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<p>Foot-and-mouth disease virus (FMDV) is a highly contagious and economically devastating pathogen that affects cloven-hoofed animals worldwide. FMDV infection causes vesicular lesions in the mouth, feet, and mammary glands, as well as severe systemic symptoms such as fever, salivation, and lameness. The pathogenesis of FMDV infection involves complex interactions between the virus and the host immune system, which determine the outcome of the disease. FMDV has evolved several strategies to evade immune recognition and elimination, such as antigenic variation, receptor switching, immune suppression, and subversion of innate and adaptive responses. This review paper summarizes the current knowledge on the pathogenesis of FMDV infection and the mechanisms of immune evasion employed by the virus. It also discusses the challenges and opportunities for developing effective vaccines and therapeutics against this important animal disease.</p>
</abstract>

Foot-and-mouth disease virus (FMDV) is a highly contagious and economically devastating pathogen that affects cloven-hoofed animals worldwide. FMDV infection causes vesicular lesions in the mouth, feet, and mammary glands, as well as severe systemic symptoms such as fever, salivation, and lameness. The pathogenesis of FMDV infection involves complex interactions between the virus and the host immune system, which determine the outcome of the disease. FMDV has evolved several strategies to evade immune recognition and elimination, such as antigenic variation, receptor switching, immune suppression, and subversion of innate and adaptive responses. This review paper summarizes the current knowledge on the pathogenesis of FMDV infection and the mechanisms of immune evasion employed by the virus. It also discusses the challenges and opportunities for developing effective vaccines and therapeutics against this important animal disease.

The Pathogenesis of Foot-and-Mouth Disease Virus Infection: How the Virus Escapes from Immune Recognition and Elimination

Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University Tandojam

Laboratory of Human Virology and Oncology, Center of Pathogen Biology and Immunology

Institute of Basic Medical Research, Shantou University Medical College

Research Institute of Clinical Pharmacy, Shantou University Medical College

Beijing University of Chinese Medicine Shenzhen Hospital

Shenzhen University General Hospital, Shenzhen University

Archivum Immunologiae et Therapiae Experimentalis

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Foot-and-mouth disease virus (FMDV) is a highly contagious and economically devastating pathogen that affects cloven-hoofed animals worldwide. FMDV infection...

The Pathogenesis of Foot-and-Mouth Disease Virus Infection: How the Virus Escapes from Immune Recognition and Elimination

Article Category: Review

Publié en ligne: 24 juin 2024

Pages: -

Reçu: 19 sept. 2023

Accepté: 22 avr. 2024

DOI: https://doi.org/10.2478/aite-2024-0013

Mots clés
Foot-and-mouth disease virus, Pathogenesis, Immune evasion, Vaccines, Therapeutics

© 2024 Abdul Kabir et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The Pathogenesis of Foot-and-Mouth Disease Virus Infection: How the Virus Escapes from Immune Recognition and Elimination

Article Category: Review

Publié en ligne: 24 juin 2024

Pages: -

Reçu: 19 sept. 2023

Accepté: 22 avr. 2024

DOI: https://doi.org/10.2478/aite-2024-0013

Mots clésFoot-and-mouth disease virus, Pathogenesis, Immune evasion, Vaccines, Therapeutics

© 2024 Abdul Kabir et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
Foot-and-mouth disease virus, Pathogenesis, Immune evasion, Vaccines, Therapeutics