Untying the anchor for the lipopolysaccharide: lipid A structural modification systems offer diagnostic and therapeutic options to tackle polymyxin resistance
et 
| 30 sept. 2023
| 30 sept. 2023
À propos de cet article
Article Category: Review
Publié en ligne: 30 sept. 2023
Pages: 145 - 166
Reçu: 01 janv. 2023
Accepté: 01 juil. 2023
DOI: https://doi.org/10.2478/aiht-2023-74-3717
© 2023 Vanessa Rogga et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Figure 1
A. baumannii native and modified lipid A structures and their corresponding m/z values (36, 39)
| Type | m/z | Proposed structure |
|---|---|---|
| Native lipid A | 1728 | |
| Native lipid A | 1910 | |
| Chromosome-encoded resistance – pEtN addition | 2033 (1910 + 123) | |
E. coli native and modified lipid A structures and their corresponding m/z value (38, 39, 44)
| Type | m/z | Proposed structure |
|---|---|---|
| Native lipid A | 1796 | |
| Chromosome-encoded resistance – L-Ara4N addition | 1927 (1796 + 131) | |
| Both plasmid- and chromosome-encoded resistance | 1919 (1796 + 123) | |
K. pneumoniae native and modified lipid A structures and their corresponding m/z values (35, 39)
| Type | m/z | Proposed structures |
|---|---|---|
| Native lipid A | 1824 | |
| 1840 | ||
| Native lipid A | 2062 | |
| 2078 | ||
| Chromosome-encoded resistance – L-Ara4N addition | 1971 (1840 + 131) | |
| 2209 (2078 + 131) | ||
| Plasmid-encoded resistance – pEtN addition | 1963 (1840 + 123) | |
| 2201 (2078 + 123) | ||
P. aeruginosa native and modified lipid A structures and their corresponding m/z values (37)
| Type | m/z | Proposed structures |
|---|---|---|
| Native lipid A | 1446 | |
| 1462 | ||
| Chromosome-encoded resistance – L-Ara4N addition | 1577 (1446 + 131) | |
| 1593 (1462 + 131) | ||
| 1708 (1446 + 262) | ||
| Chromosome-encoded resistance – L-Ara4N addition | 1724 (1462 + 262) | |
S. enterica native and modified lipid A structures and their corresponding m/z values (34, 39)
| Type | m/z | Proposed structure |
|---|---|---|
| Native lipid A | 1796 | |
| 1812 | ||
| Native lipid A | 1876 | |
| 2034 | ||
| Native lipid A | 2050 | |
| Chromosome-encoded resistance – L-Ara4N addition | 1927 (1796 + 131) | |
| Chromosome-encoded resistance – L-Ara4N addition | 2165 (2034 + 131) | |
| Plasmid-encoded resistance – pEtN addition | 1919 (1796 + 123) | |
| Plasmid-encoded resistance – pEtN addition | 1935 (1812 + 123) | |
| 2157 (2034 + 123) | ||
| Plasmid-encoded resistance – pEtN addition | 2173 (2050 + 123) | |