlm.2008.03.005]Search in Google Scholar
[19. Braden BB, Andrews MG, Acosta JI, et al. A comparison of progestins within three classes: Differential effects on learning and memory in the aging surgically menopausal rat. Behav Brain Res. 2017; 322(Pt B):258-268.10.1016/j.bbr.2016.06.053]Search in Google Scholar
[20. Johansson I-M, Birzniece V, Lindblad C, et al. Allopregnanolone inhibits learning in the Morris water maze. Brain Res. 2002; 934(2):125-131.10.1016/S0006-8993(02)02414-9]Search in Google Scholar
[21. Nielsen SE, Segal SK, Worden IV, et al. Hormonal contraception use alters stress responses and emotional memory. Biol Psychol. 2013; 92(2):257-266.10.1016/j.biopsycho.2012.10.007355860323131613]Search in Google Scholar
[22. Andreano J, Cahill L, Petersen N, et al. Oral contraceptive pill use is associated with localized decreases in cortical thickness. Human Brain mapping. Arch Dis Child. 2015; 62(4):362-369.]Search in Google Scholar
[23. Kiernan JA, Rajakumar N. Barr’s The Human Nervous System: An Anatomical Viewpoint. Philadelphia, Wolters Kluwer/Lippincott Williams & Wilkins. 2014.]Search in Google Scholar
[24. Bruchey AK, Gonzalez-Lima F. Enhanced metabolic capacity of the frontal cerebral cortex after Pavlovian conditioning. Neurosci. 2008; 152(2):299-307.10.1016/j.neuroscience.2007.08.036234648518291593]Search in Google Scholar
[25. Méndez-López M, Méndez M, López L, et al. Spatial working memory in young male and female rats: Involvement of different limbic system regions revealed by cytochrome oxidase activity. Neurosci Res. 2009; 65:28-34.10.1016/j.neures.2009.05.001]Search in Google Scholar
[26. Devineni D, Skee D, Vaccaro N, et al. Pharmacokinetics and pharmacodynamics of a transdermal contraceptive patch and an oral contraceptive. J Clin Pharmacol. 2007; 47:497–509.10.1177/0091270006297919]Search in Google Scholar
[27. Bromley-Brits K, Deng Y, Song W. Morris water maze test for learning and memory deficits in Alzheimer‘s disease model mice. J Vis Exp. 2011; 53:2920.10.3791/2920]Search in Google Scholar
[28. Barnhart CD, Yang D, Lein PJ. Using the Morris water maze to assess spatial learning and memory in weanling mice. PLoS One. 2015; 10(4):e0124521.10.1371/journal.pone.0124521]Search in Google Scholar
[29. Terry AV. Spatial navigation (water maze) tasks. In; Buccafusco JJ (Ed.). Methods of Behavior Analysis in Neuroscience. 2nd ed. Boca Raton (FL), CRC Press/Taylor & Francis. 2009.]Search in Google Scholar
[30. Pletzer B, Kronbichler M, Aichhorn M, et al. Menstrual cycle and hormonal contraceptive use modulate human brain structure. Brain Res. 2010; 1348(12):55-62.10.1016/j.brainres.2010.06.019]Search in Google Scholar
[31. Griksiene R, Ruksenas O. Effects of hormonal contraceptives on mental rotation and verbal fluency. Psychoneuroendocrinol. 2011; 36(8):1239-1248.10.1016/j.psyneuen.2011.03.001]Search in Google Scholar
[32. Egan KR, Gleason CE. Longer duration of hormonal contraceptive use predicts better cognitive outcomes later in life. J Women Health (Larchmt). 2012; 21(12):1259-1266.10.1089/jwh.2012.3522]Search in Google Scholar
[33. Martins DP, Semenoff TADV, Borges ÁH, et al. Chronic stress associated to contraceptives use on the progression of ligature-induced periodontitis in rats. Revista de Odontologia da UNESP. 2016; 45(5):290-296.10.1590/1807-2577.04116]Search in Google Scholar
[34. McEwen BS, Mirsky AE. Stress-induced remodelling of hippocampal CA3 pyramidal neurons. Brain Res. 2016; 1645: 50-54.10.1016/j.brainres.2015.12.043]Search in Google Scholar
[35. Watanabe Y, Gould E, McEwen BS. Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons. Brain Res. 1992; 588(2):341-345.10.1016/0006-8993(92)91597-8]Search in Google Scholar
[36. Ekanem TB, Nwakanma AA, Eluwa MA, Ekong MB. Histological and immunohistochemical alterations of the amygdala of female Wistar rats administered oral ethinyl estradiol and levonogestrel combination. W J Biomed Res. 2020; 7(1):21-26.]Search in Google Scholar
[37. Conrad CD, LeDoux JE, Magarinos AM, et al. Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy. Behav Neurosci. 1999; 113: 902-913.10.1037/0735-7044.113.5.902]Search in Google Scholar
[38. Butterfield DA, Lange ML. Multifunctional roles of enolase in Alzheimer’s disease brain: beyond altered glucose metabolism. J Neurochem. 2009; 111:915-933.10.1111/j.1471-4159.2009.06397.x]Search in Google Scholar
[39. Ogundele OM, Madukwe J, Omotosho OA, et al. Immunohistochemical localization of neuron specific enolase and CD3 lymphocyte activation. J Med Sci. 2012; 12:92-98.10.3923/jms.2012.92.98]Search in Google Scholar
[40. Hattori T, Takei N, Mizuno Y, et al. Neurotrophic and neuroprotective effects of neuron-specific enolase on cultured neurons from embryonic rat brain. Neurosci Res. 1995; 21(3):191-198.10.1016/0168-0102(94)00849-B]Search in Google Scholar
[41. Rosenstein JM. Developmental expression of neuron-specific enolase immunoreactivity and cytochrome oxidase activity in neocortical transplants. Exp Neurol. 1993; 124(2): 208-218.10.1006/exnr.1993.11918287924]Search in Google Scholar
[42. Knapman A, Kaltwasser SF, Martins-de-Souza D, et al. Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism. Eur J Neurosci. 2012; 35(3):412-422.10.1111/j.1460-9568.2011.07968.x22288479]Search in Google Scholar
[43. Oken BS, Chamine I, Wakeland W. A systems approach to stress, stressors and resilience in humans. Behav Brain Res. 2015; 282:144-154.10.1016/j.bbr.2014.12.047432392325549855]Search in Google Scholar
[44. Paradiso K, Zhang J, Steinbach J. The C terminus of the human nicotinic alpha4beta2 receptor forms a binding site required for potentiation by an estrogenic steroid. J Neurosci. 2001; 21(17):6561-6568.10.1523/JNEUROSCI.21-17-06561.2001]Search in Google Scholar
[45. Nagele RG, Wegiel J, Venkataraman V, et al. Contribution of glial cells to the development of amyloid plaques in Alzheimer’s disease. Neurobiol Aging. 2004: 25; 663-674.10.1016/j.neurobiolaging.2004.01.00715172746]Search in Google Scholar
[46. Pekny M, Nilsson M. Astrocyte activation and reactive gliosis. Glia. 2005; 50(4):427-434.10.1002/glia.2020715846805]Search in Google Scholar
[47. Pekny M, Pekna A. Astrocyte intermediate filaments in CNS pathologies and regeneration. J Pathol. 2004; 204:428-437.10.1002/path.1645]Search in Google Scholar
[48. Nielsen SE, Ertman N, Lakhani YS, et al. Hormonal contraception usage is associated with altered memory for an emotional story. Neurobiol Learn Mem. 2011; 96(2):378.10.1016/j.nlm.2011.06.013]Search in Google Scholar
[49. Woolley C, Gould E, McEwen BS. Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons. Brain Res. 1990; 531:225-231.10.1016/0006-8993(90)90778-A]Search in Google Scholar
[50. Greenstein B, Greenstein A. Color Atlas of Neuroscience: Neuroanatomy and Neurophysiology. New York: Thieme. 2000.10.1055/b-005-148864]Search in Google Scholar