<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Growth factors (GFs) are bioactive molecules participating in organ development, tissue regeneration and repair. They are protein molecules with a relatively low molecular weight and are released by activated platelets. Platelet-derived growth factor (PDGF) is one of the GFs of highest amount in human platelets. It is known to stimulate cell proliferation and extracellular matrix synthesis, as well as angiogenesis in healthy tissues and neoplasms. However, most of the studies in the literature demonstrate the influence of PDGF on tissue regeneration without revealing its intimate mechanisms of action on different cell types. In the current review we emphasis on the effects of PDGF in order to stimulate various biological processes in wide number of pre-clinical and clinical studies.</p></abstract>

Growth factors (GFs) are bioactive molecules participating in organ development, tissue regeneration and repair. They are protein molecules with a relatively low molecular weight and are released by activated platelets. Platelet-derived growth factor (PDGF) is one of the GFs of highest amount in human platelets. It is known to stimulate cell proliferation and extracellular matrix synthesis, as well as angiogenesis in healthy tissues and neoplasms. However, most of the studies in the literature demonstrate the influence of PDGF on tissue regeneration without revealing its intimate mechanisms of action on different cell types. In the current review we emphasis on the effects of PDGF in order to stimulate various biological processes in wide number of pre-clinical and clinical studies.

RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview

Department of Dental, Oral and Maxillofacial Surgery, Faculty of Dental Medicine

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Growth factors (GFs) are bioactive molecules participating in organ development, tissue regeneration and repair. They are protein molecules with a relatively...

RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview

Publié en ligne: 14 oct. 2020

Pages: 61 - 66

Reçu: 18 juil. 2019

Accepté: 18 août 2019

DOI: https://doi.org/10.2478/amb-2020-0037

Mots clés
growth factors, platelet-derived growth factor, PDGF, oral surgery

© 2020 Z. Mihaylova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview

Publié en ligne: 14 oct. 2020

Pages: 61 - 66

Reçu: 18 juil. 2019

Accepté: 18 août 2019

DOI: https://doi.org/10.2478/amb-2020-0037

Mots clésgrowth factors, platelet-derived growth factor, PDGF, oral surgery

© 2020 Z. Mihaylova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
growth factors, platelet-derived growth factor, PDGF, oral surgery