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Prenatal and perinatal phthalate exposure is associated with sex-dependent changes in hippocampal miR-15b-5p and miR-34a-5p expression and changes in testicular morphology in rat offspring

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Giuliani A, Zuccarini M, Cichelli A, Khan H, Reale M. Critical review on the presence of phthalates in food and evidence of their biological impact. Int J Environ Res Public Health 2020;17:5655. doi: 10.3390/ ijerph17165655 Giuliani A Zuccarini M Cichelli A Khan H Reale M Critical review on the presence of phthalates in food and evidence of their biological impact Int J Environ Res Public Health 2020175655 10.3390/ijerph17165655Open DOISearch in Google Scholar

Buckley JP, Palmieri RT, Matuszewski JM, Herring AH, Baird DD, Hartmann KE, Hoppin JA. Consumer product exposures associated with urinary phthalate levels in pregnant women. J Exp Sci Environ Epidemiol 2012;22:468-75. doi: 10.1038/jes.2012.33 Buckley JP Palmieri RT Matuszewski JM Herring AH Baird DD Hartmann KE Hoppin JA Consumer product exposures associated with urinary phthalate levels in pregnant women J Exp Sci Environ Epidemiol 201222468 75 10.1038/jes.2012.33Open DOISearch in Google Scholar

Cirillo T, Fasano E, Esposito F, Montuori P, Amodio Cocchieri R. Di(2-ethylhexyl) phthalate (DEHP) and di-n-butylphthalate (DBP) exposure through diet in hospital patients. Food Chem Toxicol 2013;51:434-8. doi: 10.1016/j.fct.2012.10.015 Cirillo T Fasano E Esposito F Montuori P Amodio Cocchieri R Di(2-ethylhexyl) phthalate (DEHP) and di-n-butylphthalate (DBP) exposure through diet in hospital patients Food Chem Toxicol 201351434 8 10.1016/j.fct.2012.10.015Open DOISearch in Google Scholar

Dutta S, Haggerty DK, Rappolee DA, Ruden DM. Phthalate exposure and long-term epigenomic consequences: a review. Front Genet 2020;11:405. doi: 10.3389/fgene.2020.00405 Dutta S Haggerty DK Rappolee DA Ruden DM Phthalate exposure and long-term epigenomic consequences: a review Front Genet 202011405 10.3389/fgene.2020.00405Open DOISearch in Google Scholar

Doyle TJ, Bowman JL, Windell VL, McLean DJ, Kim KH. Transgenerational effects of di-(2-ethylhexyl) phthalate on testicular germ cell associations and spermatogonial stem cells in mice. Biol Reprod 2013;88:112. doi: 10.1095/biolreprod.112.106104 Doyle TJ Bowman JL Windell VL McLean DJ Kim KH Transgenerational effects of di-(2-ethylhexyl) phthalate on testicular germ cell associations and spermatogonial stem cells in mice Biol Reprod 201388112 10.1095/biolreprod.112.106104Open DOISearch in Google Scholar

Martino-Andrade AJ, Liu F, Sathyanarayana S, Barrett ES, Redmon JB, Nguyen RH, Levine H, Swan SH; the TIDES Study Team. Timing of prenatal phthalate exposure in relation to genital endpoints in male newborns. Andrology 2016;4:585-93. doi: 10.1111/andr.12180 Martino-Andrade AJ Liu F Sathyanarayana S Barrett ES Redmon JB Nguyen RH Levine H Swan SH; the TIDES Study Team Timing of prenatal phthalate exposure in relation to genital endpoints in male newborns Andrology 20164585 93 10.1111/andr.12180Open DOISearch in Google Scholar

Lee HK, Kim TS, Kim CY, Kang IH, Kim MG, Jung KK, Kim HS, Han SY, Yoon HJ, Rhee GS. Evaluation of in vitro screening system for estrogenicity: comparison of stably transfected human estrogen receptor-alpha transcriptional activation (OECD TG455) assay and estrogen receptor (ER) binding assay. J Toxicol Sci 2012;37:431-7. doi: 10.2131/jts.37.431 Lee HK Kim TS Kim CY Kang IH Kim MG Jung KK Kim HS Han SY Yoon HJ Rhee GS Evaluation of in vitro screening system for estrogenicity: comparison of stably transfected human estrogen receptor-alpha transcriptional activation (OECD TG455) assay and estrogen receptor (ER) binding assay J Toxicol Sci 201237431 7 10.2131/jts.37.431Open DOISearch in Google Scholar

Huang PC, Li WF, Liao PC, Sun CW, Tsai EM, Wang SL. Risk for estrogen-dependent diseases in relation to phthalate exposure and polymorphisms of CYP17A1 and estrogen receptor genes. Environ Sci Pollut Res Int 2014;21:13964-73. doi: 10.1007/s11356-014-3260-6 Huang PC Li WF Liao PC Sun CW Tsai EM Wang SL Risk for estrogen-dependent diseases in relation to phthalate exposure and polymorphisms of CYP17A1 and estrogen receptor genes Environ Sci Pollut Res Int 20142113964 73 10.1007/s11356-014-3260-6Open DOISearch in Google Scholar

Fisher JS, Macpherson S, Marchetti N, Sharpe RM. Human “testicular dysgenesis syndrome”: a possible model using in utero exposure of the rat to dibutyl phthalate. Hum Reprod 2003;18:1383-94. doi: 10.1093/humrep/deg273 Fisher JS Macpherson S Marchetti N Sharpe RM Human “testicular dysgenesis syndrome”: a possible model using in utero exposure of the rat to dibutyl phthalate Hum Reprod 2003181383 94 10.1093/humrep/deg273Open DOISearch in Google Scholar

Mylchreest E, Sar M, Wallace DG, Foster PM. Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di-(n-butyl)-phthalate. Reprod Toxicol 2002;16:19-28. doi: 10.1016/s0890-6238(01)00201-5 Mylchreest E Sar M Wallace DG Foster PM Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di-(n-butyl)-phthalate Reprod Toxicol 20021619 28 10.1016/s0890-6238(01)00201-5Open DOISearch in Google Scholar

Parks LG, Ostby JS, Lambright CR, Abbott BD, Klinefelter GR, Barlow NJ, Gray Jr. LE. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol Sci 2000;58:339-49. doi: 10.1093/toxsci/58.2.339 Parks LG Ostby JS Lambright CR Abbott BD Klinefelter GR Barlow NJ Gray Jr LE The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol Sci 200058339 49 10.1093/toxsci/58.2.339Open DOISearch in Google Scholar

Davis BJ, Weaver R, Gaines LJ, Heindel JJ. Mono-(2-ethylhexyl)-phthalate suppresses estradiol production independent of FSH-cAMP stimulation in rat granulosa cells. Toxicol Appl Pharmacol 1994;128:224-8. doi: 10.1006/taap.1994.1201 Davis BJ Weaver R Gaines LJ Heindel JJ Mono-(2-ethylhexyl)-phthalate suppresses estradiol production independent of FSH-cAMP stimulation in rat granulosa cells Toxicol Appl Pharmacol 1994128224 8 10.1006/taap.1994.1201Open DOISearch in Google Scholar

Lovekamp TN, Davis BJ. Mono-(2-ethylhexyl)-phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells. Toxicol Appl Pharmacol 2001;172:217-24. doi: 10.1006/taap.2001.9156 Lovekamp TN Davis BJ Mono-(2-ethylhexyl)-phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells Toxicol Appl Pharmacol 2001172217 24 10.1006/taap.2001.9156Open DOISearch in Google Scholar

Lovekamp-Swan T, Davis BJ. Mechanisms of phthalate ester toxicity in the female reproductive system. Environ Health Perspect 2003;111:139-45. doi: 10.1289/ehp.5658 Lovekamp-Swan T Davis BJ Mechanisms of phthalate ester toxicity in the female reproductive system Environ Health Perspect 2003111139 45 10.1289/ehp.5658Open DOISearch in Google Scholar

Morová M, Senko T, Olexová L, Dzirbíková Z, Kršková L. A mixture of diethylhexyl, diisononyl and dibutyl phthalate decreased anogenital distance, postnatal testosterone levels, and changed social behavior in Wistar rats. Physiol Res 2020;69(Suppl 3):S489-98. doi: 10.33549/ physiolres.934599 Morová M Senko T Olexová L Dzirbíková Z Kršková L A mixture of diethylhexyl, diisononyl and dibutyl phthalate decreased anogenital distance, postnatal testosterone levels, and changed social behavior in Wistar rats Physiol Res 202069Suppl 3S489 98 10.33549/physiolres.934599Open DOISearch in Google Scholar

Moore NP. The oestrogenic potential of the phthalate esters. Reprod Toxicol 2000;14:183-92. doi: 10.1016/s0890-6238(00)00068-x Moore NP The oestrogenic potential of the phthalate esters Reprod Toxicol 200014183 92 10.1016/s0890-6238(00)00068-xOpen DOISearch in Google Scholar

Buñay J, Eduardo Larriba E, Ricardo D, Moreno RD, del Mazo J. Chronic low-dose exposure to a mixture of environmental endocrine disruptors induces microRNAs/isomiRs deregulation in mouse concomitant with intratesticular estradiol reduction. Sci Rep 2017;7:3373. doi: 10.1038/s41598-017-02752-7 Buñay J Eduardo Larriba E Ricardo D Moreno RD del Mazo J Chronic low-dose exposure to a mixture of environmental endocrine disruptors induces microRNAs/isomiRs deregulation in mouse concomitant with intratesticular estradiol reduction Sci Rep 201773373 10.1038/s41598-017-02752-7546981528611354Open DOISearch in Google Scholar

Štefánik P, Vanková V, Olexová L, Dzirbíková Z, Piešová M, Koprdová R, Mach M. The long-term sex-specific effect of sub chronic prenatal asphyxiaon miR-15b-5p and miR-124-3p levels in limbic system of rats and possible connection with regulation of GABA-ergic system. Act Nerv Super Rediviva 2021;63:36-48. Štefánik P Vanková V Olexová L Dzirbíková Z Piešová M Koprdová R Mach M The long-term sex-specific effect of sub chronic prenatal asphyxiaon miR-15b-5p and miR-124-3p levels in limbic system of rats and possible connection with regulation of GABA-ergic system Act Nerv Super Rediviva 20216336 48Search in Google Scholar

Hasakova K, Reis R, Vician M, Zeman M, Herichova I. Expression of miR-34a-5p is up-regulated in human colorectal cancer and correlates with survival and clock gene PER2 expression. PLoS One 2019;14(10):e0224396. doi: 10.1371/journal.pone.0224396 Hasakova K Reis R Vician M Zeman M Herichova I Expression of miR-34a-5p is up-regulated in human colorectal cancer and correlates with survival and clock gene PER2 expression PLoS One 20191410e0224396 10.1371/journal.pone.0224396681656431658284Open DOISearch in Google Scholar

Roselli CE, Klosterman SA. Sexual differentiation of aromatase activity in the rat brain: effects of perinatal steroid exposure. Endocrinology 1998;139:3193-201. doi: 10.1210/endo.139.7.6101 Roselli CE Klosterman SA Sexual differentiation of aromatase activity in the rat brain: effects of perinatal steroid exposure Endocrinology 19981393193 201 10.1210/endo.139.7.61019645693Open DOISearch in Google Scholar

Andrade AJM, Grande SW, Talsness ChE, Grote K, Chahoud I. A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): non-monotonic dose-response and low dose effects on rat brain aromatase activity. Toxicology 2006;227:185-92. doi: 10.1016/j.tox.2006.07.022 Andrade AJM Grande SW Talsness ChE Grote K Chahoud I A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): non-monotonic dose-response and low dose effects on rat brain aromatase activity Toxicology 2006227185 92 10.1016/j.tox.2006.07.02216949715Open DOISearch in Google Scholar

Kubo K, Arai O, Ogata R, Omura M, Hori T, Aou S. Exposure to bisphenol A during the fetal and suckling periods disrupts sexual differentiation of the locus coeruleus and of behavior in the rat. Neurosci Lett 2001;304:73-6. doi: 10.1016/s0304-3940(01)01760-8 Kubo K Arai O Ogata R Omura M Hori T Aou S Exposure to bisphenol A during the fetal and suckling periods disrupts sexual differentiation of the locus coeruleus and of behavior in the rat Neurosci Lett 200130473 6 10.1016/s0304-3940(01)01760-8Open DOISearch in Google Scholar

Patisaul HB, Polston EK. Influence of endocrine active compounds on the developing rodent brain. Brain Res Rev 2008;57:352-62. doi: 10.1016/j.brainresrev.2007.06.008 Patisaul HB Polston EK Influence of endocrine active compounds on the developing rodent brain Brain Res Rev 200857352 62 10.1016/j.brainresrev.2007.06.008Open DOISearch in Google Scholar

Prange-Kiel J, Rune GM. Direct and indirect effects of estrogen on rat hippocampus. Neuroscience 2006;138:765-72. doi: 10.1016/j. neuroscience.2005.05.061 Prange-Kiel J Rune GM Direct and indirect effects of estrogen on rat hippocampus Neuroscience 2006138765 72 10.1016/j.neuroscience.2005.05.061Open DOISearch in Google Scholar

Borrow AP, Handa RJ. Estrogen receptors modulation of anxiety-like behavior. Vitam Horm 2017;103:27-52. doi: 10.1016/bs.vh.2016.08.004 Borrow AP Handa RJ Estrogen receptors modulation of anxiety-like behavior Vitam Horm 201710327 52 10.1016/bs.vh.2016.08.004Open DOISearch in Google Scholar

Rubin RD, Watson PD, Duff MC, Cohen NJ. The role of the hippocampus in flexible cognition and social behavior. Front Hum Neurosci 2014;8:742. doi: 10.3389/fnhum.2014.00742 Rubin RD Watson PD Duff MC Cohen NJ The role of the hippocampus in flexible cognition and social behavior Front Hum Neurosci 20148742 10.3389/fnhum.2014.00742Open DOISearch in Google Scholar

Mlynarcıková A, Kolena J, Ficková M, Scsuková S. Alterations in steroid hormone production by porcine ovarian granulose cells caused by bisphenol A and bisphenol A dimethacrylate. Mol Cell Endocrinol 2005;244:57-62. doi: 10.1016/j.mce.2005.02.009 Mlynarcıková A Kolena J Ficková M Scsuková S Alterations in steroid hormone production by porcine ovarian granulose cells caused by bisphenol A and bisphenol A dimethacrylate Mol Cell Endocrinol 200524457 62 10.1016/j.mce.2005.02.009Open DOISearch in Google Scholar

Fujimoto T, Kubo K, Aou S. Prenatal exposure to bisphenol A impairs sexual differentiation of exploratory behavior and increases depression-like behavior in rats. Brain Res 2006;1068:49-55. doi: 10.1016/j.brainres.2005.11.028 Fujimoto T Kubo K Aou S Prenatal exposure to bisphenol A impairs sexual differentiation of exploratory behavior and increases depression-like behavior in rats Brain Res 2006106849 55 10.1016/j.brainres.2005.11.028Open DOISearch in Google Scholar

Kubo K, Arai O, Omura M, Watanabe R, Ogata R, Aou S. Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats. Neurosci Res 2003;45:345-56. doi: 10.1016/s0168-0102(02)00251-1 Kubo K Arai O Omura M Watanabe R Ogata R Aou S Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats Neurosci Res 200345345 56 10.1016/s0168-0102(02)00251-1Open DOISearch in Google Scholar

Gonçalves CR, Cunha RW, Barros DM, Martinez PE. Effects of prenatal and postnatal exposure to a low dose of bisphenol A on behavior and memory in rats. Environ Toxicol Pharmacol 2010;30:195-201. doi: 10.1016/j.etap.2010.06.003 Gonçalves CR Cunha RW Barros DM Martinez PE Effects of prenatal and postnatal exposure to a low dose of bisphenol A on behavior and memory in rats Environ Toxicol Pharmacol 201030195 201 10.1016/j.etap.2010.06.00321787652Open DOISearch in Google Scholar

Gioiosa L, Fissore E, Ghirardelli G, Parmigiani S, Palanza P. Developmental exposure to low-dose estrogenic endocrine disruptors alters sex differences in exploration and emotional responses in mice. Horm Behav 2007;52:307-16. doi: 10.1016/j.yhbeh.2007.05.006 Gioiosa L Fissore E Ghirardelli G Parmigiani S Palanza P Developmental exposure to low-dose estrogenic endocrine disruptors alters sex differences in exploration and emotional responses in mice Horm Behav 200752307 16 10.1016/j.yhbeh.2007.05.00617568585Open DOISearch in Google Scholar

Marcondes FK, Bianchi FJ, Tanno AP. Determination of the estrous cycle phases of rats: some helpful considerations. Braz J Biol 2002;62(4A):609-14. doi: 10.1590/s1519-69842002000400008 Marcondes FK Bianchi FJ Tanno AP Determination of the estrous cycle phases of rats: some helpful considerations Braz J Biol 2002624A609 14 10.1590/s1519-69842002000400008Open DOISearch in Google Scholar

Obernosterer G, Martinez GJ, Alenius M. Locked nucleic acid-based in situ detection of microRNAs in mouse tissue sections. Nat Protoc 2007;2:1508-14. doi: 10.1038/nprot.2007.153 Obernosterer G Martinez GJ Alenius M Locked nucleic acid-based in situ detection of microRNAs in mouse tissue sections Nat Protoc 200721508 14 10.1038/nprot.2007.153Open DOISearch in Google Scholar

Silahtaroglu AN, Nolting D, Dyrskjøt L, Berezikov E, Møller M, Tommerup N, Kauppinen S. Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification. Nat Protoc 2007;2:2520-8. doi: 10.1038/nprot.2007.313 Silahtaroglu AN Nolting D Dyrskjøt L Berezikov E Møller M Tommerup N Kauppinen S Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification Nat Protoc 200722520 8 10.1038/nprot.2007.313Open DOISearch in Google Scholar

Bankhead P, Loughrey MB, Fernández JA, Dombrowski Y, McArt DG, Dunne PD, McQuaid S, Gray RT, Murray LJ, Coleman HG, James JA, Salto-Tellez M, Hamilton PW. QuPath: Open source software for digital pathology image analysis. Sci Rep 2017;7:16878. doi: 10.1038/ s41598-017-17204-5 Bankhead P Loughrey MB Fernández JA Dombrowski Y McArt DG Dunne PD McQuaid S Gray RT Murray LJ Coleman HG James JA Salto-Tellez M Hamilton PW QuPath: Open source software for digital pathology image analysis Sci Rep 2017716878 10.1038/s41598-017-17204-5Open DOISearch in Google Scholar

Bhattacharya N, Dufour JM, Vo M-N, Okita J, Okita R, Kim KH. Differential effects of phthalates on the testis and the liver biology of reproduction 2005;72:745-54. doi: 10.1095/biolreprod.104.031583 Bhattacharya N Dufour JM Vo M-N Okita J Okita R Kim KH Differential effects of phthalates on the testis and the liver biology of reproduction 200572745 54 10.1095/biolreprod.104.031583Open DOISearch in Google Scholar

Li H, Kim KH. Effect of mono-(2-ethylhexyl) phthalate on fetal and neonatal rat testis organ cultures. Biol Reprod 2003;69:1964-72. doi: 10.1095/biolreprod.103.018895 Li H Kim KH Effect of mono-(2-ethylhexyl) phthalate on fetal and neonatal rat testis organ cultures Biol Reprod 2003691964 72 10.1095/biolreprod.103.018895Open DOISearch in Google Scholar

Li LH, Jester WF Jr, Orth JM. Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats. Toxicol Appl Pharmacol 1998;153:258-65. doi: 10.1006/taap.1998.8550 Li LH Jester WF Jr Orth JM Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats Toxicol Appl Pharmacol 1998153258 65 10.1006/taap.1998.8550Open DOISearch in Google Scholar

Li LH, Jester WF Jr, Laslett AL, Orth JM. A single dose of di-(2-ethylhexyl) phthalate in neonatal rats alters gonocytes, reduces Sertoli cell proliferation, and decreases cyclin D2 expression. Toxicol Appl Pharmacol 2000;166:222-9. doi: 10.1006/taap.2000.8972 Li LH Jester WF Jr Laslett AL Orth JM A single dose of di-(2-ethylhexyl) phthalate in neonatal rats alters gonocytes, reduces Sertoli cell proliferation, and decreases cyclin D2 expression Toxicol Appl Pharmacol 2000166222 9 10.1006/taap.2000.8972Open DOISearch in Google Scholar

Pak TR, Rao YS, Prins SA, Mott NN. An emerging role for microRNAs in sexually dimorphic neurobiological systems. Pflugers Arch 2013;465:655-67. doi: 10.1007/s00424-013-1227-y Pak TR Rao YS Prins SA Mott NN An emerging role for microRNAs in sexually dimorphic neurobiological systems Pflugers Arch 2013465655 67 10.1007/s00424-013-1227-yOpen DOISearch in Google Scholar

Masutomi N, Shibutani M, Takagi H, Uneyama Ch, Takahashi N, Hirose M. Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life. Toxicology 2003;192:149-70. doi: 10.1016/s0300-483x(03)00269-5 Masutomi N Shibutani M Takagi H Uneyama Ch Takahashi N Hirose M Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life Toxicology 2003192149 70 10.1016/s0300-483x(03)00269-5Open DOISearch in Google Scholar

Koturbash I, Zemp F, Kolb B, Kovalchuk O. Sex-specific radiation-induced microRNAome responses in the hippocampus, cerebellum and frontal cortex in a mouse model. Mutat Res 2011;722:114-8. doi: 10.1016/j.mrgentox.2010.05.007 Koturbash I Zemp F Kolb B Kovalchuk O Sex-specific radiation-induced microRNAome responses in the hippocampus, cerebellum and frontal cortex in a mouse model Mutat Res 2011722114 8 10.1016/j.mrgentox.2010.05.00720478395Open DOISearch in Google Scholar

Luo PX, Manning CE, Fass JN, Williams AV, Hao R, Campi KL, Trainor BC. Sex-specific effects of social defeat stress on miRNA expression in the anterior BNST. Behav Brain Res 2021;401:113084. doi: 10.1016/j.bbr.2020.113084 Luo PX Manning CE Fass JN Williams AV Hao R Campi KL Trainor BC Sex-specific effects of social defeat stress on miRNA expression in the anterior BNST Behav Brain Res 2021401113084 10.1016/j.bbr.2020.113084786428433358922Open DOISearch in Google Scholar

McKibben LA, Dwivedi Y. Early-life stress induces genome-wide sex-dependent miRNA expression and correlation across limbic brain areas in rats. Epigenomics 2021;13:1031-56. doi: 10.2217/epi-2021-0037 McKibben LA Dwivedi Y Early-life stress induces genome-wide sex-dependent miRNA expression and correlation across limbic brain areas in rats Epigenomics 2021131031 56 10.2217/epi-2021-0037824458334008410Open DOISearch in Google Scholar

Shih Y-L, Hsieh C-J, Lee T-Y, Liao P-H, Wu H-T, Liu C-Y. Sex differences between urinary phthalate metabolites and metabolic syndrome in adults: A cross-sectional Taiwan Biobank Study. Int J Environ Res Public Health 2022;19:10458. doi: 10.3390/ ijerph191610458 Shih Y-L Hsieh C-J Lee T-Y Liao P-H Wu H-T Liu C-Y Sex differences between urinary phthalate metabolites and metabolic syndrome in adults: A cross-sectional Taiwan Biobank Study Int J Environ Res Public Health 20221910458 10.3390/ijerph191610458940774736012094Open DOISearch in Google Scholar

Ghosh R, Haque M, Turner PC, Cruz-Cano R, Dallal CM. Racial and sex differences between urinary phthalates and metabolic syndrome among U.S. adults: NHANES 2005–2014. Int J Environ Res Public Health 2021;18:6870. doi: 10.3390/ijerph18136870 Ghosh R Haque M Turner PC Cruz-Cano R Dallal CM Racial and sex differences between urinary phthalates and metabolic syndrome among U.S adults: NHANES 2005–2014. Int J Environ Res Public Health 2021186870 10.3390/ijerph18136870829737834206929Open DOISearch in Google Scholar

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