Redox and biometal status in Wistar rats after subacute exposure to fluoride and selenium counter-effects

1World Health Organization (WHO). Fluoride. In: Air quality guidelines for Europe. 2^nd ed. WHO regional publications, European series 91. Copenhagen: WHO Regional Office for Europe; 2000: p. 143–5. World Health Organization (WHO) Fluoride In Air quality guidelines for Europe. 2^nd ed. WHO regional publications, European series 91 Copenhagen WHO Regional Office for Europe 2000 p 143–5Search in Google Scholar

2World Health Organization (WHO). Fluorides and oral health: report of a WHO Expert Committee on Oral Health Status and Fluoride Use [meeting held in Geneva from 22 to 28 November 1993] [displayed 13 September 2022]. Available at https://apps.who.int/iris/handle/10665/39746 World Health Organization (WHO) Fluorides and oral health: report of a WHO Expert Committee on Oral Health Status and Fluoride Use [meeting held in Geneva from 22 to 28 November 1993] [displayed 13 September 2022] Available at https://apps.who.int/iris/handle/10665/39746Search in Google Scholar

3Aoun A, Darwiche F, Al Hayek S, Doumit J. The fluoride debate: The pros and cons of fluoridation. Prev Nutr Food Sci 2018;23:171–80. doi: 10.3746/pnf.2018.23.3.171 Aoun A Darwiche F Al Hayek S Doumit J The fluoride debate: The pros and cons of fluoridation Prev Nutr Food Sci 201823171 80 10.3746/pnf.2018.23.3.171Open DOISearch in Google Scholar

4O’Mullane DM, Baez RJ, Jones S, Lennon MA, Petersen PE, Rugg-Gunn AJ, Whelton H, Whitford GM. Fluoride and oral health. Community Dent Health 2016;33:69–99. PMID: 27352462 O’Mullane DM Baez RJ Jones S Lennon MA Petersen PE Rugg-Gunn AJ Whelton H Whitford GM Fluoride and oral health Community Dent Health 20163369 99 PMID: 27352462Search in Google Scholar

5Cape JN, Fowler D, Davison A. Ecological effects of sulfur dioxide, fluorides, and minor air pollutants: recent trends and research needs. Environ Int 2003;29:201–11. doi: 10.1016/s0160-4120(02)00180-0 Cape JN Fowler D Davison A Ecological effects of sulfur dioxide, fluorides, and minor air pollutants: recent trends and research needs Environ Int 200329201 11 10.1016/s0160-4120(02)00180-0Open DOISearch in Google Scholar

6Mondal P, Purkait MK. Preparation and characterization of novel green synthesized iron-aluminum nanocomposite and studying its efficiency in fluoride removal. Chemosphere 2019;235:391–402. doi: 10.1016/j.chemosphere.2019.06.189 Mondal P Purkait MK Preparation and characterization of novel green synthesized iron-aluminum nanocomposite and studying its efficiency in fluoride removal Chemosphere 2019235391 402 10.1016/j.chemosphere.2019.06.18931271999Open DOISearch in Google Scholar

7Haldar D, Duarah P, Purkait MK. MOFs for the treatment of arsenic, fluoride and iron contaminated drinking water: A review. Chemosphere 2020;251:126388. doi: 10.1016/j.chemosphere.2020.126388 Haldar D Duarah P Purkait MK MOFs for the treatment of arsenic, fluoride and iron contaminated drinking water: A review Chemosphere 2020251126388 10.1016/j.chemosphere.2020.12638832443223Open DOISearch in Google Scholar

8Kumar M, Goswami R, Patel AK, Srivastava M, Das N. Scenario, perspectives and mechanism of arsenic and fluoride Co-occurrence in the groundwater: A review. Chemosphere 2020;249:126126. doi: 10.1016/j.chemosphere.2020.126126 Kumar M Goswami R Patel AK Srivastava M Das N Scenario, perspectives and mechanism of arsenic and fluoride Co-occurrence in the groundwater: A review Chemosphere 2020249126126 10.1016/j.chemosphere.2020.12612632142984Open DOISearch in Google Scholar

9Kashyap SJ, Sankannavar R, Madhu GM. Fluoride sources, toxicity and fluorosis management techniques - A brief review. J Hazard Mat Lett 2021;2:100033. doi: 10.1016/j.hazl.2021.100033 Kashyap SJ Sankannavar R Madhu GM Fluoride sources, toxicity and fluorosis management techniques - A brief review J Hazard Mat Lett 20212100033 10.1016/j.hazl.2021.100033Open DOISearch in Google Scholar

10Vithanage M, Bhattacharya P. Fluoride in the environment: sources, distribution and defluoridation. Environ Chem Lett 2015;13:131–47. doi: 10.1007/s10311-015-0496-4 Vithanage M Bhattacharya P Fluoride in the environment: sources, distribution and defluoridation Environ Chem Lett 201513131 47 10.1007/s10311-015-0496-4Open DOISearch in Google Scholar

11Chowdhury A, Adak MK, Mukherjee A, Dhak P, Khatun J, Dhak D. A critical review on geochemical and geological aspects of fluoride belts, fluorosis and natural materials and other sources for alternatives to fluoride exposure. J Hydrology 2019;574:333–59. doi: 10.1016/j. jhydrol.2019.04.033 Chowdhury A Adak MK Mukherjee A Dhak P Khatun J Dhak D A critical review on geochemical and geological aspects of fluoride belts, fluorosis and natural materials and other sources for alternatives to fluoride exposure J Hydrology 2019574333 59 10.1016/j.jhydrol.2019.04.033Open DOISearch in Google Scholar

12Vandana K, Raj BS, Desai R. Dental fluorosis and periodontium: an original research report of in vitro and in vivo institutional studies. Biol Trace Elem Res 2021;199:3579–92. doi: 10.1007/s12011-020-02494-0 Vandana K Raj BS Desai R Dental fluorosis and periodontium: an original research report of in vitro and in vivo institutional studies Biol Trace Elem Res 20211993579 92 10.1007/s12011-020-02494-033405081Open DOISearch in Google Scholar

13Mondal P, Chattopadhyay A. Environmental exposure of arsenic and fluoride and their combined toxicity: a recent update. J Appl Toxicol 2020;40:552–66. doi: 10.1002/jat.3931 Mondal P Chattopadhyay A Environmental exposure of arsenic and fluoride and their combined toxicity: a recent update J Appl Toxicol 202040552 66 10.1002/jat.393131867774Open DOISearch in Google Scholar

14Fu R, Niu R, Zhao F, Wang J, Cao Q, Yu Y, Liu C, Zhang D, Sun Z. Exercise alleviated intestinal damage and microbial disturbances in mice exposed to fluoride. Chemosphere 2022;288:132658. doi: 10.1016/j.chemosphere.2021.132658 Fu R Niu R Zhao F Wang J Cao Q Yu Y Liu C Zhang D Sun Z Exercise alleviated intestinal damage and microbial disturbances in mice exposed to fluoride Chemosphere 2022288132658 10.1016/j.chemosphere.2021.13265834710452Open DOISearch in Google Scholar

15Srivastava S, Flora SJS. Fluoride in drinking water and skeletal fluorosis: a review of the global impact. Curr Environ Health Rep 2020;7:140–6. doi: 10.1007/s40572-020-00270-9 Srivastava S Flora SJS Fluoride in drinking water and skeletal fluorosis: a review of the global impact Curr Environ Health Rep 20207140 6 10.1007/s40572-020-00270-932207100Open DOISearch in Google Scholar

16Skórka-Majewicz M, Goschorska M, Żwierełło W, Baranowska-Bosiacka I, Styburski D, Kapczuk P, Gutowska I. Effect of fluoride on endocrine tissues and their secretory functions-review. Chemosphere 2020;260:127565. doi: 10.1016/j.chemosphere.2020.127565 p. 127565 Skórka-Majewicz M Goschorska M Żwierełło W Baranowska-Bosiacka I Styburski D Kapczuk P Gutowska I Effect of fluoride on endocrine tissues and their secretory functions-review Chemosphere 2020260127565 10.1016/j.chemosphere.2020.127565p.127565Open DOISearch in Google Scholar

17Lima LADO, Miranda GHN, Aragão WAB, Bittencourt LO, dos Santos SM, de Souza MPC, Nogueira LS, de Oliveira EHC, Monteiro MC, Dionizio A, Leite AL, Pessan JP, Buzalaf MAR, Lima RR. Effects of fluoride on submandibular glands of mice: changes in oxidative biochemistry, proteomic profile, and genotoxicity. Front Pharmacol 2021;12:715394. doi: 10.3389/fphar.2021.715394 Lima LADO Miranda GHN Aragão WAB Bittencourt LO dos Santos SM de Souza MPC Nogueira LS de Oliveira EHC Monteiro MC Dionizio A Leite AL Pessan JP Buzalaf MAR Lima RR Effects of fluoride on submandibular glands of mice: changes in oxidative biochemistry, proteomic profile, and genotoxicity Front Pharmacol 202112715394 10.3389/fphar.2021.715394850326134646132Open DOISearch in Google Scholar

18Li H, Fan J, Zhao Y, Yang J, Xu H, Manthari RK, Cheng X, Wang J, Wang J. Calcium alleviates fluoride-induced kidney damage via FAS/ FASL, TNFR/TNF, DR5/TRAIL pathways in rats. Ecotoxicol Environ Saf 2021;226:112851. doi: 10.1016/j.ecoenv.2021.112851 Li H Fan J Zhao Y Yang J Xu H Manthari RK Cheng X Wang J Wang J Calcium alleviates fluoride-induced kidney damage via FAS/ FASL, TNFR/TNF, DR5/TRAIL pathways in rats Ecotoxicol Environ Saf 2021226112851 10.1016/j.ecoenv.2021.11285134619480Open DOISearch in Google Scholar

19Barbier O, Arreola-Mendoza L, del Razo LM. Molecular mechanisms of fluoride toxicity. Chem Biol Interact 2010;188:319–33. doi: 10.1016/j.cbi.2010.07.011 Barbier O Arreola-Mendoza L del Razo LM Molecular mechanisms of fluoride toxicity Chem Biol Interact 2010188319 33 10.1016/j.cbi.2010.07.01120650267Open DOISearch in Google Scholar

20Korkmaz R, Yüksek V, Dede S. The effects of sodium fluoride (NaF) treatment on the PI3K/Akt signal pathway in NRK-52E cells. Biol Trace Elem Res 2022;200:3294–302. doi: 10.1007/s12011-021-02927-4 Korkmaz R Yüksek V Dede S The effects of sodium fluoride (NaF) treatment on the PI3K/Akt signal pathway in NRK-52E cells Biol Trace Elem Res 20222003294 302 10.1007/s12011-021-02927-434569011Open DOISearch in Google Scholar

21Angwa LM, Jiang Y, Pei J, Sun D. Antioxidant phytochemicals for the prevention of fluoride-induced oxidative stress and apoptosis: a review. 2022;200:1418–41. doi: 10.1007/s12011-021-02729-8 Angwa LM Jiang Y Pei J Sun D Antioxidant phytochemicals for the prevention of fluoride-induced oxidative stress and apoptosis: a review 20222001418 41 10.1007/s12011-021-02729-834003450Open DOISearch in Google Scholar

22Efe U, Dede S, Yüksek V, Çetin S. Apoptotic and oxidative mechanisms in liver and kidney tissues of sheep with fluorosis. Biol Trace Elem Res 2021;199:136–41. doi: 10.1007/s12011-020-02121-y Efe U Dede S Yüksek V Çetin S Apoptotic and oxidative mechanisms in liver and kidney tissues of sheep with fluorosis Biol Trace Elem Res 2021199136 41 10.1007/s12011-020-02121-y32277396Open DOISearch in Google Scholar

23Strunecka A, Strunecky O. Mechanisms of fluoride toxicity: from enzymes to underlying integrative networks. Appl Sci 2020;10(20):7100. doi: 10.3390/app10207100 Strunecka A Strunecky O Mechanisms of fluoride toxicity: from enzymes to underlying integrative networks Appl Sci 202010207100 10.3390/app10207100Open DOISearch in Google Scholar

24Radovanovic J, Banjac K, Obradovic M, Isenovic ER. Antioxidant enzymes and vascular diseases. Explor Med 2021;2:544–55. doi: 10.37349/emed.2021.00070 Radovanovic J Banjac K Obradovic M Isenovic ER Antioxidant enzymes and vascular diseases Explor Med 20212544 55 10.37349/emed.2021.00070Open DOISearch in Google Scholar

25Maheshwari N, Qasim N, Anjum R, Mahmood R. Fluoride enhances generation of reactive oxygen and nitrogen species, oxidizes hemoglobin, lowers antioxidant power and inhibits transmembrane electron transport in isolated human red blood cells. Ecotoxicol Environ Saf 2021;208:111611. doi: 10.1016/j.ecoenv.2020.111611 Maheshwari N Qasim N Anjum R Mahmood R Fluoride enhances generation of reactive oxygen and nitrogen species, oxidizes hemoglobin, lowers antioxidant power and inhibits transmembrane electron transport in isolated human red blood cells Ecotoxicol Environ Saf 2021208111611 10.1016/j.ecoenv.2020.11161133396131Open DOISearch in Google Scholar

26Wang H-W, Zhao W-P, Liu J, Tan P-P, Zhang C, Zhou B-H. Fluoride-induced oxidative stress and apoptosis are involved in the reducing of oocytes development potential in mice. Chemosphere 2017;186:911–8. doi: 10.1016/j.chemosphere.2017.08.068 Wang H-W Zhao W-P Liu J Tan P-P Zhang C Zhou B-H Fluoride-induced oxidative stress and apoptosis are involved in the reducing of oocytes development potential in mice Chemosphere 2017186911–8 10.1016/j.chemosphere.2017.08.06828826138Open DOISearch in Google Scholar

27Mondal P, Shaw P, Dey Bhowmik A, Bandyopadhyay A, Sudarshan M, Chakraborty A, Chattopadhyay A. Combined effect of arsenic and fluoride at environmentally relevant concentrations in zebrafish (Danio rerio) brain: Alterations in stress marker and apoptotic gene expression. Chemosphere 2021;269:128678. doi: 10.1016/j.chemosphere.2020.128678 Mondal P Shaw P Dey Bhowmik A Bandyopadhyay A Sudarshan M Chakraborty A Chattopadhyay A Combined effect of arsenic and fluoride at environmentally relevant concentrations in zebrafish (Danio rerio) brain: Alterations in stress marker and apoptotic gene expression Chemosphere 2021269128678 10.1016/j.chemosphere.2020.12867833127104Open DOISearch in Google Scholar

28Ma Y, Ma Z, Yin S, Yan X, Wang J. Arsenic and fluoride induce apoptosis, inflammation and oxidative stress in cultured human umbilical vein endothelial cells. Chemosphere 2017;167:454–61. doi: 10.1016/j.chemosphere.2016.10.025 Ma Y Ma Z Yin S Yan X Wang J Arsenic and fluoride induce apoptosis, inflammation and oxidative stress in cultured human umbilical vein endothelial cells Chemosphere 2017167454 61 10.1016/j.chemosphere.2016.10.02527750169Open DOISearch in Google Scholar

29Li M, Cao J, Zhao Y, Wu P, Li X, Khodaei F, Han Y, Wang J. Fluoride impairs ovary development by affecting oogenesis and inducing oxidative stress and apoptosis in female zebrafish (Danio rerio). Chemosphere 2020;256:127105. do i: 10.1016/j.chemosphere.2020.127105 Li M Cao J Zhao Y Wu P Li X Khodaei F Han Y Wang J Fluoride impairs ovary development by affecting oogenesis and inducing oxidative stress and apoptosis in female zebrafish (Danio rerio) Chemosphere 2020256127105 10.1016/j.chemosphere.2020.12710510.1016/j.chemosphere.2020.12710532450357Search in Google Scholar

30Guo Q, Sun Z, Niu R, Manthari RK, Yuan M, Yang K, Cheng M, Gong Z, Wang J. Effect of arsenic and/ or fluoride gestational exposure on renal autophagy in offspring mice. Chemosphere 2020;241:124861. doi: 10.1016/j.chemosphere.2019.124861 Guo Q Sun Z Niu R Manthari RK Yuan M Yang K Cheng M Gong Z Wang J Effect of arsenic and/ or fluoride gestational exposure on renal autophagy in offspring mice Chemosphere 2020241124861 10.1016/j.chemosphere.2019.12486131605998Open DOISearch in Google Scholar

31Kheradpisheh Z, Mirzaei M, Mahvi AH, Mokhtari M, Azizi R, Fallahzadeh H, Ehrampoush MH. Impact of drinking water fluoride on human thyroid hormones: a case-control study. Sci Rep 2018;8(1):2674. doi: 10.1038/s41598-018-20696-4 Kheradpisheh Z Mirzaei M Mahvi AH Mokhtari M Azizi R Fallahzadeh H Ehrampoush MH Impact of drinking water fluoride on human thyroid hormones: a case-control study Sci Rep 2018812674 10.1038/s41598-018-20696-4580568129422493Open DOISearch in Google Scholar

32Radovanović J, Antonijević B, Kolarević S, Milutinović-Smiljanić S, Mandić J, Vuković-Gačić B, Bulat Z, Ćurčić M, Kračun-Kolarević M, Sunjog K, Kostić-Vuković J, Marić JJ, Antonijević-Miljaković E, Đukić-Ćosić D, Djordjevic AB, Javorac D, Baralić K, Mandinić Z. Genotoxicity of fluoride subacute exposure in rats and selenium intervention. Chemosphere 2021;266:128978. doi: 10.1016/j. chemosphere.2020.128978 Radovanović J Antonijević B Kolarević S Milutinović-Smiljanić S Mandić J Vuković-Gačić B Bulat Z Ćurčić M Kračun-Kolarević M Sunjog K Kostić-Vuković J Marić JJ Antonijević-Miljaković E Đukić-Ćosić D Djordjevic AB Javorac D Baralić K Mandinić Z Genotoxicity of fluoride subacute exposure in rats and selenium intervention Chemosphere 2021266128978 10.1016/j.chemosphere.2020.12897833298328Open DOISearch in Google Scholar

33Nieder R, Benbi DK, Reichl FX. Microelements and their role in human health. In: Soil components and human health. Chapter 7. Dordrecht: Springer; 2018. p. 317–74. Nieder R Benbi DK Reichl FX Microelements and their role in human health. In Soil components and human health. Chapter 7 Dordrecht Springer 2018 p 317–7410.1007/978-94-024-1222-2Search in Google Scholar

34Dec K, Łukomska A, Skonieczna-Żydecka K, Jakubczyk K, Tarnowski M, Lubkowska A, Baranowska-Bosiacka I, Styburski D, Skórka-Majewicz M, Maciejewska D, Gutowska I. Chronic exposure to fluoride affects GSH level and NOX4 expression in rat model of this element of neurotoxicity. Biomolecules 2020;10(3):422. doi: 10.3390/ biom10030422 Dec K Łukomska A Skonieczna-Żydecka K Jakubczyk K Tarnowski M Lubkowska A Baranowska-Bosiacka I Styburski D Skórka-Majewicz M Maciejewska D Gutowska I Chronic exposure to fluoride affects GSH level and NOX4 expression in rat model of this element of neurotoxicity Biomolecules 2020103422 10.3390/biom10030422Open DOISearch in Google Scholar

35Ames B. DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mut Res 2001;475:7–20. doi: 10.1016/S0027-5107(01)00070-7 Ames B DNA damage from micronutrient deficiencies is likely to be a major cause of cancer Mut Res 20014757 20 10.1016/S0027-5107(01)00070-7Open DOISearch in Google Scholar

36Shenkin A. Micronutrients in health and disease. Postgrad Med J 2006;82:559–67. doi: 10.1136/pgmj.2006.047670 Shenkin A Micronutrients in health and disease Postgrad Med J 200682559 67 10.1136/pgmj.2006.047670Open DOISearch in Google Scholar

37Mazurek-Mochol M. [Interaction between fluorine and zinc after long-term oral administration into the digestive system of rats, in Polish]. Ann Acad Med Stetin 2002;48:75–83. PMID: 14601470 Mazurek-Mochol M [Interaction between fluorine and zinc after long-term oral administration into the digestive system of rats, in Polish] Ann Acad Med Stetin 20024875 83 PMID: 14601470Search in Google Scholar

38Mou S, Qin S, Hu Q, Duan X. [Effect of fluorine, selenium and cadmium on anti-oxidase and microelements in rat’s body, in Chinese]. Wei Sheng Yan Jiu 2004;33:211–3. PMID: 15209009 Mou S Qin S Hu Q Duan X [Effect of fluorine, selenium and cadmium on anti-oxidase and microelements in rat’s body, in Chinese] Wei Sheng Yan Jiu 200433211 3 PMID: 15209009Search in Google Scholar

39Karademir B. Effect of fluoride ingestion on serum levels of the trace minerals Co, Mo, Cr, Mn and Li in adult male mice. Fluoride 2010;43:174–8. Karademir B Effect of fluoride ingestion on serum levels of the trace minerals Co, Mo, Cr, Mn and Li in adult male mice Fluoride 201043174 8Search in Google Scholar

40Rayman MP. The importance of selenium to human health. Lancet 2000;356:233–41. doi: 10.1016/s0140-6736(00)02490-9 Rayman MP The importance of selenium to human health Lancet 2000356233 41 10.1016/s0140-6736(00)02490-9Open DOISearch in Google Scholar

41Yin K, Cui Y, Sun T, Qi X, Zhang Y, Lin H. Antagonistic effect of selenium on lead-induced neutrophil apoptosis in chickens via miR-16-5p targeting of PiK3R1 and IGF1R. Chemosphere 2020;246:125794. doi: 10.1016/j.chemosphere.2019.125794 Yin K Cui Y Sun T Qi X Zhang Y Lin H Antagonistic effect of selenium on lead-induced neutrophil apoptosis in chickens via miR-16-5p targeting of PiK3R1 and IGF1R Chemosphere 2020246125794 10.1016/j.chemosphere.2019.12579431918102Open DOISearch in Google Scholar

42Zwolak I. The role of selenium in arsenic and cadmium toxicity: an updated review of scientific literature. Biol Trace Elem Res 2020;193:44–63. doi: 10.1007/s12011-019-01691-w Zwolak I The role of selenium in arsenic and cadmium toxicity: an updated review of scientific literature Biol Trace Elem Res 202019344 63 10.1007/s12011-019-01691-w691471930877523Open DOISearch in Google Scholar

43Wai KM, Umezaki M, Umemura M, Mar O, Watanabe C. Protective role of selenium in the shortening of telomere length in newborns induced by in utero heavy metal exposure. Environ Res 2020;183:109202. doi: 10.1016/j.envres.2020.109202 Wai KM Umezaki M Umemura M Mar O Watanabe C Protective role of selenium in the shortening of telomere length in newborns induced by in utero heavy metal exposure Environ Res 2020183109202 10.1016/j.envres.2020.10920232045728Open DOISearch in Google Scholar

44Yüksek V, Çetin S, Usta A. The effect of vitamin E and selenium combination in repairing fluoride-induced DNA damage to NRK-52E cells. Mol Biol Rep 2020;47:7761–70. doi: 10.1007/s11033-020-05852-2 Yüksek V Çetin S Usta A The effect of vitamin E and selenium combination in repairing fluoride-induced DNA damage to NRK-52E cells Mol Biol Rep 2020477761 70 10.1007/s11033-020-05852-233025505Open DOISearch in Google Scholar

45Charitha G, Sudhakar K, Reddy K. Protective effects of selenium against sodium fluoride induced behavioral, anti-oxidant and neurohistological alterations in wistar rats. Biosci Biotechnol Res Asia 2018;15:475–84. doi: 10.13005/bbra/2652 Charitha G Sudhakar K Reddy K Protective effects of selenium against sodium fluoride induced behavioral, anti-oxidant and neurohistological alterations in wistar rats Biosci Biotechnol Res Asia 201815475 84 10.13005/bbra/2652Open DOISearch in Google Scholar

46Hubrecht RC, Carter E. The 3Rs and humane experimental technique: implementing change. Animals 2019;9(10):754. doi: 10.3390/ ani9100754 Hubrecht RC Carter E The 3Rs and humane experimental technique: implementing change Animals 2019910754 10.3390/ani9100754682693031575048Open DOISearch in Google Scholar

47Sharma D, Singh A, Verma K, Paliwal S, Sharma S, Dwivedi J. Fluoride: A review of pre-clinical and clinical studies. Environ Toxicol Pharmacol 2017;56:297–313. doi: 10.1016/j.etap.2017.10.008 Sharma D Singh A Verma K Paliwal S Sharma S Dwivedi J Fluoride: A review of pre-clinical and clinical studies Environ Toxicol Pharmacol 201756297 313 10.1016/j.etap.2017.10.008Open DOISearch in Google Scholar

48Jain RB. Concentrations of fluoride in water and plasma for US children and adolescents: Data from NHANES 2013–2014. Environ Toxicol Pharmacol 2017;50:20–31. doi: 10.1016/j.etap.2017.01.006 Jain RB Concentrations of fluoride in water and plasma for US children and adolescents: Data from NHANES 2013–2014 Environ Toxicol Pharmacol 20175020 31 10.1016/j.etap.2017.01.006Open DOISearch in Google Scholar

49Feng P, Wei J, Zhang Z. Intervention of selenium on chronic fluorosis-induced injury of blood antioxidant capacity in rats. Biol Trace Elem Res 2011;144:1024–31. doi: 10.1007/s12011-011-9087-9 Feng P Wei J Zhang Z Intervention of selenium on chronic fluorosis-induced injury of blood antioxidant capacity in rats Biol Trace Elem Res 20111441024 31 10.1007/s12011-011-9087-9Open DOISearch in Google Scholar

50Yang SY, Zhang L, Miao KK, Qian W, Zhang ZG. Effects of selenium intervention on chronic fluorosis-induced renal cell apoptosis in rats. Biol Trace Elem Res 2013;153:237–42. doi: 10.1007/s12011-013-9649-0 Yang SY Zhang L Miao KK Qian W Zhang ZG Effects of selenium intervention on chronic fluorosis-induced renal cell apoptosis in rats Biol Trace Elem Res 2013153237 42 10.1007/s12011-013-9649-0Open DOISearch in Google Scholar

51Miao K, Zhang L, Yang S, Qian W, Zhang Z. Intervention of selenium on apoptosis and Fas/FasL expressions in the liver of fluoride-exposed rats. Environ Toxicol Pharmacol 2013;36:913–20. doi: 10.1016/j. etap.2013.08.003 Miao K Zhang L Yang S Qian W Zhang Z Intervention of selenium on apoptosis and Fas/FasL expressions in the liver of fluoride-exposed rats Environ Toxicol Pharmacol 201336913 20 10.1016/j.etap.2013.08.003Open DOISearch in Google Scholar

52Mandinic Z. Effect of Fluoride on Oxidative Stress Parameters in Experimental Animals. [PhD thesis]. Belgrade: School of Dentistry, University of Belgrade; 2011. Mandinic Z Effect of Fluoride on Oxidative Stress Parameters in Experimental Animals. [PhD thesis] Belgrade School of Dentistry, University of Belgrade; 2011Search in Google Scholar

53Mandinic Z, Carevic M, Curcic M, Antonijevic B, Jacevic V. Serum changes of MDA in fluoride intoxicated rats. In: 17^th Congress of BaSS; 3–6 May 2012.; Tirana, Albania 2012. Abstract book 2012. p. 125. Mandinic Z Carevic M Curcic M Antonijevic B Jacevic V Serum changes of MDA in fluoride intoxicated rats In 17^th Congress of BaSS; 3–6 May 2012 Tirana, Albania 2012 Abstract book 2012. p. 125Search in Google Scholar

54Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes ˙(Text with EEA relevance) [displayed 13 September 2022]. Available at https://eur-lex.europa.eu/eli/dir/2010/63/2019-06-26 Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes ˙(Text with EEA relevance) [displayed 13 September 2022] Available at https://eur-lex.europa.eu/eli/dir/2010/63/2019-06-26Search in Google Scholar

55Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248–54. doi: 10.1006/abio.1976.9999 Bradford MM A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 197672248 54 10.1006/abio.1976.9999Open DOISearch in Google Scholar

56Auclair C. Nitroblue tetrazolium reduction. In: Greenwald RA, editor. Handbook of methods for oxygen radicals research. Boca Raton: CRC Press; 1988 p. 123–32. Auclair C Nitroblue tetrazolium reduction In Greenwald RA editor Handbook of methods for oxygen radicals research Boca Raton CRC Press 1988 p 123–32Search in Google Scholar

57Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005;38:1103–11. doi: 10.1016/j. clinbiochem.2005.08.008 Erel O A new automated colorimetric method for measuring total oxidant status Clin Biochem 2005381103 11 10.1016/j.clinbiochem.2005.08.008Open DOISearch in Google Scholar

58Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972;247:3170–5. PMID: 4623845 Misra HP Fridovich I The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase J Biol Chem 19722473170 5 PMID: 462384510.1016/S0021-9258(19)45228-9Search in Google Scholar

59Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959;82:70–7. doi: 10.1016/0003-9861(59)90090-6 Ellman GL Tissue sulfhydryl groups Arch Biochem Biophys 19598270 7 10.1016/0003-9861(59)90090-6Open DOISearch in Google Scholar

60Girotti MJ, Khan N, McLellan BA. Early measurement of systemic lipid peroxidation products in the plasma of major blunt trauma patients. J Trauma 1991;31:32–5. doi: 10.1097/00005373-199101000-00007 Girotti MJ Khan N McLellan BA Early measurement of systemic lipid peroxidation products in the plasma of major blunt trauma patients J Trauma 19913132 5 10.1097/00005373-199101000-000071846013Open DOISearch in Google Scholar

61Nedeljković M, Antonijević B, Matović V. Simplified sample preparation for fluoride determination in biological material. Analyst 1991;116:477–8. doi: 10.1039/an9911600477 Nedeljković M Antonijević B Matović V Simplified sample preparation for fluoride determination in biological material Analyst 1991116477 8 10.1039/an99116004771877753Open DOISearch in Google Scholar

62Pereira M, Dombrowski PA, Losso EM, Chioca LR, Da Cunha C, Andreatini R. Memory impairment induced by sodium fluoride is associated with changes in brain monoamine levels. Neurotox Res 2011;19:55–62. doi: 10.1007/s12640-009-9139-5 Pereira M Dombrowski PA Losso EM Chioca LR Da Cunha C Andreatini R Memory impairment induced by sodium fluoride is associated with changes in brain monoamine levels Neurotox Res 20111955 62 10.1007/s12640-009-9139-519957215Open DOISearch in Google Scholar

63Chioca LR, Raupp IM, Da Cunha C, Losso EM, Andreatini R. Subchronic fluoride intake induces impairment in habituation and active avoidance tasks in rats. Eur J Pharmacol 2008;579:196–201. doi: 10.1016/j.ejphar.2007.10.019 Chioca LR Raupp IM Da Cunha C Losso EM Andreatini R Subchronic fluoride intake induces impairment in habituation and active avoidance tasks in rats Eur J Pharmacol 2008579196 201 10.1016/j.ejphar.2007.10.01918001709Open DOISearch in Google Scholar

64Perera T, Ranasinghe S, Alles N, Waduge R. Effect of fluoride on major organs with the different time of exposure in rats. Environ Health Prev Med 2018;23:17. doi: 10.1186/s12199-018-0707-2 Perera T Ranasinghe S Alles N Waduge R Effect of fluoride on major organs with the different time of exposure in rats Environ Health Prev Med 20182317 10.1186/s12199-018-0707-2595692329769014Open DOISearch in Google Scholar

65Amaral SL, Azevedo LB, Buzalaf MAR, Fabricio MF, Fernandes MS, Valentine RA, Maguire A, Zohoor FV. Effect of chronic exercise on fluoride metabolism in fluorosis-susceptible mice exposed to high fluoride. Sci Rep 2018;8:3211. doi: 10.1038/s41598-018-21616-2 Amaral SL Azevedo LB Buzalaf MAR Fabricio MF Fernandes MS Valentine RA Maguire A Zohoor FV Effect of chronic exercise on fluoride metabolism in fluorosis-susceptible mice exposed to high fluoride Sci Rep 201883211 10.1038/s41598-018-21616-2581664329453343Open DOISearch in Google Scholar

66Balaha M, Ahmed N, Geddawy A, Kandeel S. Fraxetin prevented sodium fluoride-induced chronic pancreatitis in rats: Role of anti-inflammatory, antioxidant, antifibrotic and anti-apoptotic activities. Int Immunopharmacol 2021;93:107372. doi: 10.1016/j. intimp.2021.107372 Balaha M Ahmed N Geddawy A Kandeel S Fraxetin prevented sodium fluoride-induced chronic pancreatitis in rats: Role of anti-inflammatory, antioxidant, antifibrotic and anti-apoptotic activities Int Immunopharmacol 202193107372 10.1016/j.intimp.2021.10737233524802Open DOISearch in Google Scholar

67Sieber F, Muir SA, Cohen EP, Fish BL, Mäder M, Schock AM, Althouse BJ, Moulder JE. Dietary selenium for the mitigation of radiation injury: effects of selenium dose escalation and timing of supplementation. Radiat Res 2011;176:366–74. doi: 10.1667/rr2456.1 Sieber F Muir SA Cohen EP Fish BL Mäder M Schock AM Althouse BJ Moulder JE Dietary selenium for the mitigation of radiation injury: effects of selenium dose escalation and timing of supplementation Radiat Res 2011176366 74 10.1667/rr2456.1323794521867430Open DOISearch in Google Scholar

68Crespo AM, Neve J, Pinto RE. Plasma and liver selenium levels in the rat during supplementation with 0.5, 2, 6, and 15 ppm selenium in drinking water. Biol Trace Elem Res 1993;38:139–47. doi: 10.1007/ bf02784050 Crespo AM Neve J Pinto RE Plasma and liver selenium levels in the rat during supplementation with 0.5, 2, 6, and 15 ppm selenium in drinking water Biol Trace Elem Res 199338139 47 10.1007/bf02784050Open DOISearch in Google Scholar

69Miranda GHN, Gomes BAQ, Bittencourt LO, Aragao WAB, Nogueira LS, Dionizio AS, Buzalaf MAR, Monteiro MC, Lima RR. Chronic exposure to sodium fluoride triggers oxidative biochemistry misbalance in mice: effects on peripheral blood circulation. Oxid Med Cell Longev 2018;2018:8379123. doi: 10.1155/2018/8379123 Miranda GHN Gomes BAQ Bittencourt LO Aragao WAB Nogueira LS Dionizio AS Buzalaf MAR Monteiro MC Lima RR Chronic exposure to sodium fluoride triggers oxidative biochemistry misbalance in mice: effects on peripheral blood circulation Oxid Med Cell Longev 201820188379123 10.1155/2018/8379123612979430224946Open DOISearch in Google Scholar

70Tkachenko H, Kurhaluk N, Skaletska N, Maksin V, Osadowski Z. Elemental status and lipid peroxidation in the blood of children with endemic fluorosis. Biol Trace Elem Res 2021;199:1237–45. doi: 10.1007/s12011-020-02243-3 Tkachenko H Kurhaluk N Skaletska N Maksin V Osadowski Z Elemental status and lipid peroxidation in the blood of children with endemic fluorosis Biol Trace Elem Res 20211991237 45 10.1007/s12011-020-02243-3788673632557098Open DOISearch in Google Scholar

71Ferreira MKM, Aragão WAB, Bittencourt LO, Puty B, Dionizio A, Souza MPC, Buzalaf MAR, de Oliveira EH, Crespo-Lopez ME, Lima RR. Fluoride exposure during pregnancy and lactation triggers oxidative stress and molecular changes in hippocampus of offspring rats. Ecotoxicol Environ Saf 2021;208:111437. doi: 10.1016/j. ecoenv.2020.111437 Ferreira MKM Aragão WAB Bittencourt LO Puty B Dionizio A Souza MPC Buzalaf MAR de Oliveira EH Crespo-Lopez ME Lima RR Fluoride exposure during pregnancy and lactation triggers oxidative stress and molecular changes in hippocampus of offspring rats Ecotoxicol Environ Saf 2021208111437 10.1016/j.ecoenv.2020.11143733096359Open DOISearch in Google Scholar

72Oyagbemi AA, Adejumobi OA, Jarikre TA, Ajani OS, Asenuga ER, Gbadamosi IT, Adedapo ADA, Aro AO, Ogunpolu BS, Hassan FO, Falayi OO, Ogunmiluyi IO, Omobowale TO, Arojojoye OA, Ola-Davies OE, Saba AB, Adedapo AA, Emikpe BO, Oyeyemi MO, Nkadimeng SM, McGaw LJ, Kayoka-Kabongo PN, Oguntibeju OO, Yakubu MA. Clofibrate, a peroxisome proliferator-activated receptor-alpha (PPARα) agonist, and its molecular mechanisms of action against sodium fluoride-induced toxicity. Biol Trace Elem Res 2022;200:1220–36. doi: 10.1007/s12011-021-02722-1 Oyagbemi AA Adejumobi OA Jarikre TA Ajani OS Asenuga ER Gbadamosi IT Adedapo ADA Aro AO Ogunpolu BS Hassan FO Falayi OO Ogunmiluyi IO Omobowale TO Arojojoye OA Ola-Davies OE Saba AB Adedapo AA Emikpe BO Oyeyemi MO Nkadimeng SM McGaw LJ Kayoka-Kabongo PN Oguntibeju OO Yakubu MA Clofibrate, a peroxisome proliferator-activated receptor-alpha (PPARα) agonist, and its molecular mechanisms of action against sodium fluoride-induced toxicity Biol Trace Elem Res 20222001220–36 10.1007/s12011-021-02722-133893992Open DOISearch in Google Scholar

73Zhang J, Song J, Zhang J, Chen X, Zhou M, Cheng G, Xie X. Combined effects of fluoride and cadmium on liver and kidney function in male rats. Biol Trace Elem Res 2013;155:396–402. doi: 10.1007/s12011-013-9807-4 Zhang J Song J Zhang J Chen X Zhou M Cheng G Xie X Combined effects of fluoride and cadmium on liver and kidney function in male rats Biol Trace Elem Res 2013155396 402 10.1007/s12011-013-9807-424006106Open DOISearch in Google Scholar

74Błaszczyk I, Grucka-Mamczar E, Kasperczyk S, Birkner E. Influence of fluoride on rat kidney antioxidant system: effects of methionine and vitamin E. Biol Trace Elem Res 2008;121:51–9. doi: 10.1007/ s12011-007-8030-6 Błaszczyk I Grucka-Mamczar E Kasperczyk S Birkner E Influence of fluoride on rat kidney antioxidant system: effects of methionine and vitamin E Biol Trace Elem Res 200812151 9 10.1007/s12011-007-8030-618186000Open DOISearch in Google Scholar

75Li H, Hao Z, Wang L, Yang J, Zhao Y, Cheng X, Yuan H, Wang J. Dietary calcium alleviates fluorine-induced liver injury in rats by mitochondrial apoptosis pathway. Biol Trace Elem Res 2022;200:271–80. doi: 10.1007/s12011-021-02641-1 Li H Hao Z Wang L Yang J Zhao Y Cheng X Yuan H Wang J Dietary calcium alleviates fluorine-induced liver injury in rats by mitochondrial apoptosis pathway Biol Trace Elem Res 2022200271–80 10.1007/s12011-021-02641-133629228Open DOISearch in Google Scholar

76Manieri TM, Sensi SL, Squitti R, Cerchiaro G. Structural effects of stabilization and complexation of a zinc-deficient superoxide dismutase. Heliyon 2021;7(1):e06100. doi: 10.1016/j.heliyon.2021. e06100 Manieri TM Sensi SL Squitti R Cerchiaro G Structural effects of stabilization and complexation of a zinc-deficient superoxide dismutase Heliyon 202171e06100 10.1016/j.heliyon.2021.e06100784863733553758Open DOISearch in Google Scholar

77Shuhua X, Ziyou L, Ling Y, Fei W, Sun G. A role of fluoride on free radical generation and oxidative stress in BV-2 microglia cells. Mediators Inflamm 2012;2012:102954. doi: 10.1155/2012/102954 Shuhua X Ziyou L Ling Y Fei W Sun G A role of fluoride on free radical generation and oxidative stress in BV-2 microglia cells Mediators Inflamm 20122012102954 10.1155/2012/102954342588922933830Open DOISearch in Google Scholar

78Varol E, Icli A, Aksoy F, Bas HA, Sutcu R, Ersoy IH, Varol S, Ozaydin M. Evaluation of total oxidative status and total antioxidant capacity in patients with endemic fluorosis. Toxicol Ind Health 2013;29:175–80. doi: 10.1177/0748233711428641 Varol E Icli A Aksoy F Bas HA Sutcu R Ersoy IH Varol S Ozaydin M Evaluation of total oxidative status and total antioxidant capacity in patients with endemic fluorosis Toxicol Ind Health 201329175 80 10.1177/074823371142864122155887Open DOISearch in Google Scholar

79Kirmit A, Yesilnacar M, Çalışır M, Bayhan İ, Çelik H. Oxidative stress, DNA damage and apoptosis levels in those who use borderline high level fluoride content drinking water. J Contemp Med 2020;10:45–50. doi: 10.16899/jcm.690968 Kirmit A Yesilnacar M Çalışır M Bayhan İ Çelik H Oxidative stress, DNA damage and apoptosis levels in those who use borderline high level fluoride content drinking water J Contemp Med 20201045 50 10.16899/jcm.690968Open DOISearch in Google Scholar

80Feng JF, Lu L, Dai CM, Wang D, Yang YH, Yang YW, Liu YS. Analysis of the diagnostic efficiency of serum oxidative stress parameters in patients with breast cancer at various clinical stages. Clin Biochem 2016;49(9):692–8. doi: 10.1016/j.clinbiochem.2016.02.005 Feng JF Lu L Dai CM Wang D Yang YH Yang YW Liu YS Analysis of the diagnostic efficiency of serum oxidative stress parameters in patients with breast cancer at various clinical stages Clin Biochem 2016499692 8 10.1016/j.clinbiochem.2016.02.00526899366Open DOISearch in Google Scholar

81Chouhan S, Kushwaha P, Kaul R, Flora SJS. Co-administration of selenium but not iron prevents fluoride toxicity in rats. Biomed Prev Nut 2013;3:113–20. doi: 10.1016/j.bionut.2012.08.007 Chouhan S Kushwaha P Kaul R Flora SJS Co-administration of selenium but not iron prevents fluoride toxicity in rats Biomed Prev Nut 20133113 20 10.1016/j.bionut.2012.08.007Open DOISearch in Google Scholar

82Basha PM, Madhusudhan N. Pre and post natal exposure of fluoride induced oxidative macromolecular alterations in developing central nervous system of rat and amelioration by antioxidants. Neurochem Res 2010;35:1017–28. doi: 10.1007/s11064-010-0150-2 Basha PM Madhusudhan N Pre and post natal exposure of fluoride induced oxidative macromolecular alterations in developing central nervous system of rat and amelioration by antioxidants Neurochem Res 2010351017 28 10.1007/s11064-010-0150-2Open DOISearch in Google Scholar

83Reddy KP, Sailaja G, Krishnaiah C. Protective effects of selenium on fluoride induced alterations in certain enzymes in brain of mice. J Environ Biol 2009;30(5 Suppl):859–64. PMID: 20143719 Reddy KP Sailaja G Krishnaiah C Protective effects of selenium on fluoride induced alterations in certain enzymes in brain of mice J Environ Biol 2009305 Suppl859 64 PMID: 20143719Search in Google Scholar

84Chen JJ, Cao JL, Luo YJ, Li JY. [Effects of nano-selenium on antioxidant capacity and histopathology of Cyprinus carpio liver under fluoride stress, in Chinese]. Ying Yong Sheng Tai Xue Bao 2013;24(10):2970–6. PMID: 24483095 Chen JJ Cao JL Luo YJ Li JY [Effects of nano-selenium on antioxidant capacity and histopathology of Cyprinus carpio liver under fluoride stress, in Chinese] Ying Yong Sheng Tai Xue Bao 201324102970 6 PMID: 24483095Search in Google Scholar

85Zia S, Islam F. Selenium altered the levels of lipids, lipid peroxidation, and sulfhydryl groups in straitum and thalamus of rat. Biol Trace Elem Res 2000;77:251–9. doi: 10.1385/bter:77:3:251 Zia S Islam F Selenium altered the levels of lipids, lipid peroxidation, and sulfhydryl groups in straitum and thalamus of rat Biol Trace Elem Res 200077251 9 10.1385/bter:77:3:251Open DOISearch in Google Scholar

86Islam F, Zia S, Sayeed I, Kaur P, Ahmad AS. Effect of selenium on lipids, lipid peroxidation, and sulfhydryl group in neuroendocrine centers of rats. Biol Trace Elem Res 2004;97:71–81. doi: 10.1385/ bter:97:1:71 Islam F Zia S Sayeed I Kaur P Ahmad AS Effect of selenium on lipids, lipid peroxidation, and sulfhydryl group in neuroendocrine centers of rats Biol Trace Elem Res 20049771 81 10.1385/bter:97:1:71Open DOISearch in Google Scholar

87Khandare AL, Validandi V, Boiroju N. Fluoride alters serum elemental (calcium, magnesium, copper, and zinc) homeostasis along with erythrocyte carbonic anhydrase activity in fluorosis endemic villages and restores on supply of safe drinking water in school-going children of Nalgonda District, India. Biol Trace Elem Res 2018;185:289–94. doi: 10.1007/s12011-018-1271-8 Khandare AL Validandi V Boiroju N Fluoride alters serum elemental (calcium, magnesium, copper, and zinc) homeostasis along with erythrocyte carbonic anhydrase activity in fluorosis endemic villages and restores on supply of safe drinking water in school-going children of Nalgonda District, India Biol Trace Elem Res 2018185289 94 10.1007/s12011-018-1271-8Open DOISearch in Google Scholar

88Çetin S, Yur F. Levels of trace elements in muscle and kidney tissues of sheep with fluorosis. Biol Trace Elem Res 2016;174:82–4. doi: 10.1007/s12011-016-0694-3 Çetin S Yur F Levels of trace elements in muscle and kidney tissues of sheep with fluorosis Biol Trace Elem Res 201617482 4 10.1007/s12011-016-0694-3Open DOISearch in Google Scholar

89Kanwar KC, Singh M. Zinc, copper and manganese levels in various tissues following fluoride administration. Experientia 1981;37:1328–9. doi: 10.1007/bf01948390 Kanwar KC Singh M Zinc, copper and manganese levels in various tissues following fluoride administration Experientia 1981371328 9 10.1007/bf01948390Open DOISearch in Google Scholar

90Kondaiah P, Yaduvanshi PS, Sharp PA, Pullakhandam R. Iron and zinc homeostasis and interactions: does enteric zinc excretion crosstalk with intestinal iron absorption? Nutrients 2019;11(8):1885. doi: 10.3390/nu11081885 Kondaiah P Yaduvanshi PS Sharp PA Pullakhandam R Iron and zinc homeostasis and interactions: does enteric zinc excretion crosstalk with intestinal iron absorption? Nutrients 20191181885 10.3390/nu11081885Open DOISearch in Google Scholar

91Chmielnicka J, Bem EM, Brzeźnicka EA, Kasperek M. The tissue disposition of zinc and copper following repeated administration of cadmium and selenium to rats. Environ Res 1985;37:419–24. doi: 10.1016/0013-9351(85)90123-9 Chmielnicka J Bem EM Brzeźnicka EA Kasperek M The tissue disposition of zinc and copper following repeated administration of cadmium and selenium to rats Environ Res 198537419 24 10.1016/0013-9351(85)90123-9Open DOISearch in Google Scholar

92Karunasinghe N, Ferguson LR. Could selenium be a double-edged sword? In: Collins JF, editor. Molecular, genetic, and nutritional aspects of major and trace Minerals. Boston: Academic Press; 2017. p. 475–86. Karunasinghe N Ferguson LR Could selenium be a double-edged sword? In Collins JF editor Molecular, genetic, and nutritional aspects of major and trace Minerals Boston Academic Press 2017 p 475–8610.1016/B978-0-12-802168-2.00039-7Search in Google Scholar

93Brozmanová J, Mániková D, Vlčková V, Chovanec M. Selenium: a double-edged sword for defense and offence in cancer. Arch Toxicol 2010;84:919–38. doi: 10.1007/s00204-010-0595-8 Brozmanová J Mániková D Vlčková V Chovanec M Selenium: a double-edged sword for defense and offence in cancer Arch Toxicol 201084919 38 10.1007/s00204-010-0595-8Open DOISearch in Google Scholar

94Daston GP, Rehnberg BF, Carver B, Kavlock RJ. Toxicity of sodium fluoride to the postnatally developing rat kidney. Environ Res 1985;37:461–74. doi: 10.1016/0013-9351(85)90128-8 Daston GP Rehnberg BF Carver B Kavlock RJ Toxicity of sodium fluoride to the postnatally developing rat kidney Environ Res 198537461 74 10.1016/0013-9351(85)90128-8Open DOISearch in Google Scholar