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Characteristics of unintentional ingestion of oral non-steroidal anti-inflammatory drugs and analgesics in preschool children

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Figure 1

Data selection and extraction
Data selection and extraction

Profile of patients ingesting ibuprofen and paracetamol above maximum daily doses

Ibuprofen (MDD 30 mg/kg) Paracetamol (MDD 960 mg)
CPCC cases (N=121) CHZ cases (N=15) CPCC cases (N=35) CHZ cases (N=4)
Ingested dose in mg/kg, median (range) 60 (32–270)* 86 (34–256)* 86 (36–218)* 145 (86–203)*
Above toxic threshold of 200 mg/kg, N (%) 2 (2) 1 (7) 1 (3) 1 (25)
Symptomatic, N (%) 7 (6)* 7 (47)* 1 (3) 3 (75)
Doses in symptomatic patients, median (range) not investigated 72 (34–256) not investigated 145 (135–155)
Clinical effects, N (%)
vomiting not investigated 3 (20) not investigated 2 (50)
diarrhoea 1 (25)
abnormal laboratory findings 5 (33)** 2 (50)***

Patient demographics and circumstances of exposure (2009–2019)

CPCC cases (N=411) CHZ cases (N=55)
Age, median (IQR)* 2.5 (2.0–3.0) 2.9 (2.2–3.7)
Male sex, N (%*) 188(46) 32 (53)
Drug ingested, N (%)
ibuprofen 191(46) 26 (47)
paracetamol 79 (19) 14 (25)
ketoprofen 59(14) 9 (16)
diclofenac 44 (11) 5 (9)
acetylsalicylic acid 22 (5) 1 (2)
other** 16 (4)
Circumstances of exposure
unsupervised child ingested the drug left within reach 386(94) 54 (98)
dosing error made by parents/caregivers 25 (6) 1 (2)
eISSN:
1848-6312
Langues:
Anglais, Slovenian
Périodicité:
4 fois par an
Sujets de la revue:
Medicine, Basic Medical Science, other