Galleria Mellonella Larvae as an In vitro Model for Testing Microbial Pathogenicity
, , , et
09 nov. 2023
À propos de cet article
Publié en ligne: 09 nov. 2023
Pages: 173 - 182
Reçu: 01 juil. 2023
Accepté: 01 sept. 2023
DOI: https://doi.org/10.2478/am-2023-0015
Mots clés
© 2023 Dawid Gniazdo et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Scoring system for G_ mellonella larvae, modified from (Loh et al_ 2013)_
| Category | Description | Score |
|---|---|---|
| Activity | No activity | 0 |
| Active | 3 | |
| Melanization | Complete melanization | 0 |
| Single dark spots on larvae | 2 | |
| No melanization | 4 |
Antibacterial substances tested in G_ mellonella larvae
| Bacterial species | Studies | References |
|---|---|---|
| prevention of colonisation on medical foreign bodies (in vivo model of implant infection) | (Materazzi |
|
| virulence | ( |
|
| testing an antibacterial hydrogel containing the peptide (Naphthalene-2-ly)-acetyl-diphenylalanine-dilysine-OH (NapFFKK-OH) | ( |
|
| in vivo antimicrobial activity | ( |
|
| in vivo efficacy of cefazolin and fosfomycin in the treatment of MRSA infections | ( |
|
| in vivo efficacy of phage preparations: staphylococcal bacteriophage (containing monophage Sb-1) and bacteriophage mixture (PYO) | ( |
|
| infection model associated with biofilm on stainless steel and titanium implants | ( |
|
| biofilm formation inside the larvae | ( |
|
| resistance to infection | ( |
|
| regulation of humoral immunity by photodynamic therapy (PDT) | ( |
|
| maximum tolerated dose (MTD) of PPT, NNC, TBB, GW4064 and PD198306 | ( |
|
| toxicity of CM3a (5-maleimide-substituted chromone compounds) | ( |
|
| evaluation of the activity of bacteriophage 191219 against biofilm on metal implants with and without antibiotics | ( |
|
| antimicrobial activity of diethyldithiocarbamate and copper ions | ( |
|
| production of compounds with antimicrobial activity | ( |
|
| virulence | ( |
|
| virulence | ( |
|
| testing of an antibacterial hydrogel containing a peptide (Naphthalene-2-ly)-acetyl-diphenylalanine-dilysine-OH (NapFFKK-OH) | ( |
|
| antimicrobial activity of diethyldithiocarbamate and copper ions | ( |
|
| testing of an antibacterial hydrogel containing a peptide (Naphthalene-2-ly)-acetyl-diphenylalanine-dilysine-OH (NapFFKK-OH) | ( |
|
| virulence | ( |
|
| in vivo antimicrobial efficacy of lactoferricin | ( |
|
| in vivo antimicrobial efficacy of indolicidin | ( |
|
| microRNA expression (miRNA) | ( |
|
| photodynamic therapy activity (PDT) | (Garcez |
|
| antimicrobial activity of the combination of PMB and LL-37 | ( |
|
| testing of an antibacterial hydrogel containing a peptide (Naphthalene-2-ly)-acetyl-diphenylalanine-dilysine-OH (NapFFKK-OH) | ( |
|
| virulence | ( |
|
| antimicrobial activity of silver nanoparticles against UCBPP-PA14 strain | ( |
|
| antimicrobial activity of pyokines S5 and AP41 | ( |
|
| antimicrobial activity of the combination of PMB and LL-37 | ( |
|
| iron homeostasis | ( |
Antifungal compounds tested in G_ mellonella larvae
| Fungus species | Research carried out | References |
|---|---|---|
| resistance to infection | ( |
|
| antifungal activity of zinc oxide nanoparticles | ( |
|
| antifungal activity of 4-chloro-3-nitrophenyl-difluorojodomethylsulfone | ( |
|
| antifungal activity of |
( |
|
| study of |
( |
|
| virulence | ( |
|
| study on linking infection to apoptosis and changes in caspase activity in hemocytes | ( |
|
| study of the immune response to α-1,3-glucan | ( |
|
| virulence | ( |
|
| virulence | ( |
|
| study of the effect of Hsp60 protein on biofilm | ( |
|
| virulence | ( |
|
| study on the role of melanin during infection | (Smith |
|
| virulence | ( |
|
| testing the innate immune response | ( |
|
| virulence | ( |
|
| study on the role of |
( |