<trans-abstract xml:lang="hr" xmlns="http://www.w3.org/1999/xhtml">

<p>Bolest uzrokovana koronavirusom (COVID-19) pandemija je koja ugrožava živote mnogih pojedinaca i organizacija u gotovo svim društvenim i gospodarskim sektorima diljem svijeta. Pri tome, međutim, najviše stradavaju ljudi medicinske struke, koji su na prvoj crti obrane izloženi bolesnicima i zaraznom materijalu. Kao česte žrtve virusa, oni su izloženi brojnim somatskim i psihosocijalnim problemima, no kako početkom 2020. godine infekcija SARS-CoV-2 nije još bila uvrštena među profesionalne bolesti, brojni zdravstveni radnici zatražili su od medicine rada priznavanje COVIDA-19 kao profesionalne bolesti. Kako bismo poduprli njihove opravdane zahtjeve, napravili smo kratak osvrt na zdravstveno stanje 100 zdravstvenih radnika zaraženih SARS-CoV-2, koji su od lipnja do kraja prosinca 2020. radili u pojedinim odjelima Kliničkoga bolničkog centra (KBC) u Rijeci. Opisali smo incidenciju i simptome COVID-19 u 11 kliničkih odjela KBC-a i naglasili važnu ulogu medicine rada u procjenjivanju akutnih i mogućih dugotrajnih posljedica COVIDA-19, koje se učestalo pojavljuju u zdravstvenih radnika.</p>
</trans-abstract>

Bolest uzrokovana koronavirusom (COVID-19) pandemija je koja ugrožava živote mnogih pojedinaca i organizacija u gotovo svim društvenim i gospodarskim sektorima diljem svijeta. Pri tome, međutim, najviše stradavaju ljudi medicinske struke, koji su na prvoj crti obrane izloženi bolesnicima i zaraznom materijalu. Kao česte žrtve virusa, oni su izloženi brojnim somatskim i psihosocijalnim problemima, no kako početkom 2020. godine infekcija SARS-CoV-2 nije još bila uvrštena među profesionalne bolesti, brojni zdravstveni radnici zatražili su od medicine rada priznavanje COVIDA-19 kao profesionalne bolesti. Kako bismo poduprli njihove opravdane zahtjeve, napravili smo kratak osvrt na zdravstveno stanje 100 zdravstvenih radnika zaraženih SARS-CoV-2, koji su od lipnja do kraja prosinca 2020. radili u pojedinim odjelima Kliničkoga bolničkog centra (KBC) u Rijeci. Opisali smo incidenciju i simptome COVID-19 u 11 kliničkih odjela KBC-a i naglasili važnu ulogu medicine rada u procjenjivanju akutnih i mogućih dugotrajnih posljedica COVIDA-19, koje se učestalo pojavljuju u zdravstvenih radnika.

<div xmlns="http://www.w3.org/1999/xhtml">
<p>Originating from Wuhan in China, the coronavirus disease-19 (COVID-19) reached global spread in just a few months. According to recent information issued by the World Health Organization (WHO), the number of affected persons surpassed 200 million in the world and 380 thousand in Croatia. The pandemic caused over 4.5 million deaths and resulted in long-lasting psychopathological and socioeconomic consequences owing to the lockdowns and epidemiological measures implemented to prevent the spread of infection. The disease created a heavy burden on health care and its workers (HCWs), who are in direct contact with infected patients and often affected by COVID-19 and associated somatic and mental health problems (<a ref-type="bibr" href="#j_aiht-2021-72-3520_ref_001">1</a>, <a ref-type="bibr" href="#j_aiht-2021-72-3520_ref_002">2</a>, <a ref-type="bibr" href="#j_aiht-2021-72-3520_ref_003">3</a>, <a ref-type="bibr" href="#j_aiht-2021-72-3520_ref_004">4</a>, <a ref-type="bibr" href="#j_aiht-2021-72-3520_ref_005">5</a>, <a ref-type="bibr" href="#j_aiht-2021-72-3520_ref_006">6</a>, <a ref-type="bibr" href="#j_aiht-2021-72-3520_ref_007">7</a>).</p>
<p>Even though they work on the first line of defence, however, COVID-19 had not been recognised as occupational disease in Croatia until the Croatian Medical Association’s Society of Occupational Health called attention to the issue. Until then, in 2020, many HCWs requested their occupational medicine (OM) physicians to help them prove the work-related character of their SARS-CoV-2 infection and obtain full salary compensation for sick leaves. These cases also provided important information about the symptoms and initial spread of COVID-19 among Croatian HCWs. In this context, Žaja et al. (<a ref-type="bibr" href="#j_aiht-2021-72-3520_ref_008">8</a>) collected data from HCWs in eight Croatian counties and reported that hospital nurses and laboratory technicians ran a higher risk of SARS-CoV-2 infection.</p>
<p>In an attempt to contribute to this knowledge, we made a short overview of the incidence of COVID-19 symptoms in 100 employees working at the Clinical Hospital Centre (CHC) Rijeka during the coronavirus outbreak in Croatia in 2020.</p>
<sec id="j_aiht-2021-72-3520_s_001"><div>Material and methods</div>
<sec id="j_aiht-2021-72-3520_s_001_s_001"><div>Participants, data collection, and analysis</div>
<p>The incidence of COVID-19 symptoms was analysed in 100 medical doctors, nurses, laboratory technicians, cleaners, and other professions employed in various departments of CHC Rijeka who requested their OM specialist to acknowledge their COVID-19 as occupational disease between 1 June 2020 and 31 December 2020. All of them had been on sick leave due to SARS-CoV-2 infection confirmed by PCR test results obtained at the University of Rijeka Faculty of Medicine.</p>
<p>Information about their workplace, age, gender, COVID-19 symptom severity, and duration of sick leave was collected through a questionnaire made for that purpose, in which they described the course of their illness and the symptoms associated with COVID-19, such as fever and respiratory, olfactory, gustatory, and other problems (<a ref-type="bibr" href="#j_aiht-2021-72-3520_ref_008">8</a>, <a ref-type="bibr" href="#j_aiht-2021-72-3520_ref_009">9</a>, <a ref-type="bibr" href="#j_aiht-2021-72-3520_ref_010">10</a>). The answers and PCR test results were received by e-mail or post after the participants completed their sick leave. They were then divided into 11 groups by workplace (surgery, emergency department, anaesthesiology, radiology, transfusion medicine, internal medicine, oncology, microbiology, dermatology, maintenance and administration, hospital pharmacy, ophthalmology, and clinic for infectious diseases) and classified by symptom severity as asymptomatic, mild, or moderate, depending on the number of self-reported COVID-19-related clinical symptoms. Symptoms were considered mild in participants who reported subfebrile body temperature (37.1–37.2 °C) and mild fatigue over a day or two without other symptoms. Moderate symptoms were considered those involving temperatures reaching 38–39 °C and prevalent fatigue, general weakness, dyspnoea, cough, stomach ache, diarrhoea, low back and other musculoskeletal pain, which lasted a week or so. Asymptomatic were those who reported no symptoms but were in self-isolation due to direct contact with infected patients and had a positive PCR test. None of the participants reported severe symptoms.</p>
<p>Participation was voluntary and the collected data were part of routine OM practice. The study was approved by the CHC Ethics Committee (Decision No. 01-47/3-3-21) and conducted in accordance with the principles of the Declaration of Helsinki.</p>
</sec>
<sec id="j_aiht-2021-72-3520_s_001_s_002"><div>Statistical analysis</div>
<p>The data are presented as number of cases, percentage, and incidence by department. COVID-19 incidence was calculated from the number of participant and the total number of employees in each department.</p>
<p>The statistical analyses were performed using Statistica version 12 (StatSoft Inc., Tulsa, OK, USA). Differences between parametric and nonparametric groups were assessed with Student’s <italic>t</italic>-test or Mann-Whitney <italic>U</italic> test, respectively. Parametric data are given as arithmetic means±standard deviation (SD). Statistical differences with p&lt;0.05 were considered significant.</p>
</sec></sec>
<sec id="j_aiht-2021-72-3520_s_002"><div>Results and discussion</div>
<p>Of the 100 HCWs with COVID-19 73 were women and 27 men. According to profession, 42 % were laboratory technicians, 34 % nurses, 18 % physicians, 4 % cleaners, and 2 % other professions. The average age of all infected employees was 43.2±6.5 (range 22–64) years, and most (63 %) developed mild symptoms (<a ref-type="table" href="#j_aiht-2021-72-3520_tab_001">Table 1</a>). Most participants worked in the surgery department (N=17), but the highest incidence of infection was in the microbiology department (25 %) (<a ref-type="table" href="#j_aiht-2021-72-3520_tab_001">Table 1</a>). This suggests that some departments entail a higher risk of exposure to contagious material and infected people (patients and colleagues) or take less precaution than other departments. We found no significant correlation between gender and COVID-19 incidence (data not shown).</p>
<table-wrap id="j_aiht-2021-72-3520_tab_001" position="float">
<label>Table 1</label>
<caption><p>Characteristics of COVID-19 in healthcare workers at the Clinical Hospital Centre Rijeka. Croatia (from 1 June to 31 December 2020)</p></caption>
<table frame="hsides" rules="rows">
<thead><tr><th align="left" rowspan="3">Departments</th>
<th align="center" rowspan="3">No. of cases</th>
<th align="center" rowspan="3">COVID-19 incidence (%)</th>
<th align="center" rowspan="3">Men (N)</th>
<th align="center" rowspan="3">Women (N)</th>
<th align="center" rowspan="3">Age (years) mean±SD</th>
<th align="center" rowspan="3">Sick leave (days) mean±SD</th>
<th align="center" colspan="3">COVID-19 symptom severity</th>
</tr>
<tr>
<th align="center">No symptoms</th>
<th align="center">Mild</th>
<th align="center">Moderate</th>
</tr>
<tr>
<th align="center" colspan="3">N (%) of cases</th>
</tr></thead>
<tbody>
<tr><td align="left">Surgery</td>
<td align="center">17</td>
<td align="center">5.9</td>
<td align="center">3</td>
<td align="center">14</td>
<td align="center">51.1±9.5</td>
<td align="center">18.1±10.2</td>
<td align="center">0</td>
<td align="center">(64.711 )</td>
<td align="center">6 (35.3)</td>
</tr>
<tr><td align="left">Emergency</td>
<td align="center">7</td>
<td align="center">5.7</td>
<td align="center">6</td>
<td align="center">1</td>
<td align="center">32.3±4.3**</td>
<td align="center">18.0±8.3</td>
<td align="center">3 (42.9)</td>
<td align="center">3 (42.9)</td>
<td align="center">1 (14.3)</td>
</tr>
<tr><td align="left">Anaesthesiology</td>
<td align="center">9</td>
<td align="center">4.1</td>
<td align="center">3</td>
<td align="center">6</td>
<td align="center">37.8±13.1</td>
<td align="center">13.0±9.8</td>
<td align="center">0</td>
<td align="center">8 (88.9)</td>
<td align="center">1 (11.1)</td>
</tr>
<tr><td align="left">Transfusion medicine</td>
<td align="center">6</td>
<td align="center">6.8</td>
<td align="center">0</td>
<td align="center">6</td>
<td align="center">34.2±11.3</td>
<td align="center">13.2±4.4</td>
<td align="center">2 (33.3)</td>
<td align="center">4 (66.7)</td>
<td align="center">0</td>
</tr>
<tr><td align="left">Internal medicine</td>
<td align="center">10</td>
<td align="center">13.0</td>
<td align="center">1</td>
<td align="center">9</td>
<td align="center">50.1±9.8</td>
<td align="center">14.0±4.4</td>
<td align="center">2 (20)</td>
<td align="center">6 (60.0)</td>
<td align="center">2 (20.0)</td>
</tr>
<tr><td align="left">Oncology</td>
<td align="center">11</td>
<td align="center">16.2</td>
<td align="center">0</td>
<td align="center">11</td>
<td align="center">45.7±14.7</td>
<td align="center">10.8±4.0</td>
<td align="center">0</td>
<td align="center">5 (45.5)</td>
<td align="center">6 (54.5)</td>
</tr>
<tr><td align="left">Microbiology</td>
<td align="center">8</td>
<td align="center">25.0</td>
<td align="center">0</td>
<td align="center">8</td>
<td align="center">37.6±13.8</td>
<td align="center">12.4±4.0</td>
<td align="center">0</td>
<td align="center">8 (100)</td>
<td align="center">0</td>
</tr>
<tr><td align="left">Radiology</td>
<td align="center">12</td>
<td align="center">5.8</td>
<td align="center">7</td>
<td align="center">5</td>
<td align="center">41.3±11.4</td>
<td align="center">13.1±8.6</td>
<td align="center">0</td>
<td align="center">7 (58.3)</td>
<td align="center">5 (41.7)</td>
</tr>
<tr><td align="left">Dermatology</td>
<td align="center">5</td>
<td align="center">11.4</td>
<td align="center">2</td>
<td align="center">3</td>
<td align="center">50.0±12.7</td>
<td align="center">10.2±1.1</td>
<td align="center">0</td>
<td align="center">5 (100)</td>
<td align="center">0</td>
</tr>
<tr><td align="left">Services</td>
<td align="center">9</td>
<td align="center">9.4</td>
<td align="center">5</td>
<td align="center">4</td>
<td align="center">46.3±12.2</td>
<td align="center">16.1±5.3</td>
<td align="center">0</td>
<td align="center">5 (55.6)</td>
<td align="center">4 (44.4)</td>
</tr>
<tr><td align="left">Other*</td>
<td align="center">6</td>
<td align="center">4.6</td>
<td align="center">0</td>
<td align="center">6</td>
<td align="center">48.8±9.5</td>
<td align="center">11.0±4.5</td>
<td align="center">3 (50)</td>
<td align="center">1 (16.7)</td>
<td align="center">2 (33.3)</td>
</tr>
<tr><td align="left"><bold>Total</bold></td>
<td align="center"><bold>100</bold></td>
<td align="center"><bold>9.8±6.3</bold></td>
<td align="center"><bold>27</bold></td>
<td align="center"><bold>73</bold></td>
<td align="center"><bold>43.2±6.5</bold></td>
<td align="center"><bold>13.6±2.6</bold></td>
<td align="center"><bold>10</bold></td>
<td align="center"><bold>63</bold></td>
<td align="center"><bold>27</bold></td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn-group>
<fn id="j_aiht-2021-72-3520_tfn_101"><p>* departments with &lt;3 COVID-19 cases (hospital pharmacy, ophthalmology, and clinic for infectious diseases); **p&lt;0.01</p></fn>
</fn-group>
</table-wrap-foot>
</table-wrap>
<p><a ref-type="table" href="#j_aiht-2021-72-3520_tab_002">Table 2</a> shows the distribution of symptoms typical of SARS-CoV-2 infection similarly to other reports (<a ref-type="bibr" href="#j_aiht-2021-72-3520_ref_008">8</a>, <a ref-type="bibr" href="#j_aiht-2021-72-3520_ref_009">9</a>, <a ref-type="bibr" href="#j_aiht-2021-72-3520_ref_010">10</a>). In fact, all of our results are in high agreement with the recently published data of Žaja et al. (<a ref-type="bibr" href="#j_aiht-2021-72-3520_ref_008">8</a>) for a similar population, who reported that most (78 %) COVID-19 patients were nurses or laboratory technicians working in hospitals and that they predominantly exhibited the mild form of the disease.</p>
<table-wrap id="j_aiht-2021-72-3520_tab_002" position="float">
<label>Table 2</label>
<caption><p>Distribution of COVID-19 symptoms by department</p></caption>
<table frame="hsides" rules="rows">
<thead><tr><th align="left" rowspan="2">Departments</th>
<th align="center" rowspan="2">No. of cases</th>
<th align="center" colspan="3">Temperature</th>
<th align="center" rowspan="2">Cough</th>
<th align="center" rowspan="2">Chills</th>
<th align="center" rowspan="2">No smell</th>
<th align="center" rowspan="2">No taste</th>
<th align="center" rowspan="2">Intestinal symptoms</th>
</tr>
<tr>
<th align="center">Low (37.1-37.2 °C)</th>
<th align="center">Moderate (38-39 °C)</th>
<th align="center">High (>39 °C)</th>
</tr></thead>
<tbody>
<tr><td align="left">Surgery</td>
<td align="center">17</td>
<td align="center">4</td>
<td align="center">11</td>
<td align="center">2</td>
<td align="center">4</td>
<td align="center">4</td>
<td align="center">9</td>
<td align="center">7</td>
<td align="center">1</td>
</tr>
<tr><td align="left">Emergency</td>
<td align="center">7</td>
<td align="center">6</td>
<td align="center">1</td>
<td align="center">0</td>
<td align="center">2</td>
<td align="center">1</td>
<td align="center">1</td>
<td align="center">0</td>
<td align="center">0</td>
</tr>
<tr><td align="left">Anaesthesiology</td>
<td align="center">9</td>
<td align="center">6</td>
<td align="center">3</td>
<td align="center">0</td>
<td align="center">1</td>
<td align="center">1</td>
<td align="center">4</td>
<td align="center">4</td>
<td align="center">0</td>
</tr>
<tr><td align="left">Transfusion medicine</td>
<td align="center">6</td>
<td align="center">3</td>
<td align="center">2</td>
<td align="center">1</td>
<td align="center">0</td>
<td align="center">0</td>
<td align="center">4</td>
<td align="center">2</td>
<td align="center">0</td>
</tr>
<tr><td align="left">Internal medicine</td>
<td align="center">10</td>
<td align="center">2</td>
<td align="center">4</td>
<td align="center">2</td>
<td align="center">1</td>
<td align="center">5</td>
<td align="center">5</td>
<td align="center">5</td>
<td align="center">0</td>
</tr>
<tr><td align="left">Oncology</td>
<td align="center">11</td>
<td align="center">4</td>
<td align="center">4</td>
<td align="center">3</td>
<td align="center">0</td>
<td align="center">3</td>
<td align="center">2</td>
<td align="center">2</td>
<td align="center">2</td>
</tr>
<tr><td align="left">Microbiology</td>
<td align="center">8</td>
<td align="center">6</td>
<td align="center">2</td>
<td align="center">0</td>
<td align="center">1</td>
<td align="center">2</td>
<td align="center">5</td>
<td align="center">5</td>
<td align="center">0</td>
</tr>
<tr><td align="left">Radiology</td>
<td align="center">12</td>
<td align="center">5</td>
<td align="center">5</td>
<td align="center">2</td>
<td align="center">1</td>
<td align="center">1</td>
<td align="center">1</td>
<td align="center">1</td>
<td align="center">0</td>
</tr>
<tr><td align="left">Dermatology</td>
<td align="center">5</td>
<td align="center">3</td>
<td align="center">2</td>
<td align="center">0</td>
<td align="center">1</td>
<td align="center">1</td>
<td align="center">1</td>
<td align="center">1</td>
<td align="center">0</td>
</tr>
<tr><td align="left">Services</td>
<td align="center">9</td>
<td align="center">3</td>
<td align="center">4</td>
<td align="center">2</td>
<td align="center">1</td>
<td align="center">5</td>
<td align="center">2</td>
<td align="center">1</td>
<td align="center">2</td>
</tr>
<tr><td align="left">Other*</td>
<td align="center">6</td>
<td align="center">1</td>
<td align="center">1</td>
<td align="center">1</td>
<td align="center">1</td>
<td align="center">2</td>
<td align="center">2</td>
<td align="center">1</td>
<td align="center">0</td>
</tr>
<tr><td align="left"><bold>Total</bold></td>
<td align="center"><bold>100</bold></td>
<td align="center"><bold>43</bold></td>
<td align="center"><bold>39</bold></td>
<td align="center"><bold>13</bold></td>
<td align="center"><bold>13</bold></td>
<td align="center"><bold>25</bold></td>
<td align="center"><bold>36</bold></td>
<td align="center"><bold>29</bold></td>
<td align="center"><bold>5</bold></td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn-group>
<fn id="j_aiht-2021-72-3520_tfn_102"><p>* departments with &lt;3 COVID-19 cases (hospital pharmacy, ophthalmology, and clinic for infectious diseases)</p></fn>
</fn-group>
</table-wrap-foot>
</table-wrap>
<p>Our data also show that the sick leaves of our participants lasted 13.6±2.6 days (<a ref-type="table" href="#j_aiht-2021-72-3520_tab_001">Table 1</a>). As soon as the SARS-CoV-2 infection in HCWs was classified as occupational disease, the Croatian Health Insurance Fund allocated full benefits, including fully paid sick leave and psychological support to the affected HCWs.</p>
<p>Hopefully this short overview has succeeded in highlighting the difficult position in which HCWs in CHC Rijeka found themselves during the initial spread of COVID and in underlining the importance of OM physicians in helping to resolve post COVID-19 issues.</p>
</sec>
</div>

Covid-19 as occupational disease in healthcare workers: a brief review of cases in the Clinical Hospital Centre Rijeka, Croatia

Archives of Industrial Hygiene and Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

COVID-19 kao profesionalna bolest zdravstvenih radnika ‒ kratki pregled slučajeva u Kliničkom bolničkom centru Rijeka

Bolest uzrokovana koronavirusom (COVID-19) pandemija je koja ugrožava živote mnogih pojedinaca i organizacija u gotovo svim društvenim i gospodarskim sektorima...

Covid-19 as occupational disease in healthcare workers: a brief review of cases in the Clinical Hospital Centre Rijeka, Croatia

Article Category: Original article (short communication)

Publié en ligne: 28 sept. 2021

Pages: 240 - 243

Reçu: 01 janv. 2021

Accepté: 01 sept. 2021

DOI: https://doi.org/10.2478/aiht-2021-72-3520

© 2021 Hrvoje Lalić, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.