<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Background:</bold> The diagnosis of chronic kidney disease (CKD) is usually delayed, when significant functional renal impairment has already occurred. The diagnosis is complex and clinical and laboratory investigations play a crucial role. There are well-established markers of CKD – serum creatinine and cystatin C. However, the search for new reliable biomarkers that aid in the assessment of kidney function and predict the evolution of the disease is still in progress.<bold>Objective: T</bold>o investigate the role of serum uromodulin (sUmod) as a marker for early diagnosis of renal impairment in patients with CKD.<bold>Materials and Methods:</bold> We investigated 70 patients, 28 male and 42 female, mean age 56.53 ± 11.753, with CKD in a prospective observational study. All patients were admitted to the Clinic of Nephrology at the “St. Ivan Rilski” University Hospital between April and November 2019. After obtaining written informed consent, laboratory blood and urine tests, abdominal ultrasound and sUmod investigations were performed in all patients.<bold>Results:</bold> Plasma uromodulin levels showed decrease with the increasing of the severity of renal impairment. sUmod displayed inverse correlation with serum creatinine (r = -0.467, p &lt; 0.0001), cystatin C (r = -0.430, p &lt; 0.0001) and urea (r = -0.495, p &lt; 0.0001) and a positive correlation with eGFR (r = 0.628, p &lt; 0.0001).<bold>Conclusion:</bold> The results of our study show that sUmod levels significantly correlate with all established laboratory parameters used for the evaluation of renal impairment. It can be used as a potential early biomarker for CKD diagnosis.</abstract>

Background: The diagnosis of chronic kidney disease (CKD) is usually delayed, when significant functional renal impairment has already occurred. The diagnosis is complex and clinical and laboratory investigations play a crucial role. There are well-established markers of CKD – serum creatinine and cystatin C. However, the search for new reliable biomarkers that aid in the assessment of kidney function and predict the evolution of the disease is still in progress.Objective: To investigate the role of serum uromodulin (sUmod) as a marker for early diagnosis of renal impairment in patients with CKD.Materials and Methods: We investigated 70 patients, 28 male and 42 female, mean age 56.53 ± 11.753, with CKD in a prospective observational study. All patients were admitted to the Clinic of Nephrology at the “St. Ivan Rilski” University Hospital between April and November 2019. After obtaining written informed consent, laboratory blood and urine tests, abdominal ultrasound and sUmod investigations were performed in all patients.Results: Plasma uromodulin levels showed decrease with the increasing of the severity of renal impairment. sUmod displayed inverse correlation with serum creatinine (r = -0.467, p < 0.0001), cystatin C (r = -0.430, p < 0.0001) and urea (r = -0.495, p < 0.0001) and a positive correlation with eGFR (r = 0.628, p < 0.0001).Conclusion: The results of our study show that sUmod levels significantly correlate with all established laboratory parameters used for the evaluation of renal impairment. It can be used as a potential early biomarker for CKD diagnosis.

Role of Serum Uromodulin in the Early Diagnosis of Chronic Kidney Disease

Clinic of Nephrology, University Hospital “Sv. Ivan Rilski”, Medical University – Sofia

University Hospital “Sv. Ivan Rilski” – Sofia

Department of Internal Medicine, University Hospital “Alexandrovska”, Medical University – Sofia

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Role of Serum Uromodulin in the Early Diagnosis of Chronic Kidney Disease"}

Background: The diagnosis of chronic kidney disease (CKD) is usually delayed, when significant functional renal impairment has already occurred. The diagnosis...

Role of Serum Uromodulin in the Early Diagnosis of Chronic Kidney Disease

Publié en ligne: 05 mai 2021

Pages: 13 - 16

Reçu: 24 mars 2020

Accepté: 09 juil. 2020

DOI: https://doi.org/10.2478/amb-2021-0002

Mots clés
serum uromodulin, chronic kidney disease, biomarker, serum creatinine, cystatin C

© 2021 D. Genov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Role of Serum Uromodulin in the Early Diagnosis of Chronic Kidney Disease

Publié en ligne: 05 mai 2021

Pages: 13 - 16

Reçu: 24 mars 2020

Accepté: 09 juil. 2020

DOI: https://doi.org/10.2478/amb-2021-0002

Mots clésserum uromodulin, chronic kidney disease, biomarker, serum creatinine, cystatin C

© 2021 D. Genov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
serum uromodulin, chronic kidney disease, biomarker, serum creatinine, cystatin C