<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Viral pathogens are major concern nowadays. Bacterial CRISPR/Cas systems help in defending the host body against different pathogens including viruses too. This system contains restriction enzymes that introduce dsDNA breaks on target site to make the virus non-functional by damaging its genes. Coronavirus, HIV and Herpes viruses are causing mortality all around the world. To control the spread of disease, early detection and treatment is required. CRISPR system due to its high efficiency provides a platform to restrict the viral entry into host cell, viral genome editing and eliminate the latent infections. In this review, the CRISPR strategies against three major viral diseases are put under consideration: Coronavirus, Acquired Immunodeficiency Syndrome and Herpesvirus associated diseases. Three CRISPR/Cas systems have been discussed including CRISPR/Cas12, CRISPR/Cas9 and CRISPR/Cas13 that are used against the above listed viruses.</p>
</abstract>

Viral pathogens are major concern nowadays. Bacterial CRISPR/Cas systems help in defending the host body against different pathogens including viruses too. This system contains restriction enzymes that introduce dsDNA breaks on target site to make the virus non-functional by damaging its genes. Coronavirus, HIV and Herpes viruses are causing mortality all around the world. To control the spread of disease, early detection and treatment is required. CRISPR system due to its high efficiency provides a platform to restrict the viral entry into host cell, viral genome editing and eliminate the latent infections. In this review, the CRISPR strategies against three major viral diseases are put under consideration: Coronavirus, Acquired Immunodeficiency Syndrome and Herpesvirus associated diseases. Three CRISPR/Cas systems have been discussed including CRISPR/Cas12, CRISPR/Cas9 and CRISPR/Cas13 that are used against the above listed viruses.

CRISPR/Cas System: An Effective Tool Against Pathogenic Diseases

Advancements of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"CRISPR/Cas System: An Effective Tool Against Pathogenic Diseases"}

Viral pathogens are major concern nowadays. Bacterial CRISPR/Cas systems help in defending the host body against different pathogens including viruses too....

CRISPR/Cas System: An Effective Tool Against Pathogenic Diseases

Publié en ligne: 26 juin 2023

Pages: 87 - 99

Reçu: 01 nov. 2022

Accepté: 01 déc. 2022

DOI: https://doi.org/10.2478/am-2023-0009

Mots clés
AIDS, ABACAS, COVID-19, CRISPR/Cas system, DETECTR, Herpesvirus, PAC-MAN, SHERLOCK

© 2023 Shakira Aslam et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

CRISPR/Cas System: An Effective Tool Against Pathogenic Diseases

Publié en ligne: 26 juin 2023

Pages: 87 - 99

Reçu: 01 nov. 2022

Accepté: 01 déc. 2022

DOI: https://doi.org/10.2478/am-2023-0009

Mots clésAIDS, ABACAS, COVID-19, CRISPR/Cas system, DETECTR, Herpesvirus, PAC-MAN, SHERLOCK

© 2023 Shakira Aslam et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
AIDS, ABACAS, COVID-19, CRISPR/Cas system, DETECTR, Herpesvirus, PAC-MAN, SHERLOCK